[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553839":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":21,"locations":10,"responsibleParty":27,"collaborators":10,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":10,"eligibilityCriteria":37,"healthyVolunteers":38,"sex":39,"minAge":40,"maxAge":41,"enrollmentInfo":42,"targetDuration":10,"studyType":45,"phases":10,"briefSummary":46,"conditions":47,"keywords":53,"overallStatus":57,"whyStopped":10,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":10},{"fullName":5,"class":6},"Assiut University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Distribution of studied patients by age in years.",null,"Adult patients suffering of epilepsy aged 18 to 60 years old",{"label":13,"type":10,"description":14,"interventionNames":10},"Distribution of studied patients by duration of levetiracetam administration in months","Adult patients suffering of epilepsy and receiving treatment of levetiracetam for at least 6 months",[16,19],{"name":17,"affiliation":5,"role":18},"Safa Abdel-Sattar, professor","STUDY_DIRECTOR",{"name":20,"affiliation":5,"role":18},"Rania Mohamed, professor",[22],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Mohammed Ha Mohammed Abdel-Rahman, MBBCh","CONTACT","+201069387249","mohamedhamoda321@gmail.com",{"type":28,"investigatorFullName":29,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Safaa AA Khaled","professor","100553839","effects-of-levetiracetam-monotherapy-on-various-hematological-parameters-in-adult-patients-suffering-of-epilepsy-100553839",false,"NCT06491303","Effects of Levetiracetam Monotherapy on Various Hematological Parameters in Adult Patients Suffering of Epilepsy","Study of Effects of Levetiracetam Monotherapy on Various Hematological Parameters in Adult Patients Suffering of Epilepsy","Inclusion Criteria: Adult Epileptic patients of both genders aged \\>18 years on mono-therapy of levetiracetam anti-epileptic drug treatment for at least six months.\n\nExclusion Criteria:\n\n1. Patients were on treatment for less than six months.\n2. Patients had other conditions besides epilepsy that could affect blood parameters.\n3. patients on treatment with other antiepileptic medications besides levetiracetam.",true,"ALL","18 Years","60 Years",{"count":43,"type":44},45,"ESTIMATED","OBSERVATIONAL","Low therapeutic index of established antiepileptic drugs (AEDs) coupled with better understanding of the pathophysiology of seizure has encouraged the development of several novel AEDs. The conventional antiepileptics like phenytoin, phenobarbitone, valproate and carbamazepine and newer antiepileptics like levetiracetam. are used for epilepsy. AEDs induce potentially toxic effects over a period of time which remains undetermined over very long time. Earlier studies in this regard, states uneven results about hematological (Hb%, blood cell count etc.) toxicity of AEDs.",[48,49,50,51,52],"Neutropenia","Thrombocytopenia","Aplastic Anemia","Anemia","Epilepsy",[54,55,56,52,48,49],"Levetiracetam","Hematological effects","antiepileptic drugs","NOT_YET_RECRUITING","2024-06-30",{"date":60,"type":61},"2024-07-09","ACTUAL",{"date":63,"type":44},"2024-11-01",{"date":65,"type":44},"2025-12-01",{"name":5,"class":6}]