[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629434":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":24,"locations":34,"responsibleParty":46,"collaborators":18,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":18,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":18,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":74,"whyStopped":18,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Izmir Democracy University","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Adult Smokers","Adult individuals who use cigarettes will be enrolled in this observational study. Participants will be evaluated for nicotine dependence level using the Fagerström Test for Nicotine Dependence and will undergo assessments of respiratory muscle strength (MIP, MEP), functional capacity (6-Minute Walk Test), cognitive function (MoCA), pain (VAS\u002FSF-MPQ), quality of life (SF-36), physical activity level (IPAQ-SF), sleep quality (PSQI), addiction behavior model (SOCRATES), and health beliefs (Health Belief Model Scale). No intervention will be applied.",[12],"Other: Comprehensive Clinical Assessment",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":18},"Comprehensive Clinical Assessment","Participants will undergo a comprehensive clinical assessment including evaluation of nicotine dependence level (Fagerström Test for Nicotine Dependence), respiratory muscle strength (MIP, MEP), functional capacity (6-Minute Walk Test), cognitive function (MoCA), pain (VAS and SF-MPQ), quality of life (SF-36), physical activity level (IPAQ-SF), sleep quality (PSQI), addiction behavior model (SOCRATES), and health beliefs (Health Belief Model Scale). No therapeutic intervention will be administered.",[9],null,[20],{"name":21,"affiliation":22,"role":23},"Ferruh Taşpınar, Prof.Dr.","İzmir democracy","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Betül Taşpınar, Prof.Dr.","CONTACT","+90 506 680 44 26","betul.taspinar@gmail.com",{"name":31,"role":27,"phone":32,"phoneExt":18,"email":33},"Özge Kuşçu, Pt.","+90553 105 86 54","ozgekuscu26@gmail.com",[35],{"facility":36,"status":18,"city":37,"state":38,"zip":18,"country":39,"countryCode":18,"cosmosGeoPoint":40,"geoPoint":45,"contacts":18},"Betül TAŞPINAR","Konak","İ̇zmi̇r","Turkey (Türkiye)",{"type":41,"coordinates":42},"Point",[43,44],27.1,38.4,{"lat":44,"lon":43},{"type":23,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Betül Taşpınar","Prof.Dr.","100629434","effects-of-nicotine-dependence-on-multidimensional-health-outcomes-100629434",false,"NCT07474623","Effects of Nicotine Dependence on Multidimensional Health Outcomes","The Relationship Between Nicotine Addiction Level and Respiratory Muscle Strength, Functional Capacity, Cognitive Functions, Pain, Quality of Life, Physical Activity Level, and Sleep Quality","Inclusion Criteria:\n\n* Regular cigarette use for at least the past 6 months\n* No history of respiratory, cardiovascular, or neurological\u002Fpsychiatric disease\n* No recent history of surgery or trauma that could affect respiratory muscles\n* No current acute infection (especially upper or lower respiratory tract infections)\n\nExclusion Criteria:\n\n* Presence of chronic respiratory diseases such as COPD or\n* History of cardiovascular disease\n* Diagnosed neurological or psychiatric disorders\n* history of surgery or trauma affecting the respiratory muscles within the last 3 months\n* Pregnancy or suspected pregnancy",true,"ALL","18 Years","65 Years",{"count":61,"type":62},212,"ESTIMATED","INTERVENTIONAL",[65],"NA","Nicotine, a major toxic component of cigarette smoke, together with carbon monoxide (CO), constitutes a significant environmental exposure with systemic effects. Beyond its addictive potential, chronic nicotine exposure may induce inflammation, oxidative stress, tissue hypoxia, and autonomic imbalance, potentially impairing respiratory muscle strength, functional capacity, and overall physical performance. Additionally, nicotine dependence has been associated with sleep disturbances, cognitive dysfunction, altered pain perception, and reduced quality of life.\n\nAlthough previous studies have examined individual effects of smoking on specific health outcomes, research addressing these multidimensional impacts within a comprehensive framework remains limited. Therefore, this study aims to investigate the relationship between nicotine dependence level and respiratory muscle strength, functional capacity, cognitive functions, pain, quality of life, physical activity level, and sleep quality, in order to provide a more holistic understanding of the clinical consequences of nicotine dependence.",[68,69],"Tobacco Use Disorder","Nicotine Dependence, Cigarettes",[71,72,73],"Nicotine Dependence","Respiratory Muscle Strength","Quality of Life","NOT_YET_RECRUITING","2026-03-11",{"date":77,"type":78},"2026-03-16","ACTUAL",{"date":80,"type":62},"2026-04-15",{"date":82,"type":62},"2027-07-15",{"name":5,"class":6},1]