[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636608":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":26,"responsibleParty":46,"collaborators":49,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":26,"maxAge":26,"enrollmentInfo":62,"targetDuration":26,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":76,"whyStopped":26,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":26},{"fullName":5,"class":6},"Singapore Eye Research Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Multidisciplinary protocolized intervention (MPI)","ACTIVE_COMPARATOR","Consists of medical consultation, to optimize the treatment regimen, and combinations of appropriate referrals to either (1) a nurse-directed patient education program (NE), (2) a low vision optometrist (OP), (3) an occupational therapy services (OT) and\u002For (4) a medical social worker (SW).\n\nCATs specific to AMD and DME will be used to measure QoL by collecting scores in various patient-informed domains. Lower scores at baseline, or a significant reduction in scores on follow-up visits in the various domains, will inform potential areas to address and tailor our MPI accordingly.",[13],"Behavioral: multidisciplinary protocolized intervention (MPI)",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard care","PLACEBO_COMPARATOR","In the standard care arm, the treating clinician will be masked from the CAT scores and will use his\u002Fher own discretion when recommending the treatment regimen or when making any appropriate nurse or allied health referrals, independent of the CAT scores.",[19],"Behavioral: Routine medical care & monitoring",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","multidisciplinary protocolized intervention (MPI)","Our novel proposed approach to improve adherence to IVT is personalized patient-centred care comprising a multidisciplinary protocolized intervention (MPI), which consists of medical consultation, to optimize the treatment regimen, and combinations of appropriate referrals to either (1) a nurse-directed patient education program (NE), (2) a low vision optometrist (OP), (3) an occupational therapy services (OT) and\u002For (4) a medical social worker (SW).",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Routine medical care & monitoring","The CAT scores will be recorded by the clinical research coordinator at baseline and follow-up visits for comparison to the MPI arm.",[15],[32],{"name":33,"affiliation":34,"role":35},"Anna CS Tan, PhD","Singapore Eye Research Institute (SERI)","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Anna Tan CS Clinical Associate Professor, PhD","CONTACT","+65-63227424","anna.tan.c.s@singhealth.com.sg",{"name":43,"role":39,"phone":44,"phoneExt":26,"email":45},"NEO WT Clinical Research Coordinator, Diploma","+65-90584081","neo.wee.teck@seri.com.sg",{"type":35,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Tan Cheng Sim Anna","Associate Professor",[50],{"name":51,"class":52},"Singapore National Eye Centre","OTHER_GOV","100636608","effectiveness-of-multidisciplinary-protocolised-interventions-on-ivt-non-adherence-rates-100636608",false,"NCT07567898","Effectiveness of Multidisciplinary Protocolised Interventions on IVT Non-adherence Rates","The Effectiveness of Multidisciplinary Protocolised Interventions to Reduce Non-adherencE Rates (ADHERE) in Patients With Chronic Macula Diseases Receiving Intravitreal Injections: A Randomised Controlled Trial","ADHERE","Inclusion Criteria:\n\n* Patients with chronic macula disease including those diagnosed with nAMD and DME, who require IVT.\n* This would include treatment naive patients (no IVT in either eye the last 6 months) and previously treated patients who have had IVT in either eye in the last 6 months and require further IVT treatment at the baseline study visit in either eye.\n* Able to provide informed consent and must consent to undergoing the MPI intervention.\n* Speak English or Mandarin.\n* Must be a Singapore resident.\n\nExclusion Criteria:\n\n* Patients who are unwilling or unable to perform CAT testing.\n* Unable to provide informed consent.\n* Significant eye pathology such as cornea problems, glaucoma, or other retinal diseases that may substantially affect vision.\n* Do not speak English or Mandarin fluently.\n* Cognitive impairment (as assessed using 6CIT).\n* Obvious observable physical or hearing disabilities that prevents them from completing the CAT questionnaire and undergoing MPI effectively.","ALL",{"count":63,"type":64},200,"ESTIMATED","INTERVENTIONAL",[67],"NA","The purpose of this research study is to test whether a personalised care approach improves adherence compared to standard care. Many patients with macular diseases like age-related macular degeneration and diabetic macular edema need regular eye injections to protect their vision. However, some do not adhere to their treatment appointments, risking further vision loss.\n\nYou were selected as a possible participant in this research study because you have been diagnosed with neovascular age-related macular degeneration (nAMD) or diabetic macula edema (DME) requiring intravitreal injection treatment (IVT).\n\nThis research study targets to recruit 200 participants from the Singapore National Eye Centre.\n\nThis study comprises two cohort groups: Cohort 1(Suboptimal CAT scores\u002F Randomized Control trial) and Cohort 2 (Optimal CAT scores\u002FObservation).\n\nIf you agree to take part in this study, the research coordinator will obtain your written consent before proceeding with the study procedures. You will be required to complete CAT assessment (via remote or administered in clinic) and assigned to cohort 1 or cohort 2 based on CAT scores result. If you are assigned to cohort 1, you will be randomly allocated to either the personalized multi-disciplinary protocolized intervention (MPI) or standard care group. Randomization means assigning you to one of two groups by chance, like tossing a coin or rolling a dice.\n\n* MPI group: You will complete a specialized computerized adaptive testing (CAT) quality of life questionnaire. Based on the domain specific scores, you will receive a medical consultation and a referral to nurse educators, optometrists, occupational therapists, or social workers.\n* Standard care group: If you are allocated to this group, you will receive standard care, where doctors make treatment decisions without using the CAT results.\n\nIf you are assigned to cohort 2, you will be placed under prospective observation and undergo routine clinical care.",[70,71,72],"Diabetic Macular Edema","Neovascular (Wet) Age-Related Macular Degeneration","Intravitreal Injection",[74,75],"ADHERE, Macular diseases, Intravitreal injections.","neovascular age-related macular","NOT_YET_RECRUITING","2026-04-28",{"date":79,"type":80},"2026-05-05","ACTUAL",{"date":82,"type":64},"2026-04",{"date":84,"type":64},"2028-09",{"name":5,"class":6}]