[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553280":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":18,"locations":18,"responsibleParty":25,"collaborators":18,"id":27,"slug":28,"hasResults":29,"nctId":30,"briefTitle":31,"officialTitle":32,"acronym":33,"eligibilityCriteria":34,"healthyVolunteers":29,"sex":35,"minAge":36,"maxAge":18,"enrollmentInfo":37,"targetDuration":18,"studyType":40,"phases":41,"briefSummary":43,"conditions":44,"keywords":47,"overallStatus":49,"whyStopped":18,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":18},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group with periodontal treatment strategy","EXPERIMENTAL","Group with periodontal treatment strategy, in addition to routine care and secondary prevention of ischemic stroke",[13],"Procedure: periodontal treatment strategy",{"label":15,"type":16,"description":17,"interventionNames":18},"Group without periodontal treatment","NO_INTERVENTION","Group without periodontal treatment, with routine care and secondary prevention of ischemic stroke",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","periodontal treatment strategy","Periodontal treatment sessions (Experimental Group only) (1 to 3 months) after randomization",[9],{"type":26,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100553280","effectiveness-of-periodontitis-treatment-on-the-metabolic-activity-of-symptomatic-carotid-atherosclerotic-plaque-responsible-for-ischemic-stroke-100553280",false,"NCT06484036","Effectiveness of Periodontitis Treatment on the Metabolic Activity of Symptomatic Carotid Atherosclerotic Plaque Responsible for Ischemic Stroke","Effectiveness of Periodontitis Treatment on the Metabolic Activity of Symptomatic Carotid Atherosclerotic Plaque Responsible for Ischemic Stroke: a Multicenter Randomized Controlled Trial: a Multicenter Randomized Controlled Trial","PerioStroke","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Minor ischemic stroke of the anterior circulation (NIHSS ≤ 5) of atherothrombotic origin according to the TOAST scale \\\u003C30 days\n* Atheroma plaque of the ipsilateral carotid bulb \\>30% not eligible for intervention (endarterectomy or angioplasty-stenting)\n* Severe periodontitis (stage 3 or 4)\n* Signed informed consent\n* Affiliation to a social security scheme\n\nExclusion Criteria:\n\n* \\\u003C 6 teeth\n* Without independent oral hygiene\n* Contraindications to PET scan\n* Known allergy to fluoro-deoxyglucose and its excipient\n* Immunosuppressive treatment\n* Uncontrolled diabetes\n* High risk of infective endocarditis\n* Organ transplant pending\n* Progressive infectious diseases\n* Active smoking not stopped\n* Patient deprived of liberty by judicial or administrative decision\n* Patient under legal protection (guardianship, curatorship)\n* Participation in another interventional research involving humans or being in the exclusion period following previous research involving humans\n* Pregnant or breastfeeding woman Patient under AME (state medical aid)","ALL","18 Years",{"count":38,"type":39},157,"ESTIMATED","INTERVENTIONAL",[42],"NA","Cardiovascular disease is the world's leading cause of death. Atherothrombosis is a common cause of ischemic stroke.\n\nA strong epidemiological link has been established between periodontitis and the risk of stroke. It shares common risk factors with atherothrombosis, and its severe form is associated with low-grade systemic inflammation and daily low-intensity bacteremia. Atherothrombosis is a frequent cause of ischemic stroke.\n\nPeriodontal bacteria have been found within atheromatous plaques, correlated with a greater risk of rupture.\n\nThus, periodontitis could be a modifiable risk factor for atherothrombosis and future vascular events: its early diagnosis and treatment could have a major impact on cardiovascular prevention.\n\nHypothesis: In patients with periodontitis who have had an ischemic stroke, periodontal treatment may reduce atherosclerotic plaque activity.",[45,46],"Severe Periodontitis","Ischemic Stroke",[48,45,46],"PET scan","NOT_YET_RECRUITING","2024-06-28",{"date":52,"type":53},"2024-07-03","ACTUAL",{"date":55,"type":39},"2024-09-01",{"date":57,"type":39},"2028-09-01",{"name":5,"class":6}]