[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521754":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":34,"locations":35,"responsibleParty":64,"collaborators":34,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":34,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":34,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":38,"whyStopped":34,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Sao Paulo","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Antimicrobial Photodynamic therapy adjunct to scaling and root planing","EXPERIMENTAL","Treatment of scaling and root planing followed by antimicrobial photodynamic therapy with methylene blue (100 micrograms\u002Fml) and red laser",[13],"Procedure: antimicrobial photodynamic therapy (aPDT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","ACTIVE_COMPARATOR","Treatment of scaling and root planing.",[19],"Procedure: Control",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","antimicrobial photodynamic therapy (aPDT)","Scaling and root planing followed by antimicrobial photodynamic therapy",[9],[27,28],"Photodynamic therapy","Photochemotherapy",{"type":22,"name":15,"description":30,"armGroupLabels":31,"otherNames":32},"Treatment of scaling and root planing",[15],[33],"scaling and root planing",null,[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Bauru School of Dentistry","RECRUITING","Bauru","São Paulo","17012-901","Brazil","BR",{"type":45,"coordinates":46},"Point",[47,48],-49.06056,-22.31472,{"lat":48,"lon":47},[51,56,60,62],{"name":52,"role":53,"phone":54,"phoneExt":34,"email":55},"Carla Damante, PhD","CONTACT","+55 14 32266064","cdamante@usp.br",{"name":57,"role":53,"phone":58,"phoneExt":34,"email":59},"Andreia Pavani, PhD","+55 14 32358366","a-deia@hotmail.com",{"name":52,"role":61,"phone":34,"phoneExt":34,"email":34},"PRINCIPAL_INVESTIGATOR",{"name":57,"role":63,"phone":34,"phoneExt":34,"email":34},"SUB_INVESTIGATOR",{"type":61,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Carla Andreotti Damante","Associate professor","100521754","effects-of-adjunct-antimicrobial-photodynamic-therapy-in-periodontal-treatment-of-patients-with-obesity-100521754",false,"NCT06073704","Effects of Adjunct Antimicrobial Photodynamic Therapy in Periodontal Treatment of Patients With Obesity","Effects of Antimicrobial Photodynamic Therapy in Non-surgical Periodontal Treatment of Patients With Obesity","Inclusion Criteria:\n\n* Obesity (grade II and III classified according to Body Mass Index)\n* Periodontitis stage II to IV\n* Presence of at least 20 teeth excluding 3rd molars.\n\nExclusion Criteria:\n\n* Smokers\n* Alcohol or drugs consumption\n* Kidney disorders\n* Pregnancy or lactation\n* Use of antibiotics at the last 30 days\n* Use of drugs that alter periodontal structures as phenytoin or ciclosporin\n* Periodontal treatment at the last 6 months","ALL","18 Years","70 Years",{"count":78,"type":79},24,"ESTIMATED","INTERVENTIONAL",[82],"NA","The goal of this clinical trial is to compare the effects of adjuvant antimicrobial photodynamic therapy (aPDT) as an adjuvant of scaling and root planing with scaling and root planing alone for periodontal treatment in patients with periodontal disease and obesity. The main question it aims to answer are: Does adjuvant aPDT improves periodontal health? Are there differences in the proteomic profile of gingival fluid after both treatments? Participants will receive scaling and root planing complemented or not by aPDT. Results will be collected after 1, 3, and 6 months. Researchers will compare adjuvant aPDT treatment to regular treatment to see if it promotes reduction in inflammation and improvement in periodontal health.",[85,86],"Periodontitis","Obesity",[88,89],"periodontitis","obesity","2026-04-27",{"date":92,"type":93},"2026-05-04","ACTUAL",{"date":95,"type":93},"2023-10-09",{"date":97,"type":79},"2026-12-30",{"name":5,"class":6},1]