[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558153":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":39,"locations":45,"responsibleParty":62,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":30,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":30,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":30,"overallStatus":48,"whyStopped":30,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Inner Mongolia University of Science and Technology","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"PC Ventilation mode group","EXPERIMENTAL","Group I patients received mechanical ventilation using the PC mode. The anesthetic machine (MAQUET Flow-I, Italy) parameters were set as follows: The inspiratory pressure (Pins) was adjusted to maintain an end-tidal carbon dioxide concentration (ETCO2) of 4.0-5.0 kPa. Pure oxygen and air were utilized at 0.3 L\u002Fmin each, with an oxygen content of 41%.",[13],"Device: PC Ventilation mode",{"label":15,"type":10,"description":16,"interventionNames":17},"VC Ventilation mode group","Group II patients received mechanical ventilation in VC mode. The tidal volume during regulated breathing was determined based on the ideal body weight (IBW): 6-8 ml\u002Fkg (IBW for males: 50 + 0.91 × (height \\[cm\\] - 152.4); IBW for females: 45.5 + 0.91 × (height \\[cm\\] - 152.4). The positive end-expiratory pressure (PEEP) was set at 10 cmH2O, with an inspiration-to-expiration ratio of 1:2, a respiratory rate of 16 breaths per minute, and an oxygen content of 41%",[18],"Device: VC Ventilation mode",{"label":20,"type":10,"description":21,"interventionNames":22},"PRVC Ventilation mode group","Group III patients received mechanical ventilation using the PRVC mode.The tidal volume during regulated breathing was determined based on the ideal body weight (IBW): 6-8 ml\u002Fkg (IBW for males: 50 + 0.91 × (height \\[cm\\] - 152.4); IBW for females: 45.5 + 0.91 × (height \\[cm\\] - 152.4). The positive end-expiratory pressure (PEEP) was set at 10 cmH2O, with an inspiration-to-expiration ratio of 1:2, a respiratory rate of 16 breaths per minute, and an oxygen content of 41%",[23],"Device: PRVC Ventilation mode",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","PC Ventilation mode","Patients were randomly assigned to three groups using a random number table and the random remainder grouping method at a ratio of 1:1:1. Group I received pressure control ventilation (PC).",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"VC Ventilation mode","Patients were randomly assigned to three groups using a random number table and the random remainder grouping method at a ratio of 1:1:1. Group II received volume control ventilation (VC).",[15],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"PRVC Ventilation mode","Patients were randomly assigned to three groups using a random number table and the random remainder grouping method at a ratio of 1:1:1. Group III received pressure-regulated volume control ventilation (PRVC).",[20],[40],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Yu-Long Jia","CONTACT","14747606821","jiayulong97@gmail.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Inner Mongolia Baogang Hospital","RECRUITING","Baotou","Inner Mongolia","014010","China","CN",{"type":55,"coordinates":56},"Point",[57,58],109.84389,40.6516,{"lat":58,"lon":57},[61],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},{"type":63,"investigatorFullName":41,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"SPONSOR_INVESTIGATOR","Principal Investigator",[66,67],{"name":47,"class":6},{"name":68,"class":6},"The Affiliated Hospital of Inner Mongolia Medical University","100558153","effects-of-different-anesthesia-machine-modalities-on-bariatric-surgery-patients-a-prospective-randomized-controlled-study-100558153",false,"NCT06547411","Effects of Different Anesthesia Machine Modalities on Bariatric Surgery Patients: a Prospective Randomized Controlled Study","Effects of Different Ventilation Modes on Intracranial Pressure and Carbon Dioxide Partial Pressure During Bariatric Surgery: a Prospective, Randomized, Controlled Study","Inclusion Criteria:\n\n* Patients scheduled for elective bariatric surgery.\n* Age between 16 and 65 years.\n* Continuous weight gain for more than 5 years with a BMI ≥ 35.\n* ASA-PS (American Society of Anesthesiologists Physical Status) categorization of Grade II or III.\n\nExclusion Criteria:\n\n* Patients who were dependent on alcohol or opioids.\n* Patients with severe mental or intellectual disabilities.\n* Patients with severe ocular conditions, such as ocular trauma, optic nerve tumors, or those wearing ocular prostheses.",true,"ALL","16 Years","65 Years",{"count":81,"type":82},90,"ESTIMATED","INTERVENTIONAL",[85],"NA","The goal of this clinical trial is to explore the clinical significance and value of the PRVC ventilation mode in Bariatric Surgery Patients. The main questions it aims to answer are：\n\n* Do different ventilation patterns affect intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients?\n* Does PRVC mode reduce intracranial pressure and partial pressure of carbon dioxide in bariatric surgery patients?\n* Whether intracranial pressure can be quickly measured by monitoring a patient's optic nerve sheath diameter (ONSD)？ Researchers randomized bariatric surgery patients into PC, VC, and PRVC groups for comparison, looking at breathing mechanics, PaCO2, and ICP.\n\nParticipants will:\n\n* take PC mode ventilation, VC mode ventilation, and PRVC mode ventilation\n* monitor Respiratory mechanics, PaCO2, and ONSD",[88,89,90,91],"Ventilation","Bariatric Surgery","Intracranial Pressure","Carbon Dioxide","2025-02-28",{"date":94,"type":95},"2025-03-05","ACTUAL",{"date":97,"type":95},"2024-03-01",{"date":99,"type":82},"2025-03-30",{"name":41,"class":6},1]