[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635233":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":44,"centralContacts":52,"locations":60,"responsibleParty":78,"collaborators":80,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":33,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":33,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":108,"overallStatus":63,"whyStopped":33,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":130},{"fullName":5,"class":6},"University of Glasgow","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Butter","EXPERIMENTAL","Following a one week run-in period (habitual diet), participants will be assigned to consume butter as their primary dietary fat.",[13],"Other: Butter",{"label":15,"type":10,"description":16,"interventionNames":17},"Coconut Oil","Following a one week run-in period (habitual diet), participants will be assigned to consume coconut oil as their primary dietary fat.",[18],"Other: Coconut oil",{"label":20,"type":10,"description":21,"interventionNames":22},"Extra Virgin Olive Oil","Following a one week run-in period (habitual diet), participants will be assigned to consume olive oil as their primary dietary fat.",[23],"Other: Extra Virgin Olive Oil",{"label":25,"type":10,"description":26,"interventionNames":27},"Sunflower Oil","Following a one week run-in period (habitual diet), participants will be assigned to consume sunflower oil as their primary dietary fat.",[28],"Other: Sunflower Oil",[30,34,38,41],{"type":6,"name":9,"description":31,"armGroupLabels":32,"otherNames":33},"Participants will consume approximately 65 g\u002Fday of butter as their primary dietary fat for 14 days, replacing most habitual dietary fat intake.",[9],null,{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"Coconut oil","Participants will consume approximately 55 g\u002Fday of coconut oil as their primary dietary fat for 14 days, replacing most habitual dietary fat intake.",[15],{"type":6,"name":20,"description":39,"armGroupLabels":40,"otherNames":33},"Participants will consume 60 mL\u002Fday of olive oil as their primary dietary fat for 14 days, replacing most habitual dietary fat intake.",[20],{"type":6,"name":25,"description":42,"armGroupLabels":43,"otherNames":33},"Participants will consume 60 mL\u002Fday of sunflower oil as their primary dietary fat for 14 days, replacing most habitual dietary fat intake.",[25],[45,48,50],{"name":46,"affiliation":5,"role":47},"Athanasios Koutsos","PRINCIPAL_INVESTIGATOR",{"name":49,"affiliation":5,"role":47},"Dalia Malkova, PhD",{"name":51,"affiliation":5,"role":47},"Konstantinos Gerasimidis, PhD",[53,58],{"name":54,"role":55,"phone":56,"phoneExt":33,"email":57},"Linah Alhomidan","CONTACT","+447473477395","linahalhomidan@gmail.com",{"name":46,"role":55,"phone":33,"phoneExt":33,"email":59},"Athanasios.Koutsos@glasgow.ac.uk",[61],{"facility":62,"status":63,"city":64,"state":33,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"New Lister Building, Glasgow Royal Infirmary, 10-16 Alexandra Parade, G31 2ER","RECRUITING","Glasgow","G31 2ER","United Kingdom","UK",{"type":69,"coordinates":70},"Point",[71,72],-4.25763,55.86515,{"lat":72,"lon":71},[75,77],{"name":46,"role":55,"phone":76,"phoneExt":33,"email":59},"138629-01",{"name":46,"role":47,"phone":33,"phoneExt":33,"email":33},{"type":47,"investigatorFullName":46,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"Lecturer in Human Nutrition",[81,84],{"name":82,"class":83},"Dr Dalia Malkova","UNKNOWN",{"name":85,"class":83},"Professor Konstantinos Gerasimidis","100635233","effects-of-dietary-fats-on-gut-microbiota-composition-and-metabolic-activity-in-healthy-adults-100635233",false,"NCT07550023","Effects Of Dietary Fats on Gut Microbiota Composition and Metabolic Activity in Healthy Adults","Inclusion Criteria:\n\n* Adults aged 20-50 years\n* Body mass index (BMI) between 20 and 30 kg\u002Fm²\n* Generally healthy\n* Stable body weight (±2 kg) over the past 2 months\n* Living in the Glasgow area\n* Non-smoker\n\nExclusion Criteria:\n\n* Use of antibiotics within the past 3 months\n* Current use of medications affecting gut microbiota or cardiometabolic health\n* Regular use of dietary supplements that may influence study outcomes (e.g. probiotics, prebiotics, vitamins, minerals, fish oil), unless willing to discontinue prior to study start\n* Presence of chronic gastrointestinal, metabolic, cardiovascular, hepatobiliary, or pancreatic disease\n* History of major gastrointestinal surgery\n* Diagnosed diabetes or use of lipid-lowering therapy\n* Known fat malabsorption disorders\n* Pregnant or lactating women\n* Post-menopausal women\n* Following a restrictive or specific diet (e.g. vegan, ketogenic diet)\n* Food allergies or intolerances relevant to study interventions (e.g. dairy, coconut)\n* Recent significant weight change (±2 kg in the past month)\n* High reliance on ready meals or takeaway foods (\\>7 main meals per week)\n* Participation in another research study that may interfere with this study",true,"ALL","20 Years","50 Years",{"count":97,"type":98},64,"ESTIMATED","INTERVENTIONAL",[101],"NA","This study will investigate how adding a specific type of dietary fat to daily meals for two weeks affects the gut bacteria and their activity. Participants will be randomly assigned to consume one of four types of fat: butter, coconut oil, olive oil, or sunflower oil (60 mL each day for 2 weeks). Stool and blood samples (after an overnight fast) will be collected at 3 time points during the study (Days 1, 7, and 22). These samples will be used to measure metabolites produced by gut bacteria, the types of bacteria present in the gut, blood lipids, and inflammatory markers. The study, based on previous in vitro findings, aims to understand whether different types of fats (based on their structure and level of saturation) have different effects on gut bacteria and their activity in healthy subjects.",[104,105,106,107],"Short Chain Fatty Acids Concentration in Stools","Gut Microbiota Diversity and Composition","Blood Lipid Profiles","Inflammation Biomarkers",[109,110,111,112,113,114,115,116,9,117,35,118,119,120],"Gut microbiome","Gut microbiota","Dietary fat","Short-chain fatty acids","SCFA","Saturated fat","Monounsaturated fat","Polyunsaturated fat","Olive oil","Sunflower oil","MUFA","PUFA","2026-04-17",{"date":123,"type":124},"2026-04-24","ACTUAL",{"date":126,"type":124},"2026-03-23",{"date":128,"type":98},"2028-03-31",{"name":5,"class":6},1]