[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100518034":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":55,"collaborators":57,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":23,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":40,"whyStopped":23,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"University of Arkansas","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High Quality Protein Intake - Lean Pork","ACTIVE_COMPARATOR","Meal patterns will mimic a standard American diet (50% carbohydrate, 15% protein, 35% fat), providing an isonitrogenous 0.8 g\u002Fkg\u002Fd protein, and meeting individual estimated daily energy requirements. We have chosen 0.8 g\u002Fkg\u002Fd as it is the recommend dietary allowance for protein in the US. This arm's protein source will be from lean pork.",[13],"Other: Lean Pork vs Plant-Based Protein",{"label":15,"type":10,"description":16,"interventionNames":17},"Low Quality Protein Intake - Plant-Based","Meal patterns will mimic a standard American diet (50% carbohydrate, 15% protein, 35% fat), providing an isonitrogenous 0.8 g\u002Fkg\u002Fd protein, and meeting individual estimated daily energy requirements. We have chosen 0.8 g\u002Fkg\u002Fd as it is the recommend dietary allowance for protein in the US. This arm's protein source will be from plant-based protein (ie impossible burger, black bean burger, soy, etc).",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Lean Pork vs Plant-Based Protein","Participants will eat prepared study meals for three days that have either protein sourced from lean pork or plant-based sources.",[9,15],null,[25],{"name":26,"affiliation":5,"role":27},"David Church, PhD","PRINCIPAL_INVESTIGATOR",[29,33],{"name":26,"role":30,"phone":31,"phoneExt":23,"email":32},"CONTACT","501-526-5769","dchurch@uams.edu",{"name":34,"role":30,"phone":35,"phoneExt":23,"email":36},"Amanda Gwin, PA-C","5018380096","algwin@uams.edu",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"University of Arkansas for Medical Sciences","RECRUITING","Little Rock","Arkansas","72205","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-92.28959,34.74648,{"lat":50,"lon":49},[53],{"name":54,"role":30,"phone":23,"phoneExt":23,"email":32},"David D Church, PhD",{"type":56,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[58],{"name":59,"class":6},"National Pork Board","100518034","effects-of-lean-pork-loin-intake-on-protein-homeostasis-and-glucose-regulation-in-prediabetic-adults-100518034",false,"NCT06025292","Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults","PORK","Inclusion Criteria:\n\n* 1\\. Males and females ages 40-65 years.\n* 2\\. BMI 25 to ≤40 kg\u002Fm2 (or body fat % ≥25% in males or ≥36% in females)\n* 3\\. Capable of providing informed consent.\n* 4\\. COVID-19 negative and\u002For asymptomatic.\n* 5\\. Willing to abstain from drinking alcohol or consuming marijuana and CBD products during the 4-day study meal period\n* 6\\. HbA1c: 5.7-6.4% or fasting glucose 100-125 mg\u002FdL\n\nExclusion Criteria:\n\n* 1\\. Participant who does not\u002Fwill not eat animal protein sources.\n* 2\\. Allergy to wheat, soy, or common ingredients in plant-based protein products.\n* 3\\. Body mass index \\\u003C25 kg\u002Fm2 or \\>40 kg\u002Fm2.\n* 4\\. Hemoglobin \\\u003C10g\u002FdL at screening.\n* 5\\. Platelets \\\u003C150,000\u002FuL at screening.\n* 6\\. History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment.\n* 7\\. History of gastrointestinal bypass\u002Freduction surgery.\n* 8\\. Pregnant or lactating individuals.\n* 9\\. History of a chronic inflammatory disease (e.g. Lupus, Crohn's disease)\n* 10\\. Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy.\n* 11\\. Currently using prescription blood thinning medications.\n* 12\\. Currently using corticosteroid medications (cortisone, hydrocortisone, prednisone, etc.).\n* 13\\. Unable or unwilling to suspend aspirin use for 7 days prior to Visit 3 and Visit 7.\n* 14\\. Unwilling to avoid using protein or amino-acid supplements during participation.\n* 15\\. Unwilling to fast overnight.\n* 16\\. Unwilling to avoid alcohol, marijuana and CBD products for the four study days.\n* 17\\. Participants on glucagon-like-peptide-1 receptor agonist (GLP-1-RA) medications for \\\u003C1 month or with less than one treatment dose (injection) every two weeks","ALL","40 Years","65 Years",{"count":71,"type":72},20,"ESTIMATED","INTERVENTIONAL",[75],"NA","We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.",[78,79],"Hyperglycaemia (Non Diabetic)","Prediabetes",[81,82,83,84],"Lean pork","Muscle Protein Synthesis","Protein","Plant-Based","2026-06-04",{"date":87,"type":88},"2026-06-08","ACTUAL",{"date":90,"type":88},"2024-09-11",{"date":92,"type":72},"2027-01-31",{"name":5,"class":6},1]