[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641352":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":66,"collaborators":26,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":92,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Postgraduate Institute of Dental Sciences Rohtak","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group","EXPERIMENTAL","Intervention Group participants will receive subgingival instrumentation using an ultrasonic scaler (NSK Variose 2 Ultrasonic Scaler) and hand instruments (Sickle scalers and Curettes, GDC) followed by oral hygiene instructions (OHI).",[13,14],"Procedure: Subgingival Instrumentation","Other: Oral Hygiene Instructions",{"label":16,"type":17,"description":18,"interventionNames":19},"Comparator Group","ACTIVE_COMPARATOR","Control group participants will receive basic oral hygiene instructions",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Subgingival Instrumentation","Participants will receive subgingival instrumentation using an ultrasonic scaler (NSK Variose 2 Ultrasonic Scaler) and hand instruments (Sickle scalers and Curettes, GDC) followed by oral hygiene instructions (OHI).",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Oral Hygiene Instructions","Participants will receive basic oral hygiene instructions",[16,9],[32],{"name":33,"affiliation":34,"role":35},"Vipul Yadav, MDS","Professor, Department of Public Health Dentistry, Post Graduate Institute of Dental Sciences Rohtak","STUDY_DIRECTOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Gurleen Kaur, MDS","CONTACT","+91 9354031553","drgurleenphd@gmail.com",{"name":33,"role":39,"phone":43,"phoneExt":26,"email":44},"+91 8826363961","vipulyadavv.97@gmail.com",[46],{"facility":47,"status":26,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Post Graduate Institute of Dental Sciences , Rohtak","Rohtak","Haryana","124001","India","IN",{"type":54,"coordinates":55},"Point",[56,57],76.58917,28.89447,{"lat":57,"lon":56},[60,62,64],{"name":38,"role":39,"phone":61,"phoneExt":26,"email":41},"9354031553",{"name":33,"role":39,"phone":63,"phoneExt":26,"email":44},"8826363961",{"name":38,"role":65,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"type":67,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100641352","effectiveness-of-subgingival-instrumentation-on-delaying-end-stage-renal-disease-among-chronic-kidney-disease-patients-100641352",false,"NCT07635797","Effectiveness of Subgingival Instrumentation on Delaying End-stage Renal Disease Among Chronic Kidney Disease Patients","Effectiveness of Subgingival Instrumentation on Delaying End-stage Renal Disease Among Chronic Kidney Disease Patients: A Non-Randomized Clinical Study","Inclusion Criteria:\n\n* Patients aged 40-70 years.\n* Type 2 diabetes mellitus with chronic kidney disease and currently on oral hypoglycaemic agents.\n* Diagnosed with Stage IV or V (eGFR between 15-20 mL\u002Fmin\u002F1.73m²).\n* Not undergoing dialysis.\n* Presence of ≥20 natural teeth.\n* Diagnosed with moderate (Stage II) (as per 2017 World Workshop classification) (Interdental CAL at site of greatest loss \\>2mm but \\\u003C5 mm in ≥ 2 non-adjacent teeth).\n* Willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Patients already undergoing haemodialysis or renal transplantation.\n* Patients on insulin therapy or taking SGLT2 inhibitors and GLP-1 receptor agonists.\n* HbA1c level \\>8 %.\n* Any Periodontal therapy within past 6 months.\n* Immunocompromised patients.\n* Any history of tobacco use.\n* Pregnant or lactating women.","ALL","40 Years","70 Years",{"count":79,"type":80},40,"ESTIMATED","INTERVENTIONAL",[83],"NA","Chronic kidney disease (CKD) and periodontitis share a bidirectional inflammatory relationship, with cytokines such as IL-6, TNF-α, and hsCRP driving progression in both conditions. Non-surgical periodontal therapy (NSPT) has shown reductions in systemic inflammatory markers with emerging evidence of improved renal function, yet robust randomized controlled trials targeting pre-dialysis stage IV-V diabetic CKD patients remain lacking. In the Indian context, where diabetes-related CKD is rapidly rising and access to dialysis is limited, there is a clear lacuna in literature regarding the effectiveness of NSPT in delaying progression to end-stage renal disease. Hence, the present non-randomized clinical study is undertaken to address this gap.",[86,87,88],"Chronic Kidney Disease","Periodontitis","End Stage Renal Disease (ESRD)",[86,23,87,90,91],"End Stage Renal Disease","Dialysis","NOT_YET_RECRUITING","2026-06-16",{"date":95,"type":96},"2026-06-18","ACTUAL",{"date":98,"type":80},"2026-07",{"date":100,"type":80},"2027-12",{"name":5,"class":6},1]