[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563028":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":27,"locations":36,"responsibleParty":51,"collaborators":53,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":10,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":10,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ENDS users",null,"Long-term stable users of electronic nicotine delivery systems, 21 years of age or older, who do not use combustible (conventional) cigarettes",[13],"Other: Health Assessments",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-users","Gender-matched control participants who do not use ENDS or combustible cigarettes",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Health Assessments","Participants will complete the blood tests, questionnaires, cardiovascular tests, and pulmonary test at visits 1, 2, and 4. Non-Contrast Chest CT and cardiopulmonary treadmill (VO2 max) stress tests will occur at visits 1 and 4. Visit 3 will not include cardiovascular and pulmonary tests.",[9,15],[24],{"name":25,"affiliation":5,"role":26},"Timothy Baker, PhD","PRINCIPAL_INVESTIGATOR",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"James Stein, MD","CONTACT","608-262-2075","jhs@medicine.wisc.edu",{"name":25,"role":30,"phone":34,"phoneExt":10,"email":35},"503-387-5167","tbb@ctri.wisc.edu",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":10},"UW Center for Tobacco Research and Intervention","RECRUITING","Madison","Wisconsin","53711","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-89.40123,43.07305,{"lat":49,"lon":48},{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[54],{"name":55,"class":56},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100563028","effects-of-e-cigarette-use-on-health-100563028",false,"NCT06610838","Effects of E-cigarette Use on Health","Longitudinal Effects of E-cigarette Use on Cardiovascular and Pulmonary Health","VAPECHECK","Inclusion Criteria:\n\n* greater than or equal to 21 years of age\n* has vaped a nicotine e-cigarette product at least 2 days\u002Fweek for most weeks for greater than or equal to 12 months\n* plans to remain in catchment area for greater than or equal to 3 years\n* smoked 5 or fewer tobacco cigarettes in the past 6 months\n* no serious CV, pulmonary, or other medical problems\n* not currently pregnant\n* no plans to stop vaping\n\nExclusion Criteria:\n\n* serious CV, pulmonary, or other medical problems (e.g., moderate or severe aortic stenosis, class III or IV heart failure, blood pressure greater than or equal to 160\u002F100 mmHg, interstitial lung disease, sarcoidosis, Stage 3 or 4 cancer)\n* combusted or vaped cannabis use 3 days\u002Fweek or more in the past 3 months\n* currently pregnant\n* not able to read an write English\n* incarceration",true,"ALL","21 Years",{"count":69,"type":70},600,"ESTIMATED","OBSERVATIONAL","Electronic nicotine delivery systems (ENDS) are used by millions of Americans, however their long-term health effects are unknown. This research proposal will quantify the effects of long-term ENDS use on validated and novel biomarkers of cardiovascular and pulmonary disease and how they are influenced by use heaviness, age, body weight, and co-use of other products. This study will produce the most informative evidence to date on how long-term ENDS use affects cardiovascular and pulmonary health.",[74],"Electronic Cigarette Use","2025-12-23",{"date":77,"type":78},"2025-12-24","ACTUAL",{"date":80,"type":78},"2025-01-06",{"date":82,"type":70},"2029-06-30",{"name":5,"class":6},1]