[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100233990":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":41,"locations":50,"responsibleParty":71,"collaborators":74,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":31,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":31,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":52,"whyStopped":31,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Spaulding Rehabilitation Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"AIH\u002FWalk","ACTIVE_COMPARATOR","Subjects with chronic, motor-incomplete SCI receive acute intermittent hypoxia (AIH) with walking practice, then AIH with strength practice and compare their efficacy on enhancing strength and\u002For walking performance.",[13,14],"Other: AIH","Other: Walk",{"label":16,"type":10,"description":17,"interventionNames":18},"AIH\u002FStrength","Subjects with chronic, motor-incomplete SCI receive AIH with strength practice, then AIH with walking practice and compare their efficacy on enhancing strength and\u002For walking performance.",[13,19],"Other: Strength",[21,27,32],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"AIH","Participants will breathe intermittent low oxygen via air generators. The generators will fill reservoir bags attached to a non-rebreathing face mask. Oxygen concentration will be continuously monitored to ensure delivery of fraction of inspired oxygen (FiO2) = 0.10±0.02 (hypoxia). Participants will receive treatment on 5 consecutive days.",[16,9],[26],"Acute Intermittent Hypoxia",{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Walk","30 minutes of walking practice consisting of 5 repetitions of 6-minute walks",[9],null,{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Strength","30 minutes of isometric ankle plantar flexion torque practice broken into 3 sets of 10 repetitions",[16],[37],{"name":38,"affiliation":39,"role":40},"Randy D Trumbower, PT, PhD","Harvard Medical School (HMS and HSDM)","PRINCIPAL_INVESTIGATOR",[42,46],{"name":38,"role":43,"phone":44,"phoneExt":31,"email":45},"CONTACT","617-952-6951","randy.trumbower@mgh.harvard.edu",{"name":47,"role":43,"phone":48,"phoneExt":31,"email":49},"Stella Barth, BA","617-952-6822","sbarth@partners.org",[51],{"facility":5,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"RECRUITING","Cambridge","Massachusetts","02138","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-71.10561,42.3751,{"lat":62,"lon":61},[65,67],{"name":38,"role":43,"phone":66,"phoneExt":31,"email":45},"(617) 952-6951",{"name":68,"role":43,"phone":69,"phoneExt":31,"email":70},"Melissa DeChellis, BA","(617) 952-6953","mpierre19@partners.org",{"type":40,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Randy Trumbower, PT, PhD","Assistant Professor",[75,77],{"name":76,"class":6},"Foundation Wings For Life",{"name":78,"class":79},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH","100233990","effects-of-breathing-mild-bouts-of-low-oxygen-on-limb-mobility-after-spinal-injury-100233990",false,"NCT02323945","Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury","Mechanisms of Intermittent Hypoxia-induced Motor Recovery in Persons With SCI","Inclusion Criteria:\n\n* Age 18 and 75 years (the latter to reduce likelihood of heart disease)\n* Medical clearance to participate\n* Lesion at or below C2 and above T12 with non-progressive etiology\n* Classified as motor-incomplete with visible volitional leg movement\n* Injury greater than 1 year\n\nExclusion Criteria:\n\n* Concurrent severe medical illness (i.e., infection, cardiovascular disease, ossification, recurrent autonomic dysreflexia, unhealed decubiti, and history of pulmonary complications)\n* Pregnant women because of the unknown affects of AIH on pregnant women and fetus\n* History of seizures, brain injury, and\u002For epilepsy\n* Undergoing concurrent physical therapy\n* Diabetes\n* Cirrhosis\n* Caffeine and\u002For NSAID allergies or intolerances",true,"ALL","18 Years","75 Years",{"count":92,"type":93},44,"ESTIMATED","INTERVENTIONAL",[96],"NA","Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand the mechanisms by which intermittent hypoxia enhances motor function and spinal plasticity (ability of the nervous system to strengthen neural pathways based on new experiences) following SCI.",[99],"Spinal Cord Injuries",[101,102,103,104,105],"acute intermittent hypoxia","incomplete spinal cord injury","strength","walking","breathing","2026-03-18",{"date":108,"type":109},"2026-03-20","ACTUAL",{"date":111,"type":31},"2014-10",{"date":113,"type":93},"2027-11",{"name":5,"class":6},1]