[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634608":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":28,"locations":11,"responsibleParty":34,"collaborators":38,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":11,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":11,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":11,"overallStatus":62,"whyStopped":11,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":11},{"fullName":5,"class":6},"University of Central Lancashire","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Berberine tablets 500mg 2 x p\u002Fd","EXPERIMENTAL",null,[13],"Dietary Supplement: Berberine",{"label":15,"type":16,"description":11,"interventionNames":17},"Placebo","PLACEBO_COMPARATOR",[18],"Other: Placebo",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DIETARY_SUPPLEMENT","Berberine","Berberine supplement 500 mg 2 x per day",[9],{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":11},"Placebo control 2 x blinded placebo tablet per day",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"Jonathan K Sinclair, PhD, DSc","CONTACT","01772892796","jksinclair@lancashire.ac.uk",{"type":35,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Jonathan Sinclair","Professor",[39],{"name":40,"class":41},"DoNotAge.org","INDUSTRY","100634608","effects-of-berberine-on-cardiometabolic-outcomes-100634608",false,"NCT07541898","Effects of Berberine on Cardiometabolic Outcomes","Effects of Berberine Supplementation on Cardiometabolic Parameters","Inclusion Criteria:\n\n* Healthy\n* Between 18 \\& 65 years\n* Non-smoker\n* BMI \\\u003C 30\n* Able to give informed consent\n\nExclusion Criteria:\n\n* Pregnancy\n* Diabetes or any other metabolic\u002F uncontrolled hypertensive conditions\n* Food allergies to berberine\n* Habitual consumption of berberine\n* Not regularly taking medication or antioxidant supplements",true,"ALL","18 Years","65 Years",{"count":54,"type":55},40,"ESTIMATED","INTERVENTIONAL",[58],"NA","Cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount. Dietary interventions to improve cardiometabolic health are highly sought after as they possess less risk than pharmacological drugs. It has been postulated that Berberine may be beneficial in improving cardiometabolic outcomes. However, to date, no research has explored this using a placebo randomized intervention.",[61],"Cardiometabolic Syndrome","NOT_YET_RECRUITING","2026-04-14",{"date":65,"type":66},"2026-04-21","ACTUAL",{"date":68,"type":55},"2026-07-01",{"date":70,"type":55},"2029-01-01",{"name":5,"class":6}]