[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100489587":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":43,"responsibleParty":74,"collaborators":26,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":78,"sex":84,"minAge":85,"maxAge":26,"enrollmentInfo":86,"targetDuration":26,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":46,"whyStopped":26,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University Hospital, Angers","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Increase of MAP at low target 65-70 mmHg (with catecholamines or volemic expansion)","ACTIVE_COMPARATOR","Target of mean arterial pressure (MAP) at 65-70 mmHg The therapeutic means used to obtain the MAP objectives within each group (increase in catecholamines and \u002F or volume expansion) are left to the discretion of the clinician, in accordance with the recommendations.",[13],"Procedure: increase of mean arterial pressure at 65-70 mmHg",{"label":15,"type":16,"description":17,"interventionNames":18},"Increase of MAP at high target 80-85 mmHg (with catecholamines or volemic expansion)","EXPERIMENTAL","Target of mean arterial pressure (MAP) at 80-85 mmHg The therapeutic means used to obtain the MAP objectives within each group (increase in catecholamines and \u002F or volume expansion) are left to the discretion of the clinician, in accordance with the recommendations.",[19],"Procedure: increase of mean arterial pressure at 80-85 mmHg",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","increase of mean arterial pressure at 65-70 mmHg","Increase of mean arterial pressure at 65-70 mmHg (with catecholamines or volemic expansion at the discretion of the clinician)",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"increase of mean arterial pressure at 80-85 mmHg","Increase of mean arterial pressure at 80-85mmHg (with catecholamines or volemic expansion at the discretion of the clinician).",[15],[32],{"name":33,"affiliation":5,"role":34},"Pierre ASFAR, MD PhD","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Nicolas FAGE, MD","CONTACT","+332 41 35 36 37","nicolas.fage@chu-angers.fr",{"name":42,"role":38,"phone":39,"phoneExt":26,"email":26},"Ines ZIRIAT, MD",[44,61],{"facility":45,"status":46,"city":47,"state":26,"zip":26,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Angers University Hospital","RECRUITING","Angers","France","FR",{"type":51,"coordinates":52},"Point",[53,54],-0.55202,47.47156,{"lat":54,"lon":53},[57],{"name":58,"role":38,"phone":59,"phoneExt":26,"email":60},"Pierre ASFAR","02 41 35 58 65","PiAsfar@chu-angers.fr",{"facility":62,"status":46,"city":63,"state":26,"zip":26,"country":48,"countryCode":49,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Vendée Hospital","La Roche-sur-Yon",{"type":51,"coordinates":65},[66,67],-1.42757,46.66974,{"lat":67,"lon":66},[70],{"name":71,"role":38,"phone":72,"phoneExt":26,"email":73},"Jean-Claude LACHERADE","02 51 44 61 61","Jean-claude.lacherade@ght85.fr",{"type":75,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100489587","effects-of-increasing-mean-arterial-pressure-on-renal-function-in-patients-with-shock-and-with-elevated-central-venous-pressure-100489587",false,"NCT05655065","Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure","Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure : a Pilot Study for the Individualization of Mean Arterial Pressure","MAPAKI","Inclusion Criteria:\n\n* Adult patients (≥ 18 years old )\n* Arterial hypotension requiring the etablishment of catecholamines\n* Norepinephrine dose ⩾ 0.1µg\u002Fkg\u002Fmin at the inclusion\n* High central venous pressure ≥ 12mmHg\n* Cardiac output monitoring (PICCO or Swan Ganz)\n\nExclusion Criteria:\n\n* Anuria\n* Patient with an emergency indication of renal replacement therapy (severe hyperkalemia, severe metabolical acidosis with pH \\\u003C7.15, acute pulmonary edema due to fluid overload resulting in severe hypoxemia, serum urea concentration \\> 40 mmol\u002Fl)\n* Pregnant, lactating or parturient woman\n* Patient deprived of liberty by judicial or administrative decision\n* Patient with psychiatric compulsory care\n* Patient subject to legal protection measures\n* Patients with do-no-reanimate order or withdrawal of life sustaining support","ALL","18 Years",{"count":87,"type":88},30,"ESTIMATED","INTERVENTIONAL",[91],"NA","The purpose of this study is to assess the effect of a higher mean arterial pressure on renal function for patients with shock and elevated central venous pressure.",[94],"Shock",[96,97,98],"mean arterial pressure","central venous pressure","Renal function","2026-03-31",{"date":101,"type":102},"2026-04-06","ACTUAL",{"date":104,"type":102},"2023-01-02",{"date":106,"type":88},"2026-12-31",{"name":5,"class":6},2]