[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535786":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":27,"centralContacts":31,"locations":40,"responsibleParty":478,"collaborators":481,"id":484,"slug":485,"hasResults":486,"nctId":487,"briefTitle":488,"officialTitle":489,"acronym":23,"eligibilityCriteria":490,"healthyVolunteers":486,"sex":491,"minAge":492,"maxAge":23,"enrollmentInfo":493,"targetDuration":23,"studyType":496,"phases":497,"briefSummary":499,"conditions":500,"keywords":506,"overallStatus":61,"whyStopped":23,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":516,"completionDateStruct":518,"leadSponsor":520,"locationsCount":521},{"fullName":5,"class":6},"Peking University First Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Routine thermal management","PLACEBO_COMPARATOR","Patients assigned to routine thermal management will not be pre-warmed and ambient intraoperative temperature will be maintained near 20°C per routine. Only transfused blood will be warmed. An upper- or lower-body forced-air cover will be positioned over an appropriate non-operative site but will not initially be activated. Should core temperature decrease to 35.5°C, the warmer will be activated as necessary to prevent core temperature from decreasing further. The target nasopharyngeal temperature is 35.5°C.",[13],"Other: Routine thermal management",{"label":15,"type":16,"description":17,"interventionNames":18},"Target temperature management","EXPERIMENTAL","Pre-warming is performed with a full-body forced-air cover and electrically heated blanket for about 30 minutes before induction of anesthesia. The warmer will initially be set to \"high\" which corresponds to about 43°C. It will be subsequently adjusted to make patients feel warm, but not uncomfortably so. Patients will be warmed during surgery using two forced-air covers or combining forced-air covers with electric heating blanket when clinically practical. All intravenous fluids will be warmed to body temperature. There is no need to control ambient temperature since ambient temperature has little effect on core temperature in patients warmed with forced air. The target nasopharyngeal temperature is 36.8°C.",[19],"Other: Target temperature management",[21,24],{"type":6,"name":9,"description":11,"armGroupLabels":22,"otherNames":23},[9],null,{"type":6,"name":15,"description":25,"armGroupLabels":26,"otherNames":23},"Pre-warming is performed with a full-body forced-air cover and electrically heated blanket for about 30 minutes before induction of anesthesia. The warmer will initially be set to \"high\" which corresponds to about 43°C. It will be subsequently adjusted to make patients feel warm, but not uncomfortably so. Patients will be warmed during surgery using two forced-air covers or combining forced-air covers with electric heating blanket when clinically practical. All intravenous fluids will be warmed to body temperature. There is no need to control ambient temperature since ambient temperature has little effect on core temperature in patients warmed with forced air. The target nasopharyngeal temperature is 36.8℃.",[15],[28],{"name":29,"affiliation":5,"role":30},"Dong-Xin Wang, MD, PhD","PRINCIPAL_INVESTIGATOR",[32,36],{"name":29,"role":33,"phone":34,"phoneExt":23,"email":35},"CONTACT","8610 83572784","wangdongxin@hotmail.com",{"name":37,"role":33,"phone":38,"phoneExt":23,"email":39},"Xin-quan Liang, MD","+8615210846532","liangxinquan09@163.com",[41,59,73,83,95,110,120,130,141,152,161,170,179,188,197,206,215,229,244,258,272,287,297,310,324,336,350,362,376,391,406,420,435,446,457,466],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"The People's Hospital of Chizhou","NOT_YET_RECRUITING","Chizhou","Anhui","247099","China","CN",{"type":50,"coordinates":51},"Point",[52,53],117.47783,30.66134,{"lat":53,"lon":52},[56],{"name":57,"role":33,"phone":58,"phoneExt":23,"email":23},"Ming-sheng Bao","+86 15339668345",{"facility":60,"status":61,"city":62,"state":45,"zip":63,"country":47,"countryCode":48,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"The Second Affiliated Hospital of Anhui Medical University","RECRUITING","Hefei","230601",{"type":50,"coordinates":65},[66,67],117.28083,31.86389,{"lat":67,"lon":66},[70],{"name":71,"role":33,"phone":23,"phoneExt":23,"email":72},"Ye Zhang, MD","zhangye_hassan@sina.com",{"facility":74,"status":61,"city":62,"state":45,"zip":75,"country":47,"countryCode":48,"cosmosGeoPoint":76,"geoPoint":78,"contacts":79},"The First Affiliated Hospital of Anhui Medical University","610042",{"type":50,"coordinates":77},[66,67],{"lat":67,"lon":66},[80],{"name":81,"role":33,"phone":82,"phoneExt":23,"email":23},"Xuesheng Liu","+86 18655193385",{"facility":84,"status":61,"city":85,"state":45,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Maanshan People's 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15210846532","xq_liang@foxmail.com",{"facility":121,"status":61,"city":97,"state":98,"zip":122,"country":47,"countryCode":48,"cosmosGeoPoint":123,"geoPoint":125,"contacts":126},"Guang'anmen Hospital China Academy of Chinese Medical Sciences","100055",{"type":50,"coordinates":124},[102,103],{"lat":103,"lon":102},[127],{"name":128,"role":33,"phone":129,"phoneExt":23,"email":23},"Xi-chen Dong","+86 13810248772",{"facility":131,"status":61,"city":97,"state":98,"zip":132,"country":47,"countryCode":48,"cosmosGeoPoint":133,"geoPoint":135,"contacts":136},"Xiyuan Hospital of China Academy of Chinese Medical Sciences","100091",{"type":50,"coordinates":134},[102,103],{"lat":103,"lon":102},[137],{"name":138,"role":33,"phone":139,"phoneExt":23,"email":140},"Xiu-mei Gao","+86 13810208575","2592153818@qq.com",{"facility":142,"status":61,"city":97,"state":98,"zip":143,"country":47,"countryCode":48,"cosmosGeoPoint":144,"geoPoint":146,"contacts":147},"Peking Union Medical College Hospital","100730",{"type":50,"coordinates":145},[102,103],{"lat":103,"lon":102},[148],{"name":149,"role":33,"phone":150,"phoneExt":23,"email":151},"Li-jian Pei","8610-65296114","hazelbeijing@vip.163.com",{"facility":153,"status":61,"city":97,"state":98,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":154,"geoPoint":156,"contacts":157},"Aerospace Medical Center",{"type":50,"coordinates":155},[102,103],{"lat":103,"lon":102},[158],{"name":159,"role":33,"phone":160,"phoneExt":23,"email":23},"Zhanmin Yang","86 18610197799",{"facility":162,"status":43,"city":97,"state":98,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":163,"geoPoint":165,"contacts":166},"Beijing Chao-Yang Hospital, Capital Medical University",{"type":50,"coordinates":164},[102,103],{"lat":103,"lon":102},[167],{"name":168,"role":33,"phone":169,"phoneExt":23,"email":23},"Changwei Wei, M.D.","86 13810678936",{"facility":171,"status":43,"city":97,"state":98,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":172,"geoPoint":174,"contacts":175},"Beijing Chuiyangliu Hospital",{"type":50,"coordinates":173},[102,103],{"lat":103,"lon":102},[176],{"name":177,"role":33,"phone":178,"phoneExt":23,"email":23},"Yanwei Yang","86 18612596817",{"facility":180,"status":43,"city":97,"state":98,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":181,"geoPoint":183,"contacts":184},"Beijing Coal Group General Hospital",{"type":50,"coordinates":182},[102,103],{"lat":103,"lon":102},[185],{"name":186,"role":33,"phone":187,"phoneExt":23,"email":23},"Yonggang Li","86 13241867130",{"facility":189,"status":61,"city":97,"state":98,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":190,"geoPoint":192,"contacts":193},"Beijing Electric Power Hospital",{"type":50,"coordinates":191},[102,103],{"lat":103,"lon":102},[194],{"name":195,"role":33,"phone":196,"phoneExt":23,"email":23},"Wenyong Han","86 13671003131",{"facility":198,"status":43,"city":97,"state":98,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":199,"geoPoint":201,"contacts":202},"Peking University International Hospital",{"type":50,"coordinates":200},[102,103],{"lat":103,"lon":102},[203],{"name":204,"role":33,"phone":205,"phoneExt":23,"email":23},"Kunpeng Liu, M.D.","+8613681446866",{"facility":207,"status":43,"city":97,"state":98,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":208,"geoPoint":210,"contacts":211},"The First Hospital of Tsinghua University",{"type":50,"coordinates":209},[102,103],{"lat":103,"lon":102},[212],{"name":213,"role":33,"phone":214,"phoneExt":23,"email":23},"Duomao Lin","86 13811495413",{"facility":216,"status":61,"city":217,"state":218,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"The First Affiliated Hospital of Chongqing Medical University","Chongqing","Chongqing Municipality",{"type":50,"coordinates":220},[221,222],106.55771,29.56026,{"lat":222,"lon":221},[225],{"name":226,"role":33,"phone":227,"phoneExt":23,"email":228},"Su Min","+86 13508302749","ms89011068@163.com",{"facility":230,"status":61,"city":231,"state":232,"zip":233,"country":47,"countryCode":48,"cosmosGeoPoint":234,"geoPoint":238,"contacts":239},"Peking University Shenzhen Hospital","Shenzhen","Guangdong","518034",{"type":50,"coordinates":235},[236,237],114.0683,22.54554,{"lat":237,"lon":236},[240],{"name":241,"role":33,"phone":242,"phoneExt":23,"email":243},"Tao Luo","+86 13510820779","496855048@qq.com",{"facility":245,"status":43,"city":246,"state":247,"zip":248,"country":47,"countryCode":48,"cosmosGeoPoint":249,"geoPoint":253,"contacts":254},"The Fourth Hospital of Hebei Medical University (Hebei Tumor Hospital)","Shijiazhuang","Hebei","050011",{"type":50,"coordinates":250},[251,252],114.47861,38.04139,{"lat":252,"lon":251},[255],{"name":256,"role":33,"phone":23,"phoneExt":23,"email":257},"Chao Li","jysylc@163.com",{"facility":259,"status":61,"city":260,"state":261,"zip":262,"country":47,"countryCode":48,"cosmosGeoPoint":263,"geoPoint":267,"contacts":268},"First Affiliated Hospital of Harbin Medical University","Harbin","Heilongjiang","163711",{"type":50,"coordinates":264},[265,266],126.65,45.75,{"lat":266,"lon":265},[269],{"name":270,"role":33,"phone":23,"phoneExt":23,"email":271},"Kun Wang, MD","hydwangkun@sina.com",{"facility":273,"status":61,"city":274,"state":275,"zip":276,"country":47,"countryCode":48,"cosmosGeoPoint":277,"geoPoint":281,"contacts":282},"The First Affiliated Hospital of Zhengzhou University","Zhengzhou","Henan","450052",{"type":50,"coordinates":278},[279,280],113.64861,34.75778,{"lat":280,"lon":279},[283],{"name":284,"role":33,"phone":285,"phoneExt":23,"email":286},"Jian-Jun Yang","+86 13357739238","yjyangjj@126.com",{"facility":288,"status":43,"city":274,"state":275,"zip":289,"country":47,"countryCode":48,"cosmosGeoPoint":290,"geoPoint":292,"contacts":293},"Henan Provincial People's Hospital","463599",{"type":50,"coordinates":291},[279,280],{"lat":280,"lon":279},[294],{"name":295,"role":33,"phone":296,"phoneExt":23,"email":23},"Jia-qiang Yang","+86 13937121360",{"facility":298,"status":43,"city":299,"state":300,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":301,"geoPoint":305,"contacts":306},"Jingzhou Central Hospital","Jingzhou","Hubei",{"type":50,"coordinates":302},[303,304],112.19028,30.35028,{"lat":304,"lon":303},[307],{"name":308,"role":33,"phone":309,"phoneExt":23,"email":23},"Kun Zhang","86 18107168484",{"facility":311,"status":61,"city":312,"state":313,"zip":314,"country":47,"countryCode":48,"cosmosGeoPoint":315,"geoPoint":319,"contacts":320},"Jiangyin People's Hospital","Jiangyin","Jiangsu","214400",{"type":50,"coordinates":316},[317,318],120.26302,31.91102,{"lat":318,"lon":317},[321],{"name":322,"role":33,"phone":323,"phoneExt":23,"email":23},"Jian-qing Chen","+86 18921233188",{"facility":325,"status":43,"city":326,"state":313,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":327,"geoPoint":331,"contacts":332},"The First Affiliated Hospital of Kangda College of Nanjing Medical University ( Lianyungang First People's Hospital)","Lianyungang",{"type":50,"coordinates":328},[329,330],119.21556,34.59845,{"lat":330,"lon":329},[333],{"name":334,"role":33,"phone":335,"phoneExt":23,"email":23},"Yong Wu","86 18961325621",{"facility":337,"status":61,"city":338,"state":313,"zip":339,"country":47,"countryCode":48,"cosmosGeoPoint":340,"geoPoint":344,"contacts":345},"Jiangsu Province Hospital","Nanjing","210029",{"type":50,"coordinates":341},[342,343],118.77778,32.06167,{"lat":343,"lon":342},[346],{"name":347,"role":33,"phone":348,"phoneExt":23,"email":349},"Cun-ming Liu","+86 13951890866","cunmingliu@njmu.edu.cn",{"facility":351,"status":43,"city":352,"state":313,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":353,"geoPoint":357,"contacts":358},"The Second Affiliated Hospital of Soochow University","Suzhou",{"type":50,"coordinates":354},[355,356],120.59538,31.30408,{"lat":356,"lon":355},[359],{"name":360,"role":33,"phone":361,"phoneExt":23,"email":23},"Jiang Zhu","86 13962153438",{"facility":363,"status":43,"city":364,"state":313,"zip":365,"country":47,"countryCode":48,"cosmosGeoPoint":366,"geoPoint":370,"contacts":371},"The People's Hospital of Wuxi","Wuxi","214023",{"type":50,"coordinates":367},[368,369],120.28857,31.56887,{"lat":369,"lon":368},[372],{"name":373,"role":33,"phone":374,"phoneExt":23,"email":375},"Xin Zhang","+86 13818832760","xinzhang3@njmu.edu.cn",{"facility":377,"status":61,"city":378,"state":379,"zip":380,"country":47,"countryCode":48,"cosmosGeoPoint":381,"geoPoint":385,"contacts":386},"Xijing Hospital, Fourth Military Medical University","Xi'an","Shaanxi","710032",{"type":50,"coordinates":382},[383,384],108.92861,34.25833,{"lat":384,"lon":383},[387],{"name":388,"role":33,"phone":389,"phoneExt":23,"email":390},"Zhi-Hong Lu, MD","+86 13891975018","deerlu23@163.com",{"facility":392,"status":43,"city":393,"state":394,"zip":395,"country":47,"countryCode":48,"cosmosGeoPoint":396,"geoPoint":400,"contacts":401},"The First Affiliated Hospital of Shandong First Medical University","Jinan","Shandong","250013",{"type":50,"coordinates":397},[398,399],116.99722,36.66833,{"lat":399,"lon":398},[402],{"name":403,"role":33,"phone":404,"phoneExt":23,"email":405},"Jian-bo Wu","+86 13805319310","jianbowu@sdu.edu.cn",{"facility":407,"status":61,"city":408,"state":394,"zip":409,"country":47,"countryCode":48,"cosmosGeoPoint":410,"geoPoint":414,"contacts":415},"The People's Hospital of Liaocheng","Liaocheng","252000",{"type":50,"coordinates":411},[412,413],116.00247,36.45064,{"lat":413,"lon":412},[416],{"name":417,"role":33,"phone":418,"phoneExt":23,"email":419},"Chong-wang Zhang","+86 13346256809","zwzhang68@sina.com",{"facility":421,"status":61,"city":422,"state":423,"zip":424,"country":47,"countryCode":48,"cosmosGeoPoint":425,"geoPoint":429,"contacts":430},"Chengdu Seventh People's Hospital","Chengdu","Sichuan","610041",{"type":50,"coordinates":426},[427,428],104.06667,30.66667,{"lat":428,"lon":427},[431],{"name":432,"role":33,"phone":433,"phoneExt":23,"email":434},"Hui Zhong","+86 18280318565","qyymzsszx@163.com",{"facility":436,"status":61,"city":422,"state":423,"zip":437,"country":47,"countryCode":48,"cosmosGeoPoint":438,"geoPoint":440,"contacts":441},"Sichuan Provincial People's Hospital","610072",{"type":50,"coordinates":439},[427,428],{"lat":428,"lon":427},[442],{"name":443,"role":33,"phone":444,"phoneExt":23,"email":445},"Qian Lei","+86 17744339891","leiqianggh@163.com",{"facility":447,"status":61,"city":422,"state":423,"zip":448,"country":47,"countryCode":48,"cosmosGeoPoint":449,"geoPoint":451,"contacts":452},"The First Affiliated Hospital of Chengdu Medical College","610500",{"type":50,"coordinates":450},[427,428],{"lat":428,"lon":427},[453],{"name":454,"role":33,"phone":455,"phoneExt":23,"email":456},"Ping-liang Yang","+86 18140064602","pingliangyang@163.com",{"facility":458,"status":43,"city":422,"state":423,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":459,"geoPoint":461,"contacts":462},"The Second People's Hospital of Yibin (affiliated with West China Hospital of Sichuan University)",{"type":50,"coordinates":460},[427,428],{"lat":428,"lon":427},[463],{"name":464,"role":33,"phone":465,"phoneExt":23,"email":23},"Jinghua Ren, M.D.","8613568084991",{"facility":467,"status":61,"city":468,"state":423,"zip":23,"country":47,"countryCode":48,"cosmosGeoPoint":469,"geoPoint":473,"contacts":474},"Deyang People's Hospital","Deyang",{"type":50,"coordinates":470},[471,472],104.38198,31.13019,{"lat":472,"lon":471},[475],{"name":476,"role":33,"phone":477,"phoneExt":23,"email":23},"Xianjie Zhang, M.D.","86 13981088319",{"type":30,"investigatorFullName":479,"investigatorTitle":480,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Dong-Xin Wang","Professor and Chairman, Department of Anesthesiology",[482],{"name":483,"class":6},"Peking University","100535786","effects-of-intraoperative-targeted-temperature-management-on-incidence-of-postoperative-delirium-and-long-term-survival-100535786",false,"NCT06256354","Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival","Effects of Intraoperative Targeted Temperature Management on Incidence of Postoperative Delirium and Long-term Survival in Older Patients Having Major Cancer Surgery: A Multicenter Randomized Trial","Inclusion Criteria:\n\n1. Age ≥65 years.\n2. Planned potentially curative initial cancer surgery with an expected duration of 2 hours or longer under general anesthesia.\n\nExclusion Criteria:\n\n1. Preoperative fever (tympanic temperature ≥38℃).\n2. Known or suspected preoperative infection.\n3. Previous history of schizophrenia, epilepsy, Parkinson disease, myasthenia gravis, or delirium.\n4. Unable to communicate due to severe dementia, language barrier, or coma.\n5. Critically ill (Left ventricular ejection fraction \\\u003C30%, Child-Pugh grades C, requirement of renal replacement therapy, American Society of Anesthesiologists physical status\\>IV, or expected survival \\\u003C24 hours).\n6. Scheduled surgery for breast cancer, intracranial tumors, or rare cancers.\n7. Planned to undergo therapeutic hypothermia.\n8. Body mass index \\>30 kg\u002Fm2 (to facilitate thermal management).\n9. Have participated in this study previously.\n10. Any other conditions that are considered unsuitable for study participation.","ALL","65 Years",{"count":494,"type":495},3992,"ESTIMATED","INTERVENTIONAL",[498],"NA","Intraoperative hypothermia is common in patients having major surgery and the compliance with intraoperative temperature monitoring and management remains poor. Studies suggest that intraoperative hypothermia is an important risk factor of postoperative delirium, which is associated with worse early and long-term outcomes. Furthermore, perioperative hypothermia increases stress responses and provokes immune suppression, which might promote cancer recurrence and metastasis. In a recent trial, targeted temperature management reduced intraoperative hypothermia and emergence delirium. There was also a trend of reduced postoperative delirium, although not statistically significant. This trial is designed to test the hypothesis that intraoperative targeted temperature management may reduce postoperative delirium and improves progression-free survival in older patients recovering from major cancer surgery.",[501,502,503,504,505],"Cancer Surgery","Intraoperative Hypothermia","Targeted Temperature Management","Postoperative Delirium","Long-term Survivors",[507,508,509,510,511],"Cancer surgery","Intraoperative hypothermia","Targeted temperature management","Postoperative delirium","Long-term survival","2026-06-18",{"date":514,"type":515},"2026-06-23","ACTUAL",{"date":517,"type":515},"2024-05-29",{"date":519,"type":495},"2032-06",{"name":5,"class":6},36]