[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608321":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":25,"locations":25,"responsibleParty":26,"collaborators":25,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":35,"acronym":25,"eligibilityCriteria":36,"healthyVolunteers":32,"sex":37,"minAge":38,"maxAge":25,"enrollmentInfo":39,"targetDuration":25,"studyType":42,"phases":43,"briefSummary":45,"conditions":46,"keywords":48,"overallStatus":52,"whyStopped":25,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":25},{"fullName":5,"class":6},"Capital Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"IMT group","EXPERIMENTAL","In this group, external load, initially 50%MIP , was daily adjusted to the highest tolerable load. The training is carried out 5 days a week for 8 weeks. The patient's MIP is measured every two weeks to adjust the training parameters in a timely manner to suit the patient's condition.",[13],"Behavioral: inspiratory muscle training",{"label":15,"type":16,"description":17,"interventionNames":18},"sham-IMT group","SHAM_COMPARATOR","In this group, external load and maximal 10% MIP remained unadjusted. The training is carried out 5 days a week. The patient's MIP is measured every two weeks to adjust the training parameters in a timely manner to suit the patient's condition.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","inspiratory muscle training","This intervention will include a long term program of 8 weeks IMT in PMV patients who these patients who have required at least 6h of mechanical ventilation for 21 consecutive days.",[9,15],null,{"type":27,"investigatorFullName":28,"investigatorTitle":29,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Shuo Chen","Principal Investigator","100608321","effects-of-imt-on-weaning-and-diaphragmatic-function-in-pmv-patients-100608321",false,"NCT07200037","Effects of IMT on Weaning and Diaphragmatic Function in PMV Patients","Effects of Inspiratory Muscle Training on Weaning and Diaphragmatic Function in Prolonged Mechanical Ventilation Patients: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients who received therapy in the HDU of the Respiratory Rehabilitation Center of Beijing Rehabilitation Hospital Affiliated to Capital Medical University and met the PMV criteria clearly recommended by the NAMDRC consensus in 2005, which is \"mechanical ventilation for at least 6 hours a day for 21 consecutive days\".\n\n  * The patients' conditions were relatively stable, they were conscious, had no intellectual disability, no mental illness, no cognitive impairment, and gave informed consent.\n\n    * They had spontaneous breathing and could tolerate short periods of being off the ventilator to complete the training.\n\n      * The ventilator parameters met the following requirements: PEEP ≤ 10 cmH2O, FiO2 \\\u003C 0.60, RR \\\u003C 25.\n\nExclusion Criteria:\n\n1\\) brain injuries, pulmonary contusions and lacerations, rib fractures, unhealed wounds in the chest and abdomen, etc. The condition is severe, and inspiratory muscle training and diaphragm ultrasound assessment cannot be performed. 2) No spontaneous breathing, completely dependent on mechanical ventilation; 3) Pre-existing pulmonary infection or severe heart, lung or kidney diseases before clinical trials, with unstable hemodynamics; 4) Poor cognitive function, poor compliance, and non-cooperation with treatment.-","ALL","18 Years",{"count":40,"type":41},120,"ESTIMATED","INTERVENTIONAL",[44],"NA","Prolonged mechanical ventilation (PMV) and weaning failure can lead to extended hospital stays, as well as increased morbidity and mortality during hospitalization. Therefore, PMV not only increases the economic burden on patients and their families, but also adds to the societal economic burden and consumes critical care medical resources. Inspiratory muscle training (IMT) is widely used by physical therapists in critically ill patients to improve respiratory function and enhance quality of life. IMT helps improve diaphragmatic function, and the improvement of diaphragmatic function in turn promotes better respiratory function, which is clinically significant for accelerating weaning. However, most studies on the effects of IMT on weaning success rates and the duration of mechanical ventilation have limitations such as small sample sizes, homogeneous patient populations, and short intervention periods. As a result, there is still no unified, high-quality evidence-based consensus. The purpose of this study is to further clarify the role of IMT in improving diaphragmatic function and increasing weaning success rates in patients with prolonged weaning, through clinical treatment and the collection and analysis of relevant data.",[47],"Prolonged Mechanical Ventilation",[49,50,51],"Inspiratory muscle training","Prolonged mechanical ventilation","weaning","NOT_YET_RECRUITING","2025-09-28",{"date":55,"type":56},"2025-09-30","ACTUAL",{"date":58,"type":41},"2025-10-01",{"date":60,"type":41},"2026-09-01",{"name":5,"class":6}]