[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645063":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":28,"locations":37,"responsibleParty":57,"collaborators":28,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":28,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":28,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":85,"whyStopped":28,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Federal University of Vicosa","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"1-Minute Inter-set Rest Interval","EXPERIMENTAL","Participants allocated to this group will perform a single lower-limb flywheel resistance exercise session using a 1-minute inter-set rest interval. The session will include squat, Romanian deadlift, knee extension, and knee flexion exercises.",[13],"Behavioral: Flywheel resistance exercise with 1-minute inter-set rest",{"label":15,"type":10,"description":11,"interventionNames":16},"2-Minute Inter-set Rest Interval",[17],"Behavioral: Flywheel resistance exercise with 2-minute inter-set rest",{"label":19,"type":10,"description":11,"interventionNames":20},"3-Minute Inter-set Rest Interval",[21],"Behavioral: Flywheel resistance exercise with 3-minute inter-set rest",[23,29,33],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"BEHAVIORAL","Flywheel resistance exercise with 1-minute inter-set rest","Participants will perform a single lower-limb flywheel resistance exercise session using a 1-minute inter-set rest interval. The session will include squat, Romanian deadlift, knee extension, and knee flexion exercises. Each exercise will be performed for 4 sets of 2 preparatory repetitions followed by 8 valid repetitions, using the same flywheel inertia, exercise order, and execution instructions across all groups. Participants will be instructed to perform the concentric phase as fast as possible and to brake the eccentric phase during the final portion of the movement. The interval between exercises will be standardized at 3 minutes.",[9],null,{"type":24,"name":30,"description":31,"armGroupLabels":32,"otherNames":28},"Flywheel resistance exercise with 2-minute inter-set rest","Participants will perform a single lower-limb flywheel resistance exercise session using a 2-minute inter-set rest interval. The session will include squat, Romanian deadlift, knee extension, and knee flexion exercises. Each exercise will be performed for 4 sets of 2 preparatory repetitions followed by 8 valid repetitions, using the same flywheel inertia, exercise order, and execution instructions across all groups. Participants will be instructed to perform the concentric phase as fast as possible and to brake the eccentric phase during the final portion of the movement. The interval between exercises will be standardized at 3 minutes.",[15],{"type":24,"name":34,"description":35,"armGroupLabels":36,"otherNames":28},"Flywheel resistance exercise with 3-minute inter-set rest","Participants will perform a single lower-limb flywheel resistance exercise session using a 3-minute inter-set rest interval. The session will include squat, Romanian deadlift, knee extension, and knee flexion exercises. Each exercise will be performed for 4 sets of 2 preparatory repetitions followed by 8 valid repetitions, using the same flywheel inertia, exercise order, and execution instructions across all groups. Participants will be instructed to perform the concentric phase as fast as possible and to brake the eccentric phase during the final portion of the movement. The interval between exercises will be standardized at 3 minutes.",[19],[38],{"facility":39,"status":28,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Federal University of Viçosa","Viçosa","Minas Gerais","36570-900","Brazil","BR",{"type":46,"coordinates":47},"Point",[48,49],-42.88194,-20.75389,{"lat":49,"lon":48},[52],{"name":53,"role":54,"phone":55,"phoneExt":28,"email":56},"Study Coordinator","CONTACT","(31) 98359-5541","wanderson.machado@ufv.br",{"type":58,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR","100645063","effects-of-inter-set-rest-intervals-on-muscle-damage-after-flywheel-exercise-in-untrained-men-rct-100645063",false,"NCT07679971","Effects of Inter-Set Rest Intervals on Muscle Damage After Flywheel Exercise in Untrained Men (RCT)","Effects of Different Inter-Set Rest Intervals on Indirect Markers of Muscle Damage and Mechanical Parameters After Flywheel Resistance Training in Untrained Men: A Randomized Parallel-Group Clinical Trial","Inclusion Criteria:\n\n* Age between 18 and 40 years;\n* Apparently healthy and clinically able to perform physical exercise;\n* No participation in structured resistance training during the previous 6 months;\n* Agreement to comply with all study visits and procedures;\n* Signed informed consent form.\n\nExclusion Criteria:\n\n* History of lower-limb musculoskeletal injury or surgery that may impair performance or safety during the proposed exercise protocol;\n* Current pain, injury, or functional limitation in the lower limbs;\n* Use of ergogenic aids that may affect physical performance or muscle recovery;\n* Use of analgesic or anti-inflammatory medication during the study period;\n* Failure to attend the scheduled visits required for the primary outcome assessment.",true,"MALE","18 Years","40 Years",{"count":71,"type":72},30,"ESTIMATED","INTERVENTIONAL",[75],"NA","This randomized parallel-group clinical trial will compare the acute effects of three different inter-set rest intervals during a single lower-limb flywheel resistance exercise session in untrained men. Participants will be randomly allocated to one of three groups: 1-minute, 2-minute, or 3-minute inter-set rest interval. The primary outcome will be the change in maximal voluntary isometric contraction of the knee extensors 48 hours after exercise. Secondary outcomes will include mechanical variables during the exercise session, countermovement jump performance, knee flexor maximal voluntary isometric contraction, muscle soreness, pressure pain threshold, range of motion, ultrasound-derived muscle thickness and echo intensity, perceived exertion, perceived discomfort, perceived recovery status, creatine kinase, and lactate dehydrogenase.",[78],"Exercise-induced Muscle Damage",[80,81,82,83,84],"Flywheel exercise","Resistance training","Muscle damage","Maximal voluntary isometric contraction","Untrained men","NOT_YET_RECRUITING","2026-06-25",{"date":88,"type":89},"2026-07-01","ACTUAL",{"date":91,"type":72},"2026-06",{"date":93,"type":72},"2026-07",{"name":5,"class":6},1]