[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626152":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":18,"responsibleParty":33,"collaborators":18,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":44,"sex":45,"minAge":46,"maxAge":18,"enrollmentInfo":47,"targetDuration":18,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":64,"whyStopped":18,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":70,"leadSponsor":72,"locationsCount":18},{"fullName":5,"class":6},"Heart and Brain Research Group, Germany","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"VR + Binaural Beats","EXPERIMENTAL","Participants receive a 30-minute immersive nature-based virtual reality relaxation intervention combined with binaural beats.",[13],"Behavioral: Nature-Based Virtual Reality With Binaural Beats",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Condition","NO_INTERVENTION","Participants undergo a control condition involving everyday cognitive activities without relaxation intervention.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Nature-Based Virtual Reality With Binaural Beats","A 30-minute immersive virtual reality exposure to natural environments combined with binaural auditory stimulation gradually decreasing from alpha to delta frequency range (10-1 Hz).",[9],[26,31],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Marius Butz, PhD, M.Sc.","CONTACT","Tel.: +49(0)6032\u002F996 5812","m.butz@kerckhoff-klinik.de",{"name":32,"role":28,"phone":18,"phoneExt":18,"email":18},"Nicole Schmidt-Bodensohn, PhD, M.Sc.",{"type":34,"investigatorFullName":27,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100626152","effects-of-nature-based-virtual-reality-and-binaural-beats-on-heart-rate-variability-and-relaxation-100626152",false,"NCT07431918","Effects of Nature-Based Virtual Reality and Binaural Beats on Heart Rate Variability and Relaxation","Effects of Nature-Based Virtual Reality and Binaural Beats on Heart Rate Variability and Relaxation: A Controlled Within-Subject Study","VRELAX","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Ability to understand study procedures and provide written informed consent\n* Sufficient proficiency in the German language to complete questionnaires and follow study instructions\n* Willingness to participate in a single approximately 60-minute study session\n\nExclusion Criteria:\n\n* Current or history of neurological or psychiatric disorders that may interfere with data collection (e.g., dementia, major depressive disorder, stroke, epilepsy)\n* Severe visual or hearing impairments that would limit the use of virtual reality equipment or headphones\n* History of adverse reactions to virtual reality",true,"ALL","18 Years",{"count":48,"type":49},18,"ESTIMATED","INTERVENTIONAL",[52],"NA","The VRELAX study is a non-clinical sub-study within the \"Decreasing Preoperative Stress to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients\"- research program (DESTRESS; NCT05036538), which investigates non-pharmacological relaxation interventions using virtual reality and binaural auditory stimulation. In a randomized counterbalanced within-subject design, non-clinical adult participants complete two sessions separated by a 1 day intervention-free interval. A 30-minute immersive nature-based virtual reality exposure combined with gradually decreasing binaural beats (10-1 Hertz (Hz)), and a control condition without relaxation. Heart rate variability (HRV) is recorded continuously, and subjective stress is assessed before and after each condition. The primary outcome is parasympathetic activation operationalized as high-frequency (HF) power of heart rate variability. Secondary outcomes include additional HRV parameters and self-reported stress ratings. The study aims to characterize short-term relaxation effects and evaluate the feasibility of independent use in everyday settings, supporting interpretation of clinical findings of the DESTRESS trial.",[55,56,57,58],"Stress","Relaxation","Virtual Reality","Binaural Beats",[57,58,60,61,62,63],"Heart Rate Variability","Stress Reduction","Relaxation Intervention","Non-Clinical Population","NOT_YET_RECRUITING","2026-02-18",{"date":67,"type":68},"2026-02-25","ACTUAL",{"date":67,"type":49},{"date":71,"type":49},"2026-12-20",{"name":5,"class":6}]