[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637590":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":41,"collaborators":26,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":26,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":26,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":71,"overallStatus":79,"whyStopped":26,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":26},{"fullName":5,"class":6},"University of Windsor","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Creatine Monohydrate + Heat Exposure","EXPERIMENTAL","Participants assigned to this arm will complete a 7-day creatine monohydrate loading phase followed by daily maintenance supplementation during a 7-day heat acclimation protocol. Participants will complete daily supervised heat exposure sessions consisting of cycling exercise in a controlled hot environment.",[13],"Dietary Supplement: Creatine Monohydrate",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo + Heat Exposure","PLACEBO_COMPARATOR","Participants assigned to this arm will consume a placebo supplement (maltodextrin) matched in appearance and dosing schedule to the creatine condition during a 7-day heat acclimation protocol. Participants will complete daily supervised heat exposure sessions consisting of cycling exercise in a controlled hot environment.",[19],"Dietary Supplement: Maltodextrin (Placebo)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Creatine Monohydrate","Participants assigned to this intervention will consume micronized creatine monohydrate during a 7-day loading phase at 0.3 g·kg-¹·day-¹ followed by a maintenance dose of 0.03 g·kg-¹·day-¹ during the heat acclimation protocol. Supplements will be dissolved in orange juice and consumed under supervision during laboratory visits. Creatine supplementation will continue throughout the heat acclimation period.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Maltodextrin (Placebo)","Participants will consume maltodextrin matched to creatine supplementation appearance and dosing schedule during the loading and maintenance phases of the study.",[15],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Andrew S Perrotta, Phd","CONTACT","604 679 7172","Andrew.Perrotta@uwindsor.ca",{"name":38,"role":34,"phone":39,"phoneExt":26,"email":40},"Benjamin R Tilson, (BSc)","519 819 7732","tilsonb@uwindsor.ca",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Dr. Andrew S. Perrotta","Assistant Professor, Department of Kinesiology, University of Windsor","100637590","effects-of-creatine-and-heat-exposure-on-exercise-performance-and-body-water-distribution-100637590",false,"NCT07593014","Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution","Creatine Monohydrate Supplementation During Repeated Heat Exposure: Effects on Fluid Balance and Exercise Performance in a Randomized Double-Blind, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Healthy biological males between 18 and 27 years of age\n* Recreationally active males and varsity athletes\n* Able to safely participate in moderate-intensity exercise and heat exposure\n* Willing to maintain habitual diet and physical activity throughout the study\n* Willing to refrain from additional dietary supplementation during study participation\n* Able to attend all required laboratory visits and heat exposure sessions\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* History of cardiovascular, metabolic, respiratory, renal, neurological, or heat-related illness\n* Contraindications to exercise testing or heat exposure identified during health screening\n* Current musculoskeletal injury limiting exercise participation\n* Current use of creatine supplementation or inability to complete the required washout period\n* Current use of medications or supplements known to affect hydration, thermoregulation, cardiovascular function, or exercise performance\n* Known allergy or intolerance to creatine monohydrate, maltodextrin, or orange juice\n* Inability to comply with study procedures or supplementation protocol\n* Resting tympanic temperature ≥38.0°C prior to a heat exposure session\n* Participation in another research study that may interfere with this protocol",true,"MALE","18 Years","27 Years",{"count":57,"type":58},25,"ESTIMATED","INTERVENTIONAL",[61],"NA","The goal of this clinical trial is to learn whether creatine supplementation changes how the body adapts to repeated exercise in the heat in healthy recreationally active adults and varsity athletes. The study will also examine whether creatine affects fluid balance, blood volume changes and exercise performance.\n\nThe main questions it aims to answer are:\n\nDoes creatine supplementation increase plasma volume and total body water during repeated heat exposure more than placebo? Does creatine supplementation improve exercise performance after heat acclimation more than placebo? Does creatine supplementation influence cardiovascular responses to heat stress?\n\nResearchers will compare a creatine supplementation group to a placebo group to determine whether creatine changes the magnitude of heat acclimation adaptations.\n\nParticipants will:\n\nComplete baseline measurements of body composition, hydration, blood markers, and exercise performance.\n\nConsume either creatine monohydrate or a placebo supplement daily Complete repeated supervised exercise sessions in a controlled heated environment Undergo repeated assessments of body water, temperature, heart rate, and exercise performance throughout the study",[64,65,66,67,68,69,70],"Heat Exposure","Exercise Performance","Hydration","Body Fluid Compartments","Creatine Supplementation","Placebo - Control","Plasma Volume",[23,64,72,73,70,74,67,75,76,77,78],"Heat Acclimation","Short Term Heat Acclimation","Fluid Balance","Wingate Test","VO2 Max","Cardiorespiratory Performance","Musculoskeletal Performance","NOT_YET_RECRUITING","2026-05-11",{"date":82,"type":83},"2026-05-18","ACTUAL",{"date":85,"type":58},"2026-07-30",{"date":87,"type":58},"2027-08-30",{"name":5,"class":6}]