[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598579":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":24,"locations":28,"responsibleParty":48,"collaborators":24,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":24,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":31,"whyStopped":24,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of Trieste","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HYPOTRAIN","EXPERIMENTAL","This arm will perform the normobaric hypoxic aerobic training (HYPOTRAIN)",[13],"Other: HYPOTRAIN",{"label":15,"type":16,"description":17,"interventionNames":18},"NORMOTRAIN","SHAM_COMPARATOR","This arm will perform the normobaric normoxia aerobic training (NORMOTRAIN)",[19],"Other: NORMOTRAIN",[21,25],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"8 weeks of 2\u002F3 times per week, 1-h aerobic training (walking on a treadmill at 60-65% HRmax) while wearing a mask and air is delivered between 15 and 16 FiO2%",[9],null,{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"8 weeks of 2\u002F3 times per week, 1-h aerobic training (walking on a treadmill at 60-65% HRmax) while wearing a mask and air is delivered between at normal (around 21) FiO2%",[15],[29],{"facility":30,"status":31,"city":32,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"University of Trieste - Exercise Physiology and Kinesiology Lab","RECRUITING","Trieste","34100","Italy","IT",{"type":37,"coordinates":38},"Point",[39,40],13.77678,45.64953,{"lat":40,"lon":39},[43],{"name":44,"role":45,"phone":46,"phoneExt":24,"email":47},"Alex Buoite Stella, PhD","CONTACT","0039 0403996582","abuoitestella@units.it",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Alex Buoite Stella","PhD, Assistant Professor","100598579","effects-of-normobaric-hypoxic-training-in-metabolic-dysfunction-associated-steatotic-liver-disease-masld-100598579",false,"NCT07073326","Effects of Normobaric Hypoxic Training in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)","Effects of Normobaric Hypoxia Aerobic Training in People With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)","HYPOMASLD","Inclusion Criteria:\n\n* Being diagnosed with MASLD from at the least 3 years\n* BMI \\> 26 kg\u002Fm2\n* Being sedentary\n\nExclusion Criteria:\n\n* Cardiovascular, respiratory, renal complications\n* Hypertension\n* COPD\n* Previous history of acute mountain sickness or altitude-associated symptoms\n* Females only: pregnancy or breastfeeding","ALL","18 Years","50 Years",{"count":64,"type":65},20,"ESTIMATED","INTERVENTIONAL",[68],"NA","Altitude training has been suggested to be of potential support to improve some chronic clinical conditions, especially metabolic conditions. Normobaric hypoxia represents a promising system to simulate altitude training, and its efficacy and safety have been suggested in different conditions, including diabetes, obesity and hypertension. Metabolic dysfunction-associated steatotic liver disease (MASLD) can characterized by metabolic alterations (including altered body composition, lipid and glycemic profile, etc.), and might benefit from aerobic training performed in simulated altitude training (i.e., normobaric hypoxia). Mild altitude training will be proposed (equal to about 2'500 m, 15% FiO2) and compared to a sham normobaric normoxia condition, during an 8-week 3 or 2 times per week 1-h aerobic training (walking) at 60-65% of maximum heart rate (HRmax). Cardiorespiratory fitness, body composition, and metabolic profile will be investigated.",[71,72],"MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease","Normobaric Hypoxia",[74,75,76,77,78,79],"Hypoxia","Altitude","Exercise","Liver","Metabolism","Fat","2026-04-27",{"date":82,"type":83},"2026-05-04","ACTUAL",{"date":85,"type":83},"2025-09-01",{"date":87,"type":65},"2026-07",{"name":5,"class":6},1]