[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613938":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":33,"responsibleParty":52,"collaborators":10,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University of Ljubljana","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy group",null,"Healthy participants without a history of ankle sprain or self-reported ankle instability. Participants in this group will complete the same experimental protocol as Chronic ankle instability group, which includes treadmill walking at two speeds (0.4 m\u002Fs and 1.0 m\u002Fs) with and without mechanical perturbations, performed before and after an ankle evertor fatigue protocol. For this group, the fatigued limb will be assigned based on the laterality of ankle sprains observed in the CAI group.",[13],"Other: Muscle fatigue",{"label":15,"type":10,"description":16,"interventionNames":17},"Chronic ankle instability group","Participants with chronic ankle instability, defined by a history of recurrent ankle sprains and self-reported instability. Participants in this group will complete the same experimental protocol as Healthy group, which includes treadmill walking at two speeds (0.4 m\u002Fs and 1.0 m\u002Fs) with and without mechanical perturbations, performed before and after an ankle evertor fatigue protocol. For this group, the fatigued limb will be the symptomatic side.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Muscle fatigue","The fatigue protocol will consist of repeated concentric-eccentric ankle eversion contractions against elastic resistance at a pace of one repetition per second, guided by a metronome, and performed in a seated position. Fatigue will be defined as a clear inability to perform the full range of eversion, i.e. the range of motion falling below 50% of the initial value despite evident effort by the participant.",[15,9],[24,29],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Alan Kacin, PhD, PT, Prof","CONTACT","+38613001119","alan.kacin@zf.uni-lj.si",{"name":30,"role":26,"phone":31,"phoneExt":10,"email":32},"Tjaž Brezovar","+38640777919","tjaz.brezovar@zf.uni-lj.si",[34],{"facility":35,"status":36,"city":37,"state":10,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"University Rehabilitation Institute Republic of Slovenia - URI Soča","RECRUITING","Ljubljana","1000","Slovenia","SI",{"type":42,"coordinates":43},"Point",[44,45],14.50513,46.05108,{"lat":45,"lon":44},[48],{"name":49,"role":26,"phone":50,"phoneExt":10,"email":51},"Urška Puh, PhD, PT, Assoc. Prof","+38640577131","urska.puh@ir-rs.si",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Alan Kacin","Head of Laboratory","100613938","effects-of-ankle-evertor-fatigue-on-perturbed-gait-100613938",false,"NCT07273097","Effects of Ankle Evertor Fatigue on Perturbed Gait","Effects of Ankle Evertor Fatigue on Gait Perturbation Responses in Individuals With and Without Chronic Ankle Instability","Inclusion criteria for the healthy control group (no CAI):\n\n* Age between 18 and 45 years,\n* No history of injuries or surgical procedures to the lower limbs,\n* No peripheral or central neurological impairments.\n\nInclusion criteria for the chronic ankle instability (CAI) group:\n\n* Age between 18 and 45 years,\n* No history of major surgical procedures on the lower limbs\n* No peripheral or central neurological impairments,\n* Diagnosed chronic ankle instability:\n\n  * First ankle sprain occurred at least one year prior to testing,\n  * At least three months since the most recent ankle sprain,\n  * Subjective feeling of ankle instability - CAIT (Cumberland Ankle Instability Tool) score \\\u003C 24.\n\nExclusion criteria for the CAI group:\n\n* Other pathologies of the ankle joint.\n* Acute pain",true,"ALL","18 Years","45 Years",{"count":68,"type":69},40,"ESTIMATED","OBSERVATIONAL","This study will investigate the effects of ankle evertor muscle fatigue on gait stability during treadmill walking with mechanical perturbations. Participants will walk at two speeds (0.4 m\u002Fs and 1.0 m\u002Fs) while random medial and lateral perturbations (\\\u003C10% body weight) are applied to the pelvis. Surface EMG from ankle muscles and center of pressure (COP)-based gait parameters (e.g., step length, step width, single support duration, COP trajectory) will be analyzed before and immediately after an isotonic fatigue protocol of the ankle evertors.",[73],"Chronic Ankle Instability, CAI",[75,76,77],"perturbed walking","fatigue","treadmill","2026-04-28",{"date":80,"type":81},"2026-04-29","ACTUAL",{"date":83,"type":81},"2025-05-05",{"date":85,"type":69},"2026-05-06",{"name":5,"class":6},1]