[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642511":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":42,"centralContacts":46,"locations":32,"responsibleParty":52,"collaborators":56,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":32,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":85,"whyStopped":32,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":32},{"fullName":5,"class":6},"Istinye University","OTHER",[8,15,21],{"label":9,"type":10,"description":11,"interventionNames":12},"BFR Exercise Group","EXPERIMENTAL","Participants will perform a supervised low-load exercise program twice weekly for 8 weeks combined with blood flow restriction applied to both proximal thighs at 50-60% of individually determined arterial occlusion pressure during the strengthening component of the intervention.",[13,14],"Device: Blood Flow Restriction Training","Behavioral: Low-Load Exercise Program",{"label":16,"type":17,"description":18,"interventionNames":19},"Sham BFR Group","SHAM_COMPARATOR","Participants will perform the same supervised low-load exercise program twice weekly for 8 weeks. Pneumatic cuffs will be applied to both proximal thighs but inflated to a pressure insufficient to produce meaningful vascular occlusion.",[20,14],"Device: Sham Blood Flow Restriction",{"label":22,"type":23,"description":24,"interventionNames":25},"Exercise Control Group","ACTIVE_COMPARATOR","Participants will perform the same supervised low-load exercise program twice weekly for 8 weeks without blood flow restriction.",[14],[27,33,37],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","Blood Flow Restriction Training","Low-load exercise performed with individualized blood flow restriction applied to both proximal thighs using pneumatic cuffs inflated to 50-60% of arterial occlusion pressure.",[9],null,{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Sham Blood Flow Restriction","Low-load exercise performed with pneumatic cuffs applied to both proximal thighs but inflated to a pressure insufficient to produce meaningful vascular occlusion.",[16],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":32},"BEHAVIORAL","Low-Load Exercise Program","Participants will perform a supervised low-load exercise program twice weekly for 8 weeks. The exercise program will include warm-up activities, quadriceps-focused strengthening exercises, cycling exercise, and cool-down activities. The same exercise program will be applied to all study groups.",[9,22,16],[43],{"name":44,"affiliation":5,"role":45},"seçil özkurt, Dr.","STUDY_DIRECTOR",[47],{"name":48,"role":49,"phone":50,"phoneExt":32,"email":51},"Hanifi BAL, pt","CONTACT","+905532139440","fzt.hanifibal@outlook.com",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"SPONSOR_INVESTIGATOR","Hanifi Bal","ınvestigator",[57],{"name":58,"class":6},"Dicle University","100642511","effects-of-low-load-blood-flow-restriction-exercise-on-rectus-femoris-muscle-morphology-in-individuals-with-relapsing-remitting-multiple-sclerosis-100642511",false,"NCT07645937","Effects of Low-Load Blood Flow Restriction Exercise on Rectus Femoris Muscle Morphology in Individuals With Relapsing-Remitting Multiple Sclerosis","Effects of Low-Load Blood Flow Restriction Exercise on Rectus Femoris Muscle Morphology in Individuals With Relapsing-Remitting Multiple Sclerosis: A Three-Arm Randomized Controlled Trial","RRMS-BFR","Inclusion Criteria:\\* Age 18-65 years\n\n* Diagnosis of relapsing-remitting multiple sclerosis according to revised McDonald criteria\n* EDSS score between 2.5 and 3.5\n* Clinically stable disease\n* No relapse within the previous 3 months\n* No corticosteroid treatment within the previous 3 months\n* Ability to participate in exercise training\n* Written informed consent\n\nExclusion Criteria:\\* Deep vein thrombosis or pulmonary embolism history\n\n* Peripheral vascular disease\n* Uncontrolled hypertension\n* Severe cardiovascular disease\n* Pregnancy\n* Recent lower extremity surgery or injury\n* Musculoskeletal or neurological conditions interfering with exercise participation\n* Contraindications to blood flow restriction training\n* Participation in another structured exercise trial during the study period","ALL","18 Years","65 Years",{"count":71,"type":72},30,"ESTIMATED","INTERVENTIONAL",[75],"NA","Multiple sclerosis (MS) is a chronic neurological disease associated with reduced muscle strength, impaired mobility, increased fatigue, and deterioration in muscle morphology. Rectus femoris muscle atrophy and reduced muscle quality have been linked to functional limitations and decreased mobility in individuals with MS.\n\nBlood flow restriction (BFR) training is a rehabilitation strategy that combines low-load exercise with partial vascular occlusion, enabling muscular adaptations comparable to those achieved with higher exercise loads. Although BFR has demonstrated promising results in several clinical populations, evidence regarding its effects on muscle morphology in individuals with relapsing-remitting multiple sclerosis (RRMS) remains limited.\n\nThe purpose of this randomized controlled trial is to investigate the effects of low-load BFR exercise on rectus femoris muscle morphology in individuals with RRMS. Thirty participants with RRMS (EDSS 2.5-3.5) will be randomly assigned to one of three groups: a BFR exercise group, a sham-BFR exercise group, or an exercise-only control group. All participants will complete the same supervised exercise program twice weekly for eight weeks.\n\nThe primary outcome will be rectus femoris muscle thickness assessed by ultrasonography. Secondary outcomes will include rectus femoris echo intensity, knee extensor muscle strength, Timed 25-Foot Walk performance, Nine-Hole Peg Test performance, Symbol Digit Modalities Test scores, and Modified Fatigue Impact Scale scores.\n\nThis study aims to determine whether the addition of blood flow restriction to a standardized low-load exercise program results in superior morphological and functional adaptations compared with sham-BFR and exercise-only conditions in individuals with RRMS.",[78],"Multiple Sclerosis (MS) - Relapsing-remitting",[80,81,82,83,84],"Relapsing-Remitting Multiple Sclerosis","Blood Flow Restriction","BFR Training","Rectus Femoris","Muscle Morphology","NOT_YET_RECRUITING","2026-06-09",{"date":88,"type":89},"2026-06-12","ACTUAL",{"date":91,"type":72},"2026-07-01",{"date":93,"type":72},"2027-04-01",{"name":54,"class":6}]