[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594667":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":18,"responsibleParty":30,"collaborators":18,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":18,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":42,"enrollmentInfo":43,"targetDuration":18,"studyType":46,"phases":47,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":57,"whyStopped":18,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":18},{"fullName":5,"class":6},"University of Seville","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Strength training","EXPERIMENTAL","Participants will perform a cognitively demanding exercise while simultaneously performing strength training. With each repetition, the software will display in numbers the average concentric power output performed by the participants. Based on the benefits of performing a cognitively demanding physical exercise, participants will be asked to repeat out loud the value of the average concentric power output of the previous repetition while performing the next one.",[13],"Other: Interval strength training",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","These patients only receive the usual treatment for their pathology.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"Interval strength training","The intervention involves interval strength training with biofeedback and real-time decision-making for Alzheimer\\'s patients. Participants will complete 24 sessions, each including a circuit of strength exercises using rotational inertial devices (flywheels). Exercises, such as leg press, seated row, and bicep curl, will be randomly ordered, with load progression based on performance stability. Each session includes five sets per exercise, performed in a circuit, with a total of 15 sets over approximately 45 minutes. Real-time monitoring using a rotary encoder will track effort, and participants will continue each set until a 30% drop in average power is detected, ensuring consistent relative effort across sets.\n\nAdditionally, participants will engage in cognitively demanding tasks during training by verbally reporting the average power of the previous repetition while performing the next one. This dual-task approach aims to maximize both physical and cognitive engagement.",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Alejandro Muñoz López","CONTACT","+34955421006","amunoz26@us.es",{"type":31,"investigatorFullName":26,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Assistant Professor","100594667","effects-of-a-cognitive-engaging-strength-training-program-on-health-physical-condition-and-quality-of-life-in-people-with-alzheimers-disease-100594667",false,"NCT07022431","Effects of a Cognitive-Engaging Strength Training Program on Health, Physical Condition, and Quality of Life in People With Alzheimer's Disease","Effects of a Strength Training Program With High Cognitive Engagement on Health, Physical Condition, and Quality of Life in People With Alzheimer's Disease","Inclusion Criteria:\n\n* Meet the criteria for early AD dementia (GDS 4) (according to the DSM-IV-TR and NINCDS-ADRDA criteria)\n* Have a score between 15 and 20 on the Mini-Mental State Examination scale (Trivedi, 2017), with criteria for moderate cognitive impairment.\n* Maintain a stable pharmacological regimen for at least 30 days prior.\n* Give consent to be evaluated using the cognitive screening tests described in this report.\n* Be available to attend in person weekly at the headquarters where the training will take place in Seville capital.\n\nExclusion Criteria:\n\n* Presence of heart disease or other diseases that lead to a contraindication in the practice of physical activity.\n* Presence of psychiatric illnesses.\n* Having some musculoskeletal pathology or alteration that does not allow the performance of the proposed exercises or proposed conditional evaluations.\n* Having a resting heart rate less than 50 or greater than 100 beats per minute.\n* Having a diagnosed intellectual disability.","ALL","65 Years","75 Years",{"count":44,"type":45},34,"ESTIMATED","INTERVENTIONAL",[48],"NA","The primary objective of this project is to examine the impact of a strength training program with high cognitive demands on cognitive function, motor skills, physical fitness, and quality of life in individuals with Alzheimer's disease and mild cognitive impairment. This randomized controlled trial will involve participants for a total of five months. Initial two weeks will be for cognitive, physical fitness, quality of life, and specific biochemical profile evaluations, along with familiarization sessions with the exercise routine. The experimental group will then undertake a supervised strength training program twice a week for 16 weeks. The final two weeks will involve re-evaluations of all initial assessments. Participants will be randomized into a control group and an intervention group with a minimum of 17 individuals each. Stratification criteria for randomization include physical activity level, number of Alzheimer's disease-related risk factors, extent of brain damage based on MRI biomarkers, and clinical dementia rating scores.",[51],"Alzheimer Disease",[53,54,55,56],"Alzheimer's Disease","Cognitive Function","High Cognitive Demand Exercises","Strength Training","NOT_YET_RECRUITING","2025-06-06",{"date":60,"type":61},"2025-06-15","ACTUAL",{"date":63,"type":45},"2025-10",{"date":65,"type":45},"2026-07",{"name":5,"class":6}]