[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640933":3},{"organization":4,"armGroups":7,"interventions":36,"overallOfficials":58,"centralContacts":68,"locations":42,"responsibleParty":73,"collaborators":42,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":42,"eligibilityCriteria":80,"healthyVolunteers":77,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":42,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":101,"whyStopped":42,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":42},{"fullName":5,"class":6},"Riphah International University","OTHER",[8,14,20,25,30],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: Active Anodal Transcranial direct current stimulation + Task-Oriented Training","EXPERIMENTAL","Participants receive active anodal transcranial direct current stimulation (tDCS) applied concurrently with task-oriented training.",[13],"Device: Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented Training",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Transcranial direct current stimulation + Task-Oriented Training","SHAM_COMPARATOR","Participants receive sham (inactive) transcranial direct current stimulation combined with task-oriented training.",[19],"Device: Sham Active Anodal Transcranial Direct Current Stimulation + Task-Oriented Training",{"label":21,"type":10,"description":22,"interventionNames":23},"Active Anodal Transcranial direct current stimulation + Virtual Reality Therapy","Participants receive active anodal transcranial direct current stimulation (tDCS) combined with virtual reality based rehabilitation.",[24],"Device: Active Anodal Transcranial Direct Current Stimulation + Virtual Reality",{"label":26,"type":16,"description":27,"interventionNames":28},"Sham Transcranial direct current stimulation + Virtual Reality Therapy","Participants receive sham (inactive) transcranial direct current stimulation combined with virtual reality based rehabilitation.",[29],"Device: Sham Active Anodal Transcranial Direct Current Stimulation + Virtual Reality",{"label":31,"type":32,"description":33,"interventionNames":34},"Conventional Physiotherapy","ACTIVE_COMPARATOR","Participants receive conventional physiotherapy based on standard clinical practice for spastic cerebral palsy.",[35],"Other: Conventional Physiotherapy",[37,43,47,51,55],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"DEVICE","Active Anodal Transcranial Direct Current Stimulation (tDCS) + Task-Oriented Training","Active anodal transcranial direct current stimulation is delivered using a certified tDCS device at a low, safe intensity according to pediatric guidelines. Stimulation is applied to the scalp for approximately 20 minutes per session and is delivered concurrently with task-oriented training. Task-oriented activities individualized to motor deficits, emphasizing:\n\n* Functional reaching\n* Grasp-release tasks\n* Bilateral coordination\n* Balance and postural activities\n* Each session includes 10-15 task circuits, progressing from simple to complex tasks based on child performance.",[9],null,{"type":38,"name":44,"description":45,"armGroupLabels":46,"otherNames":42},"Sham Active Anodal Transcranial Direct Current Stimulation + Task-Oriented Training","Sham stimulation will mimic active tDCS for the first 30 seconds (ramp up\u002Fdown) and then deliver no current for the remainder of the session, ensuring blinding. TOT protocol is identical to Group 1.",[15],{"type":38,"name":48,"description":49,"armGroupLabels":50,"otherNames":42},"Active Anodal Transcranial Direct Current Stimulation + Virtual Reality","Active anodal transcranial direct current stimulation is delivered using a certified tDCS device at a low, safe intensity according to pediatric guidelines. Stimulation is applied to the scalp for approximately 20 minutes per session and is delivered concurrently with Virtual Reality. System: Pediatric upper-limb and balance VR rehabilitation system Activities: Interactive tasks including\n\n* reaching,\n* stepping,\n* virtual object manipulation,\n* coordination games.\n* Session duration: 30 to 40 minutes Difficulty automatically progresses based on performance metrics (speed, accuracy, movement amplitude)",[21],{"type":38,"name":52,"description":53,"armGroupLabels":54,"otherNames":42},"Sham Active Anodal Transcranial Direct Current Stimulation + Virtual Reality","Sham stimulation will mimic active tDCS for the first 30 seconds (ramp up\u002Fdown) and then deliver no current for the remainder of the session, ensuring blinding. VR protocol identical to Group 3",[26],{"type":6,"name":31,"description":56,"armGroupLabels":57,"otherNames":42},"* Stretching of spastic muscle groups\n* Strengthening exercises for weak muscle groups\n* Balance and gait training\n* Functional mobility practice\n* Session duration: 45 minutes. Delivered by a trained pediatric physiotherapist following standard clinical guidelines.",[31],[59,63,65],{"name":60,"affiliation":61,"role":62},"Qamar Mehmood, PhD","Riphah international univesty","STUDY_CHAIR",{"name":64,"affiliation":5,"role":62},"Waqar Ahmed Awan, PhD",{"name":66,"affiliation":5,"role":67},"Riafat Mehmood, PhD*","PRINCIPAL_INVESTIGATOR",[69],{"name":66,"role":70,"phone":71,"phoneExt":42,"email":72},"CONTACT","0333551063","riafat.mehmood@riphah.edu.pk",{"type":74,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100640933","effects-of-multimodal-neuro-rehabilitation-on-cortical-activity-and-muscle-syenergy-in-spastic-cerebral-palsy-100640933",false,"NCT07574996","Effects of Multimodal Neuro Rehabilitation on Cortical Activity and Muscle Syenergy in Spastic Cerebral Palsy","Inclusion Criteria:\n\n* Children aged 6-18 years.\n* Neurologist-confirmed spastic cerebral palsy.\n* GMFCS Levels I-III (mild to moderate motor impairment).\n* Ability to understand and follow simple instructions.\n* Medically stable (no planned major surgery; no recent adjustment of medications affecting cortical excitability).\n* Parental\u002Fguardian written informed consent and child assent.\n\nExclusion Criteria:\n\n* Active uncontrolled epilepsy or history of seizure in the last year.\n* Metal implants in the head or implanted medical\u002Felectrical devices (e.g., cochlear implants, ventriculoperitoneal shunts, pacemakers).\n* Significant visual or auditory impairments that would interfere with task performance.\n* Severe behavioral or cognitive difficulties that would prevent safe application of tDCS or training tasks.\n* Currently taking medications known to significantly alter cortical excitability (e.g., benzodiazepines, antiepileptics) if dosage is unstable.\n* Participation in other experimental neurorehabilitation or brain stimulation interventions within the last 6 months.","ALL","6 Years","18 Years",{"count":85,"type":86},150,"ESTIMATED","INTERVENTIONAL",[89],"NA","* To determine the effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy.\n* To determine the retention effects of tDCS in conjunction with task-oriented training (TOT) and virtual reality (VR) as compared with sham stimulation and conventional physiotherapy on cortical activity and muscle synergy, one-month follow-up across the five groups.",[92],"Cerebral Palsy",[94,95,96,97,98,31,99,100],"Spastic Cerebral Palsy","Pediatric Neurorehabilitation","Transcranial direct current stimulation","Task-oriented training","Virtual reality","Cortical Activity","Muscle synergy","NOT_YET_RECRUITING","2026-05-04",{"date":104,"type":105},"2026-05-08","ACTUAL",{"date":107,"type":86},"2026-06-01",{"date":109,"type":86},"2028-01-14",{"name":5,"class":6}]