[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644271":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":63,"centralContacts":75,"locations":84,"responsibleParty":104,"collaborators":106,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":79,"eligibilityCriteria":114,"healthyVolunteers":110,"sex":115,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":79,"studyType":121,"phases":122,"briefSummary":124,"conditions":125,"keywords":127,"overallStatus":87,"whyStopped":79,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":140},{"fullName":5,"class":6},"Khyber Medical University Peshawar","OTHER",[8,15,21,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Gut-Targeted Supplements Group","EXPERIMENTAL","Participants will receive prebiotics (inulin 6 g\u002Fday) and probiotics (Acidophilus Bifidus 2 × 10\\^11 CFU\u002Fday orally) for 12 weeks.",[13,14],"Dietary Supplement: Inulin","Dietary Supplement: Probiotic",{"label":16,"type":10,"description":17,"interventionNames":18},"Neuroplasticity-Targeted Supplements Group","Participants will receive omega-3 fatty acids containing EPA 650 mg and DHA 540 mg daily, plus vitamin B1 (thiamine 10 mg\u002Fday orally) for 12 weeks.",[19,20],"Dietary Supplement: Omega-3 Fatty Acids","Dietary Supplement: Thiamine",{"label":22,"type":10,"description":23,"interventionNames":24},"Combined Supplements Group","Participants will receive prebiotics (inulin 6 g\u002Fday), probiotics (Acidophilus Bifidus 2 × 10\\^11 CFU\u002Fday), omega-3 fatty acids containing EPA 650 mg and DHA 540 mg daily, and vitamin B1 (thiamine 10 mg\u002Fday orally) for 12 weeks.",[13,14,19,20],{"label":26,"type":27,"description":28,"interventionNames":29},"Placebo Group","PLACEBO_COMPARATOR","Participants will receive matching placebo supplements orally for 12 weeks.",[30],"Other: Placebo",[32,39,45,51,57],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"DIETARY_SUPPLEMENT","Inulin","Participants will receive inulin powder 6 grams orally once daily for 12 weeks as a prebiotic supplement intended to support beneficial gut microbiota.",[22,9],[38],"Fructan prebiotic",{"type":33,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Probiotic","Participants will receive a probiotic supplement containing Acidophilus Bifidus 2 × 10\\^11 CFU orally once daily for 12 weeks.",[22,9],[44],"Acidophilus Bifidus",{"type":33,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"Omega-3 Fatty Acids","Participants will receive omega-3 fatty acid supplementation containing EPA 650 mg and DHA 540 mg orally once daily for 12 weeks.",[22,16],[50],"Fish Oil, EPA, DHA",{"type":33,"name":52,"description":53,"armGroupLabels":54,"otherNames":55},"Thiamine","Participants will receive thiamine (vitamin B1) 10 mg orally once daily for 12 weeks.",[22,16],[56],"Vitamin B1",{"type":6,"name":58,"description":59,"armGroupLabels":60,"otherNames":61},"Placebo","Participants will receive matching placebo supplementation orally once daily for 12 weeks.",[26],[62],"Matching placebo",[64,68,70,72],{"name":65,"affiliation":66,"role":67},"Dr Dur E Shawar, PhD*","Khyber Medical University Peshawar, Pakistan","PRINCIPAL_INVESTIGATOR",{"name":69,"affiliation":66,"role":67},"Prof Dr Inayat Shah, PhD",{"name":71,"affiliation":66,"role":67},"Prof Dr Omer Malik, PhD",{"name":73,"affiliation":74,"role":67},"Dr Madiha Khattak, PhD","Khyber Medical College",[76,81],{"name":65,"role":77,"phone":78,"phoneExt":79,"email":80},"CONTACT","03348405894",null,"shehwar88@gmail.com",{"name":69,"role":77,"phone":82,"phoneExt":79,"email":83},"03321431414","inayat.shah@kmu.edu.pk",[85],{"facility":86,"status":87,"city":88,"state":89,"zip":90,"country":91,"countryCode":92,"cosmosGeoPoint":93,"geoPoint":98,"contacts":99},"Khyber Teaching Hospital","RECRUITING","Peshawar","KPK","25000","Pakistan","PK",{"type":94,"coordinates":95},"Point",[96,97],71.57849,34.008,{"lat":97,"lon":96},[100,102],{"name":101,"role":77,"phone":79,"phoneExt":79,"email":79},"Dr Dur e",{"name":103,"role":77,"phone":79,"phoneExt":79,"email":79},"Dr Inayat Khan",{"type":105,"investigatorFullName":79,"investigatorTitle":79,"investigatorAffiliation":79,"oldNameTitle":79,"oldOrganization":79},"SPONSOR",[107],{"name":86,"class":6},"100644271","effectiveness-of-neuroplasticity-targeted-supplements-on-neuroinflammatory-markers-adhd-symptom-severity-and-clinical-scores-in-children-100644271",false,"NCT07665658","Effectiveness of Neuroplasticity-Targeted Supplements on Neuroinflammatory Markers, ADHD Symptom Severity, and Clinical Scores in Children","Effectiveness of Neuroplasticity-Targeted Supplements on Neuroinflammatory Markers, ADHD Symptom Severity, and Clinical Scores in Children: A Randomized Controlled Trial","Inclusion Criteria:\n\n* DSM-5 confirmed ADHD diagnosis\n* Age 6-12 years\n* Medication-free or on stable stimulant medication (≥1 month)\n\nExclusion Criteria:\n\n* Antibiotic use in last 4 weeks\n* Gastrointestinal disorders\n* Neurological comorbidities (e.g., epilepsy)\n* Severe food allergies","ALL","6 Years","12 Years",{"count":119,"type":120},68,"ESTIMATED","INTERVENTIONAL",[123],"NA","This randomized controlled trial will evaluate the effectiveness of neuroplasticity-targeted supplements on neuroinflammatory markers and ADHD symptoms in children aged 6 to 12 years diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). Participants will be randomly assigned to one of four groups: gut-targeted supplements (prebiotics and probiotics), brain-targeted supplements (omega-3 fatty acids and vitamin B1), combined supplementation, or placebo. The intervention period will last 12 weeks. Primary outcomes include changes in ADHD symptom severity and clinical scores using validated rating scales. Secondary outcomes include changes in biomarkers of neuroinflammation and neuroplasticity, including IL-6, TNF-alpha, BDNF, short-chain fatty acids, and Claudin-5.",[126],"Attention Deficit Hyperactivity Disorder",[126,128,129,130],"Randomized Controlled Trial","Neuroinflammation","Neuroplasticity","2026-06-22",{"date":133,"type":134},"2026-06-24","ACTUAL",{"date":136,"type":134},"2026-03-01",{"date":138,"type":120},"2026-12-25",{"name":5,"class":6},1]