[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100511456":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":45,"responsibleParty":63,"collaborators":43,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":43,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":43,"enrollmentInfo":76,"targetDuration":43,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":43,"overallStatus":47,"whyStopped":43,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Pusan National University Yangsan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Normal saline group","PLACEBO_COMPARATOR","Participants are administered 3mL of 0.9% normal saline at the end of anesthesia",[13],"Drug: normal saline",{"label":15,"type":16,"description":17,"interventionNames":18},"Flumazenil group","ACTIVE_COMPARATOR","Participants are administered 0.3mg(3mL) of flumazenil at the end of anesthesia",[19],"Drug: Flumazenil",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Flumazenil","During induction, patients will receive remimazolam 6mg\u002Fkg\u002Fh with remifentanil TCI 1\\~4 nanogram\u002FmL. After patient loses consciousness, anesthesia will be maintained with remimazolam 1-2mg\u002Fkg\u002Fh combined with remifentanil. When procedure ends, infusion remimazolam stops and 0.3mg of flumazenil according to allocated groups.",[15],[27],"Flumazenil, Flunil, Bukwang Pharm Co., Ltd",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"normal saline","During induction, patients will receive remimazolam 6mg\u002Fkg\u002Fh with remifentanil TCI 1\\~4 nanogram\u002FmL. After patient loses consciousness, anesthesia will be maintained with remimazolam 1-2mg\u002Fkg\u002Fh combined with remifentanil. When procedure ends, infusion remimazolam stops and 0.9% normal saline according to allocated groups.",[9],[33],"Normal saline inj (JW)",[35],{"name":36,"affiliation":5,"role":37},"Sangwook Shin, MD. PhD","STUDY_DIRECTOR",[39],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Jaesang BAE, MD","CONTACT","820553602129",null,"wotkdqo@gmail.com",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":43,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Yangsan","Gyeongsangnam-do","50612","South Korea",{"type":53,"coordinates":54},"Point",[55,56],129.03358,35.34199,{"lat":56,"lon":55},[59],{"name":60,"role":41,"phone":61,"phoneExt":43,"email":62},"SANGWOOK SHIN, MD, PhD","82-055-360-2129","shinsw@pusan.ac.kr",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"PRINCIPAL_INVESTIGATOR","SANGWOOK SHIN","Professor","100511456","effects-of-flumazenil-on-recovery-after-total-intravenous-anesthesia-with-remimazolam-100511456",false,"NCT05939674","Effects of Flumazenil on Recovery After Total Intravenous Anesthesia With Remimazolam","Effects of Flumazenil on Recovery After Total Intravenous Anesthesia With Remimazolam in Elderly Patients Undergoing Hip Joint Surgery: a Prospective Randomized Controlled Study.","Inclusion Criteria:\n\n* Patients over 65 years old scheduled for hip joint surgery\n\nExclusion Criteria:\n\n* Patients with impaired consciousness or delirium before surgery\n* Patients who are hemodynamically unstable before surgery\n* Patients with a history of neurological or neuromuscular disorders or use of medications that affect neurological or neuromuscular function\n* Patients who have taken sedatives (anti-anxiety medications, antipsychotics, antidepressants, sleep aids) within the past 24 hours\n* Patients with known allergy to benzodiazepine, flumazenil\n* Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption\n* Patients with hypersensitivity to Dextran40\n* Patients who have been taking benzodiazepine for long term\n* Patients with end stage renal disease requiring hemodialysis\n* Patients with history of acute angle glaucoma\n* Patients with alcohol or substance dependence\n* ASA classification 4 or 5","ALL","65 Years",{"count":77,"type":78},24,"ESTIMATED","INTERVENTIONAL",[81],"NA","Remimazolam is a medication that has the advantage of a short half-life and reversibility with flumazenil. In clinical situations, the use of flumazenil for the reversal of sedation is common, but there is no precise indication for its administration. In this study, we aim to investigate the necessity of routine flumazenil use after administering remimazolam for intravenous anesthesia.",[84,85,86,87],"Flumazenil Adverse Reaction","Remimazolam","Hip Joint","Elderly Patients","2025-09-07",{"date":90,"type":91},"2025-09-12","ACTUAL",{"date":93,"type":91},"2023-09-19",{"date":95,"type":78},"2026-06",{"name":5,"class":6},1]