[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643882":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":35,"locations":30,"responsibleParty":41,"collaborators":30,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":30,"eligibilityCriteria":50,"healthyVolunteers":47,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":30,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":30,"overallStatus":63,"whyStopped":30,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":30},{"fullName":5,"class":6},"Huazhong University of Science and Technology","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"placebo acupuncture group","PLACEBO_COMPARATOR","nonpenetrating placebo needles",[13],"Device: Placebo Group",{"label":15,"type":16,"description":17,"interventionNames":18},"acupuncture group 1","EXPERIMENTAL","indwelling intradermal needles",[19],"Device: acupuncture group 1",{"label":21,"type":16,"description":22,"interventionNames":23},"acupuncture group 2","combining fire needle and regular acupuncture",[24],"Device: acupuncture group 2",[26,31,33],{"type":27,"name":28,"description":11,"armGroupLabels":29,"otherNames":30},"DEVICE","Placebo Group",[9],null,{"type":27,"name":15,"description":17,"armGroupLabels":32,"otherNames":30},[15],{"type":27,"name":21,"description":22,"armGroupLabels":34,"otherNames":30},[21],[36],{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},"Pu Zhou","CONTACT","+8602783662379","tongjihlunli@163.com",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"SPONSOR_INVESTIGATOR","Cui Hong Zheng","Clinical professor, principal investigator","100643882","effects-of-different-acupuncture-techniques-on-the-success-rate-in-patients-with-recurrent-implantation-failure-100643882",false,"NCT07669623","Effects of Different Acupuncture Techniques on the Success Rate in Patients With Recurrent Implantation Failure","Inclusion Criteria:\n\n1. Meets the criteria for RIF diagnosis (≥ 2 instances of unsuccessful transfer of high-quality embryos).\n2. Age: 20 to 40 years old.\n3. Planning for a cycle involving the transfer of frozen-thawed embryos (FET).\n4. Possession of a transplantable D3 frozen embryo (≥6 cells) or a frozen blastocyst (≥3BC).\n5. Estradiol-progesterone replacement therapy: endometrial thickness ≥ 7 mm within the period of endometrial transformation.\n\nExclusion Criteria:\n\n1. Individuals planning to undergo preimplantation genetic diagnosis (PGD).\n2. Recipients of egg donations.\n3. Chromosomal abnormalities in either spouse or one partner (excluding chromosomal polymorphisms).\n4. Patients with known embryo-related factors leading to implantation failure.\n5. Abnormalities of the uterus that may affect implantation (including uterine malformations, uterine tuberculosis, submucosal myomas, severe uterine adhesions, severe uterine endometriosis, myomas with a diameter of ≥4 cm, and so on).\n6. Abnormalities in immunity and blood coagulation\n7. Recurrent spontaneous abortions (loss of a fetus before 28 weeks of gestation occurring twice or more).\n8. Individuals with other endocrine disorders, such as thyroid disorders, hyperprolactinemia, insulin resistance, diabetes, and adrenal disorders, whose hormone levels have not been well-controlled over the past 3 months.\n9. Individuals with untreated hydrosalpinx;\n10. Individuals with a Body Mass Index (BMI) below 18 and above 25 kg\u002F m2.\n11. Men with severe abnormalities in semen quality. Individuals with a history of needle phobia.","FEMALE","20 Years","40 Years",{"count":55,"type":56},312,"ESTIMATED","INTERVENTIONAL",[59],"NA","To conduct a multi-center, randomized, controlled clinical study aimed at formally evaluating the impact of different acupuncture methods on the success rate in patients with recurrent implantation failure",[62],"Implantation Failure","NOT_YET_RECRUITING","2026-06-20",{"date":66,"type":67},"2026-06-25","ACTUAL",{"date":69,"type":56},"2026-07-01",{"date":71,"type":56},"2029-06-30",{"name":43,"class":6}]