[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530458":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":40,"responsibleParty":58,"collaborators":25,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":25,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of Nove de Julho","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Therapeutic exercise group","ACTIVE_COMPARATOR","The therapeutic exercise program will include warm-up, resistance, neuromuscular, mobility, and balance exercises. Over ten weeks, two sessions of the therapeutic exercise program will be carried out individually, lasting approximately 60 minutes each-a total of 20 therapeutic exercise sessions. Therapeutic exercise sessions will be carried out at least 24 hours between sessions. The therapeutic exercises will be performed in up to three sets of 8-12 repetitions or 30-60 seconds each, with rest intervals of 90 seconds between sets.",[13],"Other: Therapeutic exercises",{"label":15,"type":16,"description":17,"interventionNames":18},"Therapeutic exercise group and pain neuroscience education program","EXPERIMENTAL","The therapeutic exercise program will include warm-up, resistance, neuromuscular, mobility, and balance exercises. Over ten weeks, two sessions of the therapeutic exercise program will be carried out individually, lasting approximately 60 minutes each-a total of 20 therapeutic exercise sessions. Therapeutic exercise sessions will be carried out at least 24 hours between sessions. The therapeutic exercises will be performed in up to three sets of 8-12 repetitions or 30-60 seconds each, with rest intervals of 90 seconds between sets. The chronic pain neuroscience education program will be based on three domains. Making sense of pain, exposure with control, and lifestyle changes.",[13,19],"Other: Therapeutic exercises + pain neuroscience education program",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Therapeutic exercises","The therapeutic exercise program will include warm-up, resistance, neuromuscular, mobility, and balance exercises. Over ten weeks, two sessions of the therapeutic exercise program will be carried out individually, lasting approximately 60 minutes each-a total of 20 therapeutic exercise sessions. Therapeutic exercise sessions will be carried out at least 24 hours between sessions. Therapeutic exercises will be performed in up to three sets of 8-12 repetitions or 30-60 seconds each, with rest intervals of 90 seconds between sets.",[9,15],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Therapeutic exercises + pain neuroscience education program","In addition to the therapeutic exercise protocol previously reported in the control group, research participants allocated to the experimental group will undergo an education program in the neurosciences of chronic pain carried out one day a week between the two therapeutic exercise sessions lasting ten weeks.\n\nThe chronic pain neuroscience education program will be based on three domains. Making sense of pain, Exposure with control, and Lifestyle changes also urge modifications aimed at improving sleep, stress, and anxiety.",[15],[31],{"name":32,"affiliation":33,"role":34},"Cid Gomes, PhD","Nove de Julho University","PRINCIPAL_INVESTIGATOR",[36],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+5511970941936","cid.andre@gmail.com",[41],{"facility":33,"status":42,"city":43,"state":25,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","São Paulo","01504-001","Brazil","BR",{"type":48,"coordinates":49},"Point",[50,51],-46.63611,-23.5475,{"lat":51,"lon":50},[54,56],{"name":55,"role":37,"phone":25,"phoneExt":25,"email":25},"Cid Gomes",{"name":57,"role":34,"phone":25,"phoneExt":25,"email":25},"Cid Gomes, Phd",{"type":34,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Cid André Fidelis de Paula Gomes","Principal Investigator","100530458","effects-of-including-a-chronic-pain-neuroscience-education-program-for-individuals-with-knee-oa-100530458",false,"NCT06187038","Effects of Including a Chronic Pain Neuroscience Education Program for Individuals With Knee OA","Effects of Including a Chronic Pain Neuroscience Education Program for Individuals With Knee OA: Randomized, Blinded Clinical Trial","Inclusion Criteria:\n\n* A clinical diagnosis of knee osteoarthritis (knee pain for \\> 3 months\n* Morning stiffness \\\u003C30 minutes\n* Crepitus\n* Bone tenderness, and absence of palpable heat and\u002For diagnosis established radiographically (determined by Kellgren and Lawrence grade 1 to 3 on a scale 1 up to 4)\n\nExclusion Criteria:\n\n* Hip OA\n* severe osteoporosis\n* Fibromyalgia\n* Medical history of tumors or cancer\n* Active inflammatory joint diseases (rheumatoid arthritis, gout)\n* Undergoing any lower extremity joint replacement\n* Neurological diseases (Parkinson's disease, stroke, Multiple Sclerosis, muscular dystrophy, motor neuron disease, Alzheimer's disease, cognitive and cardiopulmonary impairment that may prevent or limit the performance of exercises, use of a gait assistance device, history of recent knee trauma.\n* Having undergone any form of treatment involving physiotherapy, intra-articular corticosteroids, anti-inflammatories or chondroprotective in the last six months","ALL","40 Years","80 Years",{"count":72,"type":73},92,"ESTIMATED","INTERVENTIONAL",[76],"NA","Research participants diagnosed with knee osteoarthritis will be randomized through a draw using sealed opaque envelopes indicating two groups: 1. therapeutic exercises, 2. therapeutic exercises + chronic pain neuroscience education program. The primary outcome will be functional performance using a patient-reported measure, the Knee Injury and Osteoarthritis Outcome Score (KOOS).\n\nThe selected secondary outcomes will be pain intensity by the numerical pain scale (END), physical function reported by the patient by the patient-specific functional scale (EFEP), Pain self-efficacy questionnaire (PSEQ), functional mobility by the timed up and test (TUG), general effect perceived through the global perception scale (EPG), muscle strength through Maximum Voluntary Isometric Contraction (MVIC) and functionality and disability through the World Health Organization Disability Assessment Schedule (WHODAS).",[79],"Osteoarthritis, Knee","2026-05-21",{"date":82,"type":83},"2026-05-22","ACTUAL",{"date":85,"type":83},"2024-05-28",{"date":87,"type":73},"2026-12-15",{"name":5,"class":6},1]