[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637766":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":23,"locations":18,"responsibleParty":29,"collaborators":18,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":35,"acronym":18,"eligibilityCriteria":36,"healthyVolunteers":33,"sex":37,"minAge":38,"maxAge":39,"enrollmentInfo":40,"targetDuration":18,"studyType":43,"phases":44,"briefSummary":46,"conditions":47,"keywords":53,"overallStatus":61,"whyStopped":18,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":18},{"fullName":5,"class":6},"Universidad Francisco de Vitoria","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Moderate-Intensity Interval Aerobic Exercise","EXPERIMENTAL","Participants perform a supervised moderate-intensity interval aerobic exercise programme during the radiotherapy treatment period. Training is conducted 3 days per week, on alternate days, under the supervision of a physiotherapist experienced in therapeutic exercise in oncology. Exercise intensity is prescribed individually according to baseline physiological testing, including lactate response, perceived exertion and clinical tolerance. Participants continue receiving standard oncological care during radiotherapy.",[13],"Other: Moderate-Intensity Interval Aerobic Exercise",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual Care During Radiotherapy","NO_INTERVENTION","Participants allocated to the control group receive standard oncological care during the radiotherapy treatment period and do not participate in a structured exercise programme during the study period. Participants are instructed to maintain their usual lifestyle throughout radiotherapy. After completion of the study, participants in the control group are offered the same supervised moderate-intensity interval aerobic exercise programme delivered to the experimental group.",null,[20],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":18},"Structured and supervised aerobic exercise intervention based on moderate-intensity interval training. The programme includes repeated aerobic exercise bouts interspersed with recovery periods. Exercise intensity is individually prescribed and adjusted according to baseline physiological assessment, including blood lactate response, perceived exertion and clinical tolerance. The intervention is delivered during the radiotherapy treatment period as an adjunct to standard oncological care.",[9],[24],{"name":25,"role":26,"phone":27,"phoneExt":18,"email":28},"África Ruiz","CONTACT","+34 913 24 80 64","africa.ruiz@ufv.es",{"type":30,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100637766","effects-of-moderate-intensity-interval-aerobic-exercise-miiae-on-inflammatory-immune-metabolic-physical-fitness-and-quality-of-life-parameters-in-breast-cancer-patients-undergoing-radiotherapy-100637766",false,"NCT07583719","Effects of Moderate-intensity Interval Aerobic Exercise (MIIAE) on Inflammatory, Immune, Metabolic, Physical Fitness, and Quality of Life Parameters in Breast Cancer Patients Undergoing Radiotherapy.","Inclusion Criteria:\n\n* Women aged between 20 and 65 years.\n* Clinical diagnosis of breast cancer (Stage I-III).\n* Patients who have undergone lumpectomy or mastectomy.\n* Scheduled to start radiotherapy treatment.\n* Sedentary lifestyle according to international physical activity guidelines.\n* Ability to understand and follow instructions.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Presence of infectious disease.\n* Cardiovascular or respiratory disease.\n* Metastatic disease.\n* Uncontrolled diabetes mellitus.\n* Neuropathy.\n* Physically active individuals meeting WHO physical activity recommendations.\n* Participation in an exercise intervention program within the last 3 months.\n* Any condition that, in the opinion of the research team, may compromise safety or participation.","FEMALE","20 Years","65 Years",{"count":41,"type":42},40,"ESTIMATED","INTERVENTIONAL",[45],"NA","Breast cancer and its treatment with radiotherapy may be associated with systemic inflammatory, hematological, cardiac, body composition, functional and quality-of-life alterations. Exercise has emerged as a non-pharmacological strategy with potential benefits during oncological treatment; however, further evidence is needed regarding the effects of supervised moderate-intensity interval aerobic exercise during radiotherapy.\n\nThis randomized controlled trial aims to evaluate the effects of a supervised moderate-intensity interval aerobic exercise programme on systemic inflammatory and immune-derived hematological indices, cardiac biomarkers, body composition, muscle strength, lower-limb power, sleep quality and breast cancer-specific quality of life in women with breast cancer undergoing radiotherapy.\n\nParticipants will be allocated to either an experimental group performing supervised moderate-intensity interval aerobic exercise during radiotherapy or to a control group receiving usual care without structured exercise during the study period. Outcomes will be assessed at baseline and after completion of the intervention period.",[48,49,50,51,52],"Radiotherapy","Inflamation","Immune System","Physical Fitness","Breast Cancer",[54,55,56,57,58,52,59,60],"Interval Training","Inflammation","Body Composition","Quality of Life","Immune function","Sleep","oncology rehabilitation","NOT_YET_RECRUITING","2026-05-06",{"date":64,"type":65},"2026-05-13","ACTUAL",{"date":67,"type":42},"2026-06-01",{"date":69,"type":42},"2026-12-31",{"name":5,"class":6}]