[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638932":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":26,"eligibilityCriteria":44,"healthyVolunteers":41,"sex":45,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":26,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":63,"whyStopped":26,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":26},{"fullName":5,"class":6},"Sierra Varona SL","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"rTMS Group","EXPERIMENTAL","Participants assigned to this arm received low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with task-specific physical therapy. rTMS was applied over the primary motor cortex (M1) of the unaffected hemisphere at a frequency of 1 Hz and an intensity of 90% of the individual resting motor threshold. Each session delivered 1,200 pulses over 20 minutes. Immediately after each rTMS session, participants underwent a standardized physical therapy session focused on lower-limb strengthening and balance training. This combined intervention was designed to modulate interhemispheric inhibition and facilitate motor recovery in individuals with chronic post-stroke hemiplegia.",[13,14],"Device: rTMS","Other: physical therapy",{"label":16,"type":17,"description":18,"interventionNames":19},"physical therapy Group","ACTIVE_COMPARATOR","Participants assigned to this arm received a standardized physical therapy program focused on motor recovery, balance training, and functional mobility in chronic post-stroke hemiplegia. The intervention included task-specific exercises targeting the affected lower limb, muscle strengthening, postural control, and balance activities adapted to individual functional capacity. Therapy sessions were designed according to neurorehabilitation principles and progressed based on patient performance and tolerance. This arm served as a reference intervention to describe functional changes associated with conventional physical therapy in the chronic phase of stroke recovery.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","rTMS","Repetitive transcranial magnetic stimulation (rTMS) was delivered using low-frequency stimulation applied over the primary motor cortex. Stimulation parameters were individually adjusted based on the resting motor threshold and kept constant across sessions. Coil positioning and stimulation conditions were standardized to ensure reproducibility. Safety screening was conducted prior to stimulation sessions, and adverse events were monitored throughout the intervention period in accordance with established safety guidelines.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"physical therapy","The physical therapy intervention consisted of a structured, task-oriented rehabilitation approach targeting motor control, balance, and functional mobility. Exercises were selected to promote activation of the affected limb, postural control, and functional movement patterns. The intervention followed standardized neurorehabilitation principles, with progressive adaptation of tasks based on individual performance and tolerance.",[16,9],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"ALBERTO SANCHEZ SIERRA, PhD","CONTACT","608801238","alberto.sanchez@uclm.es",{"type":38,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100638932","effects-of-a-combined-repetitive-transcranial-magnetic-stimulation-and-physical-therapy-protocol-on-motor-function-balance-and-quality-of-life-in-chronic-post-stroke-hemiplegia-a-case-series-100638932",false,"NCT07597746","\"Effects of a Combined Repetitive Transcranial Magnetic Stimulation and Physical Therapy Protocol on Motor Function, Balance, and Quality of Life in Chronic Post-Stroke Hemiplegia: A Case Series\"","Inclusion Criteria:\n\n* Diagnosis of first-ever unilateral ischemic or hemorrhagic stroke confirmed by neuroimaging (CT or MRI)\n* Chronic post-stroke hemiplegia (≥ 6 months since stroke onset)\n* Moderate to severe motor impairment of the affected lower limb (FMA-LE score between 10 and 28 points)\n* Age between 18 and 75 years\n* Medically stable and able to participate in a rehabilitation program\n* Ability to understand study procedures and provide written informed consent\n* No contraindications to repetitive transcranial magnetic stimulation (rTMS), according to current safety guidelines.\n\nExclusion Criteria:\n\n* History of epilepsy or seizures\n* Presence of pacemakers, cochlear implants, intracranial metallic implants, or other contraindications to rTMS\n* Severe cognitive impairment or communication deficits preventing participation\n* Progressive neurological disorders or unstable medical conditions\n* Participation in other experimental neurorehabilitation interventions during the study period\n* Any condition judged by investigators to compromise safety or data valid","ALL","18 Years","75 Years",{"count":49,"type":50},20,"ESTIMATED","INTERVENTIONAL",[53],"NA","Chronic post-stroke hemiplegia frequently results in persistent motor deficits, impaired balance, and reduced quality of life. Conventional physical therapy is fundamental for functional recovery; however, motor improvement often plateaus during the chronic phase. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique that has shown potential to enhance motor recovery by modulating cortical excitability and promoting neuroplasticity.\n\nThis case series aims to investigate the effects of a combined protocol of repetitive transcranial magnetic stimulation and conventional physical therapy on motor function, balance, and quality of life in individuals with chronic post-stroke hemiplegia. Participants will undergo rTMS applied to the motor cortex in conjunction with a structured physical therapy program. Clinical outcomes will be assessed before and after the intervention to explore feasibility, safety, and potential functional benefits of the combined approach.",[56,57],"Chronic Stroke","Balance",[59,60,61,62,28],"repetitive transcraneal magnetic stimulation","chronic stroke","motor recovery","balance","NOT_YET_RECRUITING","2026-05-13",{"date":66,"type":67},"2026-05-19","ACTUAL",{"date":69,"type":50},"2026-06-05",{"date":71,"type":50},"2026-08-30",{"name":5,"class":6}]