[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616312":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":26,"collaborators":11,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":33,"acronym":11,"eligibilityCriteria":34,"healthyVolunteers":35,"sex":36,"minAge":37,"maxAge":38,"enrollmentInfo":39,"targetDuration":11,"studyType":42,"phases":43,"briefSummary":45,"conditions":46,"keywords":51,"overallStatus":57,"whyStopped":11,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":11},{"fullName":5,"class":6},"Shanghai Zhongshan Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Single Group - Self-Controlled","EXPERIMENTAL",null,[13,14],"Procedure: Electrical Impedance Tomography Saline Indicator Procedure","Device: Electrical Impedance Tomography Device",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":11},"PROCEDURE","Electrical Impedance Tomography Saline Indicator Procedure","Participants undergo continuous electrical impedance tomography (EIT) monitoring with a circumferential electrode belt placed around the thorax. During the procedure, participants perform standardized inspiratory and expiratory breath-hold maneuvers. At each breath-hold phase, a rapid intravenous bolus of sterile saline (10-20 mL) is administered, followed by a saline flush, to generate transient impedance changes for lung perfusion imaging using the saline indicator technique. EIT data are recorded continuously before, during, and after each saline injection. Each participant undergoes both breath-hold conditions and serves as their own control.",[9],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":11},"DEVICE","Electrical Impedance Tomography Device","An FDA-cleared electrical impedance tomography (EIT) device is used to noninvasively monitor thoracic impedance changes during the study procedures. The device is used solely for physiological monitoring and image acquisition and is not being evaluated for safety, performance, or a new indication.",[9],{"type":27,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100616312","effects-of-inspiratory-vs-expiratory-breath-hold-on-lung-perfusion-measured-by-eit-saline-indicator-method-a-self-controlled-study-100616312",false,"NCT07303972","Effects of Inspiratory vs Expiratory Breath-Hold on Lung Perfusion Measured by EIT Saline Indicator Method: A Self-Controlled Study","Electrical Impedance Tomography Saline Indicator Technique for Assessing Differences in Lung Perfusion Between Inspiratory and Expiratory Breath-Hold Phases: A Prospective Self-Controlled Study","Inclusion Criteria:\n\n* Age 18 to 65 years\n* Able to provide written informed consent\n* Able to perform standardized inspiratory and expiratory breath-hold maneuvers for at least 8 seconds\n* No known acute cardiopulmonary disease\n* Suitable for noninvasive electrical impedance tomography monitoring and intravenous saline administration\n\nExclusion Criteria:\n\n* Known severe cardiopulmonary disease (e.g., advanced chronic obstructive pulmonary disease, severe pulmonary hypertension, or heart failure)\n* Hemodynamic instability or clinically significant cardiac arrhythmia\n* Contraindication to intravenous saline administration or fluid bolus\n* Pregnancy or breastfeeding\n* Skin conditions or chest wall abnormalities preventing proper placement of EIT electrodes",true,"ALL","18 Years","65 Years",{"count":40,"type":41},100,"ESTIMATED","INTERVENTIONAL",[44],"NA","This study aims to compare lung perfusion distribution between inspiratory breath-hold and expiratory breath-hold phases using the saline indicator method combined with electrical impedance tomography (EIT). A self-controlled crossover design will be used in which each participant undergoes both breath-hold conditions with standardized rapid intravenous saline injections. The primary objective is to evaluate changes in global and regional pulmonary perfusion under different lung volume states. The findings may improve understanding of perfusion redistribution with lung inflation and support optimized ventilatory strategies in clinical practice.",[47,48,49,50],"Lung Perfusion","Respiratory Physiology","Electrical Impedance Tomography","Ventilation-Perfusion Mismatch",[49,47,52,53,54,55,56],"Saline Indicator","Breath-Hold","Inspiratory \u002F Expiratory Phases","Regional Perfusion","Ventilation-Perfusion Matching","NOT_YET_RECRUITING","2025-12-23",{"date":60,"type":61},"2025-12-26","ACTUAL",{"date":63,"type":41},"2026-01-01",{"date":65,"type":41},"2028-01-01",{"name":5,"class":6}]