[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549947":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":25,"responsibleParty":43,"collaborators":25,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":25,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":25,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":72,"whyStopped":25,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":25},{"fullName":5,"class":6},"King Saud University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Lifestyle Modification Group (LMP)","ACTIVE_COMPARATOR","They are the people who will follow the lifestyle modification program, which is:\n\nDietary counseling and monitoring: reduce fat intake (30% of total energy and saturated fat 10% of total energy) and increase fiber intake (15 g\u002F1000 kcal) in the diet Physical activity: moderate exercise (150 minutes\u002Fweek)",[13,14],"Other: Providing nutritional counselling","Other: counseling on physical activity",{"label":16,"type":17,"description":18,"interventionNames":19},"Control group (CG)","PLACEBO_COMPARATOR","They are people who will not follow the lifestyle modification program or they did not know about this program",[13,14],[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Providing nutritional counselling","Dietary counseling and monitoring:\n\nReduce fat intake (30% of total energy and saturated fat 10% of total energy) and increase fiber intake (15 g\u002F1000 kcal) in the diet.\n\nParticipants will receive individual, detailed, ongoing nutritional counseling by the study dietitian every two weeks.",[16,9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"counseling on physical activity","Physical activity:\n\nParticipants will also be encouraged to participate in physical activities. moderate exercise (150 minutes\u002Fweek)",[16,9],[31],{"name":32,"affiliation":5,"role":33},"Shaun B Sabico, M.D.PhD","STUDY_CHAIR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Ahmed S Alenezi, PhD","CONTACT","00966505384985","444105554@student.ksu.edu.sa",{"name":32,"role":37,"phone":41,"phoneExt":25,"email":42},"00966114675939","ssabico@ksu.edu.sa",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Ahmed Shafi Alenezi","Principle Investigator","100549947","effects-of-lifestyle-intervention-in-the-biological-aging-in-prediabetes-100549947",false,"NCT06440681","Effects of Lifestyle Intervention in the Biological Aging in Prediabetes","Effects of a 6-month Lifestyle Intervention Program in the DNAm PhenoAge, SOST, and GDF15 Markers of Biological Aging in Adults With Prediabetes","Inclusion Criteria:\n\n1. Clinical diagnosis of pre-diabetes for all Saudis aged 30 years and above, males and females\n2. They must be able to exercise and be able to follow a diet\n\nExclusion Criteria\n\n1. Insulin-dependent diabetes and non-diabetic patients\n2. People with diseases that prevent them from participating and doing exercises","ALL","30 Years","80 Years",{"count":58,"type":59},500,"ESTIMATED","INTERVENTIONAL",[62],"NA","Lifestyle modifications, including dietary changes and increased physical activity, play a crucial role in controlling complications to reduce or eliminate them. As well as controlling disturbances in biochemical markers such as DNAm PhenoAge, and signs of aging such as circulating sclerostin (SOST) and growth differentiation factor 15 (GDF15). This study seeks to address this dilemma by focusing on specific groups of elderly Saudis with prediabetes . Lifestyle changes in elderly Saudis with prediabetes show promise in reducing or eliminating complications. The potential insights derived from this research extend beyond academia, offering tangible benefits for clinical practice and public health\n\nThe proposed study will be implemented to achieve the following objective:\n\n1. To determine changes in DNAm PhenoAge of elderly Saudis with prediabetes who underwent a 6-month lifestyle modification program.\n2. To determine changes in other candidate senescence markers such as circulating sclerostin (SOST) and growth differentiation factor 15 (GDF15) of elderly Saudis with prediabetes who underwent a 6-month lifestyle modification program.",[65,66],"PreDiabetes","Marker; Structural",[68,69,70,71],"DNAm PhenoAge","Lifestyle modification","SOST","DGF-15","NOT_YET_RECRUITING","2024-06-08",{"date":75,"type":76},"2024-06-11","ACTUAL",{"date":78,"type":59},"2024-08-01",{"date":80,"type":59},"2025-11-01",{"name":5,"class":6}]