[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530015":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":38,"responsibleParty":56,"collaborators":24,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":24,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":24,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Qianfoshan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Individualized PEEP group","EXPERIMENTAL","After recruitment maneuver, PEEP is titrated decreasingly using driving pressure guided individualised PEEP ventilation strategy, and the PEEP corresponding to the lowest driving pressure is the individualised PEEP.",[13],"Procedure: Individualized PEEP group",{"label":15,"type":6,"description":16,"interventionNames":17},"Fixed PEEP group","After recruitment maneuver, PEEP is fixed at 8cmH2O.",[18],"Procedure: Fixed PEEP group",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Individualized PEEP group: Recruitment Maneuver (RM) is performed first. In pressure control mode, PEEP and airway plateau pressure are increased to 20 cmH2O and 35 cmH2O at a rate of 5 cmH2O every 30s, and driving pressure is maintained at 15 cmH2O throughout. Subsequently, in volume-controlled ventilation mode, PEEP decreases from 20 cmH2O to 4 cmH2O at gradient of 2 cmH2O, and each PEEP level is maintained for 30s. The PEEP corresponding to the lowest driving pressure is the individualized PEEP we need. If multiple PEEP levels showed the same lowest driving pressure, the lowest PEEP value as the individualized PEEP. The above procedures are performed three times during the surgery (5 minutes after intubation,5 minutes after the beginning of pneumoperitoneum, and 5 minutes after the end of pneumoperitoneum).",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"After the same RM, PEEP is fixed at 8 cmH2O.",[15],[29],{"name":30,"affiliation":31,"role":32},"yong t Sun, Ph.D","Shandong First Medical University","STUDY_CHAIR",[34],{"name":30,"role":35,"phone":36,"phoneExt":24,"email":37},"CONTACT","18660795201","sunyongtao1979@163.com",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University","RECRUITING","Jinan","Shandong","250014","China","CN",{"type":48,"coordinates":49},"Point",[50,51],116.99722,36.66833,{"lat":51,"lon":50},[54],{"name":55,"role":35,"phone":36,"phoneExt":24,"email":37},"yong T Sun, PH.D",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","Yongtao Sun","professor","100530015","effects-of-individualized-peep-guided-by-driving-pressure-on-postoperative-atelectasis-in-patients-with-morbid-obesity-100530015",false,"NCT06181279","Effects of Individualized PEEP Guided by Driving Pressure on Postoperative Atelectasis in Patients With Morbid Obesity","Effects of Individualized Positive End-expiratory Pressure Guided by Driving Pressure on Postoperative Atelectasis After Bariatric Surgery in Patients With Morbid Obesity: A Single-center, Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n* Age 18 to 60 years old;\n* Body mass index (BMI) ≥ 40 kg\u002Fm2;\n* ASA classification I to III;\n* Signing the informed consent form for this clinical study;\n\nExclusion Criteria:\n\n* Respiratory infection within 4 weeks; severe respiratory system diseases; history of pulmonary and\u002For thoracic surgery; neuromuscular dysfunction;\n* Serious cardiac, renal or haematopoietic diseases;\n* Contraindications to PEEP；","ALL","18 Years","60 Years",{"count":71,"type":72},52,"ESTIMATED","INTERVENTIONAL",[75],"NA","Atelectasis is a common complication in patients undergoing surgery under general anesthesia, particularly in obese patients. Postoperative atelectasis could last for more than 24h and contribute to a variety of other complications, including hypoxemia and pneumonia. We plan to conduct a single-center, randomized controlled trial in patients undergoing bariatric surgery to test the hypothesis that driving pressure guided PEEP could reduce the postoperative atelectasis.",[78,79],"Pulmonary Atelectasis","Obesity, Morbid",[81,82,83],"Individual Positive End-expiratory Pressure","Driving Pressure","Ventilator-induced Lung Injury","2024-06-01",{"date":86,"type":87},"2024-06-04","ACTUAL",{"date":89,"type":87},"2024-03-01",{"date":91,"type":72},"2024-12-31",{"name":58,"class":6},1]