[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616725":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":30,"responsibleParty":47,"collaborators":49,"id":52,"slug":20,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":20,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":20,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Uşak University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Isotretinoin Treatment Group","EXPERIMENTAL","Participants in this arm will receive standard-of-care oral isotretinoin prescribed by the Dermatology Department for the treatment of acne vulgaris. The dosage and duration of isotretinoin therapy will follow routine clinical practice and will be determined by the treating dermatologist. Olfactory function and nasal symptom assessments will be performed before starting isotretinoin and after at least four weeks of treatment.",[13],"Drug: isotretinoin",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","isotretinoin","Oral isotretinoin prescribed as standard-of-care treatment for acne vulgaris. The dosage, formulation, and duration of therapy will follow routine clinical practice and will be determined by the treating dermatologist based on the participant's clinical condition and body weight. Participants will typically receive daily oral isotretinoin for at least four weeks before the post-treatment assessments.",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Faruk Kadri Bakkal, MD, Asistant Professor","CONTACT","+905059242255","faruk.bakkal@usak.edu.tr",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},"Neslihan Demirel Öğüt, MD, Associate Professor","neslihan.ogut@usak.edu.tr",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":20,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Uşak University Faculty of Medicine","RECRUITING","Uşak","Merkez","64300","Turkey (Türkiye)",{"type":39,"coordinates":40},"Point",[41,42],29.4058,38.67351,{"lat":42,"lon":41},[45],{"name":46,"role":24,"phone":25,"phoneExt":20,"email":26},"Faruk Kadri Bakkal",{"type":48,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[50],{"name":51,"class":6},"The Scientific and Technological Research Council of Turkey","100616725",false,"NCT07309341","Effects of Isotretinoin on Smell","Effects of Isotretinoin on Nasal Mucociliary Clearance and Olfactory Function","Inclusion Criteria:\n\n* Diagnosed with acne and scheduled to start oral isotretinoin as part of routine dermatology care\n* Willing to participate and able to give informed consent\n* Not currently smoking\n* No history of allergic rhinitis, sinusitis, or active upper respiratory infection\n* No medical condition known to affect the sense of smell\n\nExclusion Criteria:\n\n* Younger than 18 years or older than 45 years\n* Current cigarette smoking\n* History of chronic sinonasal disease\n* Any condition that would prevent completing the smell test\n* Not willing to continue participation or withdrawal of consent at any time","ALL","18 Years","45 Years",{"count":62,"type":63},54,"ESTIMATED","INTERVENTIONAL",[66],"NA","Isotretinoin is a common medicine used to treat moderate to severe acne. It often causes dryness of the skin and the inside of the nose. Because a normal sense of smell depends on a healthy nasal lining, this dryness may affect how well a person can smell.\n\nThis study will examine whether isotretinoin treatment changes the sense of smell in adults with acne. Before starting isotretinoin, participants will complete a standardized smell test and two short questionnaires about nasal symptoms and quality of life: the Nasal Obstruction Symptom Evaluation (NOSE) scale and the 22-item Sino-Nasal Outcome Test (SNOT-22). After at least 4 weeks of treatment, the same smell test and questionnaires will be repeated.\n\nBy comparing results before and after treatment, the study will test the hypothesis that isotretinoin has a negative effect on olfactory function and may reduce patients' ability to smell.",[69],"Smell Dysfunction",[71,72,17],"olfaction","smell disfunction","2026-06-29",{"date":75,"type":76},"2026-06-30","ACTUAL",{"date":78,"type":76},"2025-06-01",{"date":80,"type":63},"2026-08-01",{"name":5,"class":6},1]