[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605885":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":35,"locations":45,"responsibleParty":56,"collaborators":60,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":34,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":34,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":92,"whyStopped":34,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"National University Health System, Singapore","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A (1-Ico)","ACTIVE_COMPARATOR","Group A (One icodextrin exchange followed by two icodextrin exchanges)",[13,14],"Drug: One icodextrin exchange","Drug: Two icodextrin exchanges",{"label":16,"type":17,"description":18,"interventionNames":19},"Group B (2-Ico)","EXPERIMENTAL","Group B (Two icodextrin exchanges followed by one icodextrin exchange)",[13,14],[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","One icodextrin exchange","One icodextrin fill volume of 550ml\u002Fm2 body surface area which is optimal for most paediatric patients is recommended. The minimum dwell time for an icodextrin exchange will be 7 hours, and range between 7-10 hours.",[9,16],[27],"1-Ico",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Two icodextrin exchanges","In two icodextin exchanges, the dwell times can vary but must be a minimum of 7 hours.",[9,16],[33],"2-Ico",null,[36,41],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},"Sharon Teo, Consultant","CONTACT","+65 91678482","sharon_teo@nuhs.edu.sg",{"name":42,"role":38,"phone":43,"phoneExt":34,"email":44},"Mya Than, Master of Public Health","+6581387599","paeumt@nus.edu.sg",[46],{"facility":47,"status":34,"city":48,"state":34,"zip":34,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":34},"National University Hospital","Singapore","SG",{"type":51,"coordinates":52},"Point",[53,54],103.85007,1.28967,{"lat":54,"lon":53},{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","Sharon Teo","Consultant",[61,63,65],{"name":62,"class":6},"The UCL Great Ormond Street Institute of Child Health",{"name":64,"class":6},"Children's Hospital of Fudan University",{"name":66,"class":67},"Philippine Children's Medical Center","OTHER_GOV","100605885","effectiveness-of-two-icodextrin-exchanges-on-fluid-status-and-blood-pressure-control-compared-to-a-single-icodextrin-exchange-100605885",false,"NCT07168343","Effectiveness of Two Icodextrin Exchanges on Fluid Status and Blood Pressure Control Compared to a Single Icodextrin Exchange","The Effect of Two Icodextrin Exchanges on Fluid Status and Blood Pressure Control in Children on Chronic Peritoneal Dialysis","Inclusion Criteria:\n\n1. Children 5-18 years of age\n2. Receiving CAPD or CCPD for at least the preceding 4 weeks, and not likely to change from CAPD to CCPD during the study period\n3. 24-hour mean arterial pressure (MAP; measured by ambulatory blood pressure monitoring (ABPM) above the 95th percentile for age, sex, and height\n4. 24-hour urine output less than 200ml\u002Fday\n\nExclusion Criteria:\n\n1. Children under 5 years of age (as younger children are more prone to hyponatremia)\n2. Children with systolic BP \\\u003C 50th centile for age, sex, and height in the preceding 4 weeks)\n3. Children who are polyuric or those prone to hypotension (defined as \\> 2 episodes of systolic BP \\\u003C 5th centile in the 4 weeks preceding the study)\n4. Known allergy to starch\n5. Pregnant women\n6. Patients with maltose or isomaltose intolerance, glycogen storage disease, pre-existing severe lactic acidosis, uncorrectable mechanical defects that prevent effective PD or increase the risk of infection and documented loss of peritoneal function or extensive adhesions that compromise peritoneal function","ALL","5 Years","18 Years",{"count":79,"type":80},10,"ESTIMATED","INTERVENTIONAL",[83],"NA","Fluid overload and hypertension are prevalent in children undergoing chronic peritoneal dialysis (PD), especially in low- and middle-income countries (LMICs). These complications often lead to increased hospitalizations, higher medication use, and, in some cases, conversion to hemodialysis. Icodextrin is used to enhance ultrafiltration (UF) and reduce glucose exposure, but its effectiveness in children with a single long dwell has been inconsistent. Preliminary observations suggest that shorter, twice-daily icodextrin exchanges may improve UF and blood pressure (BP) control. However, no randomized trial has evaluated this approach in pediatric patients.",[86],"Children on Chronic Peritoneal Dialysis",[88,89,90,91],"Children","CAPD","CCPD","Icodextrin","NOT_YET_RECRUITING","2026-01-18",{"date":95,"type":96},"2026-01-21","ACTUAL",{"date":98,"type":80},"2026-02-28",{"date":100,"type":80},"2028-06-30",{"name":5,"class":6},1]