[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574196":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":41,"responsibleParty":117,"collaborators":121,"id":131,"slug":132,"hasResults":133,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":26,"eligibilityCriteria":137,"healthyVolunteers":133,"sex":138,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":26,"studyType":144,"phases":145,"briefSummary":147,"conditions":148,"keywords":26,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":161},{"fullName":5,"class":6},"Air Force Military Medical University, China","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cognitive behavioural therapy mobile application","EXPERIMENTAL","All patients received standard first-line treatment for FD, including PPIs and\u002For prokinetics, which was at the discretion of physicians. Additionally, patients underwent mobile app (named LotusHope)-based CBT to learn or practice the skills of acceptance, cognition, values, goal-setting and behavioral exercises. It takes approximately 15-20 minutes to complete one CBT treatment per day. The mobile app-based interference will last for 8 weeks.",[13],"Procedure: cognitive behavioural therapy mobile application",{"label":15,"type":16,"description":17,"interventionNames":18},"Flupentixol and Melitracen Tablets","PLACEBO_COMPARATOR","All patients received standard first-line treatment for FD, including PPIs and\u002For prokinetics, which was at the discretion of physicians. Patients also took 1-2 tablets of deanxit (a compound preparation of tricyclic antidepressant (melitracen) and antipsychotic drug(flupentixol)) orally for 8 weeks.",[19],"Drug: Flupentixol and Melitracen Tablets",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","cognitive behavioural therapy mobile application","The CBT mobile application enables patients to conduct cognitive therapy independently.",[9],null,{"type":28,"name":15,"description":29,"armGroupLabels":30,"otherNames":26},"DRUG","patients take Flupentixol and Melitracen Tablets",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Yanglin Pan, Professor","CONTACT","13991811225","yanglinpan@hotmail.com",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Xiaoyu Kang, MD, Ph.D","15291680602","kangxiaoyu@hotmail.com",[42,59,71,79,88,96,104],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Hainan General Hospital (Hainan Affifiliated Hospital ofHainan Medical University)","RECRUITING","Haikou","Hainan","570000","China","CN",{"type":51,"coordinates":52},"Point",[53,54],110.34651,20.03421,{"lat":54,"lon":53},[57],{"name":58,"role":34,"phone":26,"phoneExt":26,"email":26},"Na Liu, MD, Ph.D",{"facility":5,"status":44,"city":60,"state":61,"zip":62,"country":48,"countryCode":49,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Xi'an","Shaanxi","710032",{"type":51,"coordinates":64},[65,66],108.92861,34.25833,{"lat":66,"lon":65},[69],{"name":70,"role":34,"phone":35,"phoneExt":26,"email":36},"Yanglin Pan, MD",{"facility":72,"status":44,"city":60,"state":61,"zip":62,"country":48,"countryCode":49,"cosmosGeoPoint":73,"geoPoint":75,"contacts":76},"Shaanxi Second People's Hospital",{"type":51,"coordinates":74},[65,66],{"lat":66,"lon":65},[77],{"name":78,"role":34,"phone":26,"phoneExt":26,"email":26},"Limei Wang, MD, Ph.D",{"facility":80,"status":81,"city":60,"state":61,"zip":62,"country":48,"countryCode":49,"cosmosGeoPoint":82,"geoPoint":84,"contacts":85},"Tangdu Hospital","NOT_YET_RECRUITING",{"type":51,"coordinates":83},[65,66],{"lat":66,"lon":65},[86],{"name":87,"role":34,"phone":26,"phoneExt":26,"email":26},"Zhenxiong Liu, MD, Ph.D",{"facility":89,"status":44,"city":60,"state":61,"zip":62,"country":48,"countryCode":49,"cosmosGeoPoint":90,"geoPoint":92,"contacts":93},"Xi'an 986 Hospital",{"type":51,"coordinates":91},[65,66],{"lat":66,"lon":65},[94],{"name":95,"role":34,"phone":26,"phoneExt":26,"email":26},"Jun Wang, MD, Ph.D",{"facility":97,"status":81,"city":60,"state":61,"zip":62,"country":48,"countryCode":49,"cosmosGeoPoint":98,"geoPoint":100,"contacts":101},"Xi'an People's Hospital",{"type":51,"coordinates":99},[65,66],{"lat":66,"lon":65},[102],{"name":103,"role":34,"phone":26,"phoneExt":26,"email":26},"Rui Huang, MD, Ph.D",{"facility":105,"status":44,"city":106,"state":107,"zip":108,"country":48,"countryCode":49,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Mianyang Third Hospital","Mianyang","Sichuan","621000",{"type":51,"coordinates":110},[111,112],104.68168,31.46784,{"lat":112,"lon":111},[115],{"name":116,"role":34,"phone":26,"phoneExt":26,"email":26},"Long Zou, Ph.D",{"type":118,"investigatorFullName":119,"investigatorTitle":120,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Yanglin Pan","professor",[122,124,125,127,129,130],{"name":89,"class":123},"UNKNOWN",{"name":72,"class":123},{"name":126,"class":6},"Xi'an People's Hospital (Xi'an Fourth Hospital)",{"name":128,"class":6},"Tang-Du Hospital",{"name":43,"class":123},{"name":105,"class":123},"100574196","effects-of-cognitive-behavioral-therapy-through-a-mobile-app-on-patients-with-refractory-functional-dyspepsia-100574196",false,"NCT06756139","Effects of Cognitive Behavioral Therapy Through a Mobile App on Patients With Refractory Functional Dyspepsia","Effects of Cognitive Behavioral Therapy Through a Mobile App on Patients With Refractory Functional Dyspepsia: a Multicenter, Single-blinded, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age 18-80\n2. Refractory functional dyspepsia (patients with Rome IV functional dyspepsia remained symptomatic after treatment of 8 weeks of proton pump inhibitor and 4 weeks of prokinetics)\n3. Negative or unrelated-to-FD symptom findings of gastroscopy, upper abdominal ultrasound, Hp test and routine blood tests within the past 1 year.\n\nExclusion Criteria:\n\n1. Severe mental illness (PHQ-9 ≥20 or GAD-7 ≥15) or suicidal ideation;\n2. Known hp infection, active gastrointestinal peptic ulcer, cholecystitis, gallstones, suspected or known bowel obstruction, gastroparesis, major gastrointestinal surgery etc.;\n3. Known or suspected malignant tumor, significant heart\u002Fbrain\u002Fliver\u002Fkidney diseases, obvious hematologic abnormalities or endocrine diseases etc., which may be -related to FD symptoms;\n4. Known or suspected drug-related FD (e.g.NSAIDs-related FD);\n5. Unable to access to mobile networks or unable to manage mobile APP properly.\n6. Allergy or other contradictions to flupenthixol or melitracen\n7. Taking any antipsychotics drugs or CBT interference within 12 weeks\n8. Pregnant or lactating women;\n9. Unable to provide informed consent.","ALL","18 Years","80 Years",{"count":142,"type":143},88,"ESTIMATED","INTERVENTIONAL",[146],"NA","Functional dyspepsia (FD) is a common gastrointestinal disease, which is associated with decreased life quality and increased medical cost. Antipsychotic drugs were demonstrated to be effective in relieving symptoms in FD patients, especially for patients with refractory FD. However, the use of those drugs was associated with obvious adverse events. Cognitive behavioral therapy (CBT) has extensive applications and exhibited potential treatment effects in clinical practices, especially for treating anxiety, depression, pain or stress disorders. Several previous RCT studies have confirmed the effects of psychological intervention on improving dyspepsia in FD patients. Our hypothesis was that 8-week smartphone-based CBT would be non-inferior to conventional pharmacotherapy in reducing FD-related symptoms in patients with refactory FD.",[149,150,151],"Functional Dyspepsia","Self-help Mobile Cognitive Behavioral Therapy","Antipsychotic Drug","2025-06-27",{"date":154,"type":155},"2025-07-01","ACTUAL",{"date":157,"type":155},"2024-11-01",{"date":159,"type":143},"2025-11-01",{"name":5,"class":6},7]