[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599535":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":18,"locations":24,"responsibleParty":44,"collaborators":18,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":18,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":18,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":18,"overallStatus":27,"whyStopped":18,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Guangdong Provincial Hospital of Traditional Chinese Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sleep Deprivation","EXPERIMENTAL","24 hours of sleep deprivation",[13],"Behavioral: Sleep Deprivation",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","24 hours of a normal work-rest schedule",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"BEHAVIORAL","Sleep deprivation for up to 24 hours with no naps or other sleep periods",[9],[25],{"facility":26,"status":27,"city":28,"state":29,"zip":18,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Guangdong Provincial Hospital of Chinese Medicine","RECRUITING","Guangzhou","Guangdong","China","CN",{"type":33,"coordinates":34},"Point",[35,36],113.25,23.11667,{"lat":36,"lon":35},[39],{"name":40,"role":41,"phone":42,"phoneExt":18,"email":43},"yuhui qiu","CONTACT","020-81887233","doctorqiuqiu@gzucm.edu.cn",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Yuhui Qiu","Principal Investigator","100599535","effects-of-acute-sleep-deprivation-on-individuals-with-different-apoe-genotypes-100599535",false,"NCT07085754","Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes","Inclusion Criteria:\n\n* Age 18-40 years, gender not limited\n* Healthy (with no clinically significant abnormal findings in the physical examination report or self-reporting as healthy) and not on medications\n* Cognitively normal (Mini-Mental State Examination (MMSE) score \\> 28)\n* Sleep duration of 7-9 hours per night, good sleep quality (Pittsburgh Sleep Quality Index (PSQI) ≤ 5 points)\n* Written informed consent, voluntarily participate in this study, and be able to cooperate with the physician to complete the clinical study\n\nExclusion Criteria:\n\n* Presence of day-night sleep reversal\n* Shift work within the past 6 months\n* Travel across time zones or experience of jet lag within the past three weeks\n* Current smoking or nicotine use; alcohol consumption exceeding five standard units per week (one standard alcohol unit is defined as 10 mL \\[or 8 g\\] of pure alcohol)\n* Consumption of strong tea, coffee, or caffeine-containing foods and beverages within one week before study participation\n* Family history of early-onset dementia\n* Self-Rating Depression Scale (SDS) score ≥ 53, Self-Rating Anxiety Scale (SAS) score ≥ 50\n* Female participants who are currently pregnant or breastfeeding\n* Individuals who need to drive or operate vehicles or machinery during the study period",true,"ALL","18 Years","40 Years",{"count":59,"type":60},60,"ESTIMATED","INTERVENTIONAL",[63],"NA","This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep deprivation in AD risk.",[66,9],"Sleep","2025-12-18",{"date":69,"type":70},"2025-12-24","ACTUAL",{"date":72,"type":70},"2025-08-08",{"date":74,"type":60},"2026-12-31",{"name":46,"class":6},1]