[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636187":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":35,"centralContacts":40,"locations":46,"responsibleParty":66,"collaborators":35,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":35,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":98,"whyStopped":35,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Firat University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Isometric Exercise Group","EXPERIMENTAL","Participants in this group will receive a standardized physiotherapy program (hot pack, TENS, and therapeutic ultrasound) followed by isometric VMO strengthening exercises performed in the terminal knee extension range (0-30°). Exercises will be performed 3 sets of 10 repetitions, with 10-second contractions, three times per week for 8 weeks.",[13],"Other: Isometric VMO Exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"Isotonic Exercise Group","Participants will receive the same standardized physiotherapy program followed by isotonic (concentric and eccentric) VMO strengthening exercises performed within the 0-30° knee extension range using external resistance. Exercises will be performed 3 sets of 10-15 repetitions, three times per week for 8 weeks.",[18],"Other: Isotonic VMO Exercise",{"label":20,"type":10,"description":21,"interventionNames":22},"Eccentric Exercise Group","Participants will receive the same standardized physiotherapy program followed by eccentric VMO strengthening exercises performed within the 0-30° knee extension range. Exercises will be performed 3 sets of 10-15 repetitions, three times per week for 8 weeks.",[23],"Other: Eccentric VMO Exercise",[25,31,36],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"Isometric VMO Exercise","Isometric contractions of the vastus medialis oblique muscle will be performed with the knee supported at approximately 15° flexion, emphasizing maximal voluntary contraction without joint movement.",[9],[30],"Experimental: Isometric Exercise Group",{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Isotonic VMO Exercise","Participants will perform controlled concentric and eccentric contractions using ankle weights through a limited range of motion (0-30° knee extension).",[15],null,{"type":6,"name":37,"description":38,"armGroupLabels":39,"otherNames":35},"Eccentric VMO Exercise","Participants will perform eccentric contractions against resistance during knee flexion, with assisted concentric return to the starting position.",[20],[41],{"name":42,"role":43,"phone":44,"phoneExt":35,"email":45},"Muharrem Gökhan Beydağı, PhD","CONTACT","+905323581105","mgbeydagi@firat.edu.tr",[47],{"facility":5,"status":35,"city":48,"state":49,"zip":50,"country":51,"countryCode":35,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Elâzığ","MErkez","23200","Turkey (Türkiye)",{"type":53,"coordinates":54},"Point",[55,56],39.22321,38.67431,{"lat":56,"lon":55},[59,63],{"name":60,"role":43,"phone":61,"phoneExt":35,"email":62},"Muharrem Beydağı, PhD","05323581105","fztgokhan@hotmail.com",{"name":64,"role":65,"phone":35,"phoneExt":35,"email":35},"Muhammet Şahin Elbastı, PhD","PRINCIPAL_INVESTIGATOR",{"type":65,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"Muharrem Gökhan Beydağı","Assistant Professor and Principal Investigator","100636187","effects-of-isometric-isotonic-and-eccentric-vmo-exercises-in-patellofemoral-pain-syndrome-100636187",false,"NCT07562425","Effects of Isometric, Isotonic, and Eccentric VMO Exercises in Patellofemoral Pain Syndrome","Comparison of the Effects of Isometric, Isotonic, and Eccentric Vastus Medialis Oblique Strengthening Exercises Applied in Terminal Knee Extension Range on Pain, Function, and Muscle Architecture in Individuals With Patellofemoral Pain Syndrome: A Randomized Controlled Trial","VMO-PFPS","Inclusion Criteria:\n\n* Aged between 18 and 40 years\n* Clinically diagnosed with patellofemoral pain syndrome\n* Presence of anterior knee pain for at least 3 months\n* Pain during activities such as stair climbing, squatting, running, or prolonged sitting\n* Pain intensity of at least 3\u002F10 on the Visual Analog Scale (VAS)\n* Willingness to participate and provide written informed consent\n\nExclusion Criteria:\n\n* History of knee trauma or surgery\n* Meniscal injury, ligament injury, or knee instability\n* Advanced osteoarthritis\n* Neurological disorders\n* Rheumatologic diseases\n* Participation in a structured knee rehabilitation program within the last 6 months\n* Pregnancy","ALL","18 Years","50 Years",{"count":81,"type":82},90,"ESTIMATED","INTERVENTIONAL",[85],"NA","Patellofemoral pain syndrome (PFPS) is a common musculoskeletal condition characterized by anterior knee pain, especially during activities such as stair climbing, squatting, running, and prolonged sitting. Weakness or delayed activation of the vastus medialis oblique (VMO) muscle is considered an important contributing factor in the development of PFPS.\n\nThis study aims to compare the effects of three different types of VMO strengthening exercises (isometric, isotonic, and eccentric) applied within the terminal knee extension range (0-30°) on pain, functional performance, and muscle architecture in individuals with PFPS.\n\nParticipants will be randomly assigned to one of three exercise groups. All participants will receive a standardized physiotherapy program, including heat therapy, TENS, and therapeutic ultrasound, followed by group-specific VMO strengthening exercises. The intervention will be performed three times per week for 8 weeks.\n\nOutcomes will be assessed before and after the intervention and will include pain intensity (Visual Analog Scale), functional performance (WOMAC, 30-second sit-to-stand test, and stair test), and muscle architecture parameters measured by ultrasound imaging.\n\nThe results of this study are expected to provide evidence for optimizing rehabilitation strategies in individuals with PFPS.",[88,89],"Patellofemoral Pain Syndrome","Anterior Knee Pain",[91,92,93,94,95,96,97],"Vastus Medialis Oblique","Knee Pain","Exercise Therapy","Isometric Exercise","Isotonic Exercise","Eccentric Exercise","Muscle Architecture","NOT_YET_RECRUITING","2026-05-07",{"date":101,"type":102},"2026-05-12","ACTUAL",{"date":104,"type":82},"2026-05-20",{"date":106,"type":82},"2026-08",{"name":5,"class":6},1]