[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100510923":3},{"organization":4,"armGroups":7,"interventions":86,"overallOfficials":164,"centralContacts":168,"locations":177,"responsibleParty":192,"collaborators":194,"id":198,"slug":199,"hasResults":200,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":157,"eligibilityCriteria":204,"healthyVolunteers":200,"sex":205,"minAge":206,"maxAge":157,"enrollmentInfo":207,"targetDuration":157,"studyType":210,"phases":211,"briefSummary":213,"conditions":214,"keywords":216,"overallStatus":180,"whyStopped":157,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":227},{"fullName":5,"class":6},"Yale University","OTHER",[8,14,19,24,28,32,36,40,44,48,52,57,62,66,70,74,78,82],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-menthol, nicotine 59mg\u002Fml (1)","EXPERIMENTAL","Flavor without menthol with 59mg\u002Fml nicotine",[13],"Other: E-liquid coolant (No WS-3) for non-menthol (1)",{"label":15,"type":10,"description":16,"interventionNames":17},"Low (0.1%) menthol, nicotine 59mg\u002Fml (1)","Flavor with low menthol concentration with 59mg\u002Fml nicotine",[18],"Other: E-liquid coolant (No WS-3) for low (0.1%) menthol (1)",{"label":20,"type":10,"description":21,"interventionNames":22},"High (2.0%) menthol, nicotine 59mg\u002Fml (1)","Flavor with high menthol concentration with 59mg\u002Fml nicotine",[23],"Other: E-liquid coolant (No WS-3) for high (2.0%) menthol (1)",{"label":25,"type":10,"description":11,"interventionNames":26},"Non-menthol, nicotine 59mg\u002Fml (2)",[27],"Other: E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)",{"label":29,"type":10,"description":16,"interventionNames":30},"Low (0.1%) menthol, nicotine 59mg\u002Fml (2)",[31],"Other: E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol 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menthol, nicotine 59mg\u002Fml (4)","Flavor low menthol concentration with 59mg\u002Fml nicotine",[56],"Other: E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4)",{"label":58,"type":10,"description":59,"interventionNames":60},"High (2.0%) menthol, nicotine 59mg\u002Fml (4)","Flavor high menthol concentration with 59mg\u002Fml nicotine",[61],"Other: E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4)",{"label":63,"type":10,"description":11,"interventionNames":64},"Non-menthol, nicotine 59mg\u002Fml (5)",[65],"Other: E-liquid coolant (High [2.0%] WS-23) for non-menthol (5)",{"label":67,"type":10,"description":54,"interventionNames":68},"Low (0.1%) menthol, nicotine 59mg\u002Fml (5)",[69],"Other: E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5)",{"label":71,"type":10,"description":59,"interventionNames":72},"High (2.0%) menthol, nicotine 59mg\u002Fml (5)",[73],"Other: E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5)",{"label":75,"type":10,"description":11,"interventionNames":76},"Non-menthol, nicotine 59mg\u002Fml (6)",[77],"Other: E-liquid coolant (4% WS-23) for non-menthol (6)",{"label":79,"type":10,"description":54,"interventionNames":80},"Low (0.1%) menthol, nicotine 59mg\u002Fml (6)",[81],"Other: E-liquid coolant (4% WS-23) for low (0.1%) menthol (6)",{"label":83,"type":10,"description":59,"interventionNames":84},"High (2.0%) menthol, nicotine 59mg\u002Fml (6)",[85],"Other: E-liquid coolant (4% WS-23) for high (2.0%) menthol (6)",[87,93,97,101,106,110,114,119,123,127,132,136,140,145,149,153,158,161],{"type":6,"name":88,"description":89,"armGroupLabels":90,"otherNames":91},"E-liquid coolant (No WS-3) for non-menthol (1)","Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.",[9],[92],"Flavor type",{"type":6,"name":94,"description":89,"armGroupLabels":95,"otherNames":96},"E-liquid coolant (No WS-3) for low (0.1%) menthol (1)",[15],[92],{"type":6,"name":98,"description":89,"armGroupLabels":99,"otherNames":100},"E-liquid coolant (No WS-3) for high (2.0%) menthol (1)",[20],[92],{"type":6,"name":102,"description":103,"armGroupLabels":104,"otherNames":105},"E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)","Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.",[25],[92],{"type":6,"name":107,"description":103,"armGroupLabels":108,"otherNames":109},"E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2)",[29],[92],{"type":6,"name":111,"description":103,"armGroupLabels":112,"otherNames":113},"E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2)",[33],[92],{"type":6,"name":115,"description":116,"armGroupLabels":117,"otherNames":118},"E-liquid coolant (High [2.0%] WS-3) for non-menthol (3)","Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-3 concentration.",[37],[92],{"type":6,"name":120,"description":116,"armGroupLabels":121,"otherNames":122},"E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3)",[41],[92],{"type":6,"name":124,"description":116,"armGroupLabels":125,"otherNames":126},"E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3)",[45],[92],{"type":6,"name":128,"description":129,"armGroupLabels":130,"otherNames":131},"E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4)","Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-23 concentration.",[49],[92],{"type":6,"name":133,"description":129,"armGroupLabels":134,"otherNames":135},"E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4)",[53],[92],{"type":6,"name":137,"description":129,"armGroupLabels":138,"otherNames":139},"E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4)",[58],[92],{"type":6,"name":141,"description":142,"armGroupLabels":143,"otherNames":144},"E-liquid coolant (High [2.0%] WS-23) for non-menthol (5)","Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-23 concentration.",[63],[92],{"type":6,"name":146,"description":142,"armGroupLabels":147,"otherNames":148},"E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5)",[67],[92],{"type":6,"name":150,"description":142,"armGroupLabels":151,"otherNames":152},"E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5)",[71],[92],{"type":6,"name":154,"description":155,"armGroupLabels":156,"otherNames":157},"E-liquid coolant (4% WS-23) for non-menthol (6)","Adult users of e-cigarette will be exposed to distinct e-liquid coolants with 4% WS-23 concentration.",[75],null,{"type":6,"name":159,"description":155,"armGroupLabels":160,"otherNames":157},"E-liquid coolant (4% WS-23) for low (0.1%) menthol (6)",[79],{"type":6,"name":162,"description":155,"armGroupLabels":163,"otherNames":157},"E-liquid coolant (4% WS-23) for high (2.0%) menthol (6)",[83],[165],{"name":166,"affiliation":5,"role":167},"Suchitra Krishnan-Sarin, PhD","PRINCIPAL_INVESTIGATOR",[169,174],{"name":170,"role":171,"phone":172,"phoneExt":157,"email":173},"Danielle Davis, PhD","CONTACT","203-974-7607","danielle.davis@yale.edu",{"name":175,"role":171,"phone":157,"phoneExt":157,"email":176},"Wei Li, PhD","wei.vanness.li@yale.edu",[178],{"facility":179,"status":180,"city":181,"state":182,"zip":183,"country":184,"countryCode":185,"cosmosGeoPoint":186,"geoPoint":191,"contacts":157},"JB Pierce Lab","RECRUITING","New Haven","Connecticut","06519","United States","US",{"type":187,"coordinates":188},"Point",[189,190],-72.92816,41.30815,{"lat":190,"lon":189},{"type":193,"investigatorFullName":157,"investigatorTitle":157,"investigatorAffiliation":157,"oldNameTitle":157,"oldOrganization":157},"SPONSOR",[195],{"name":196,"class":197},"National Institute on Drug Abuse (NIDA)","NIH","100510923","effects-of-novel-e-cigarette-constituents-on-adults-tcors-30-100510923",false,"NCT05932745","Effects of Novel E-cigarette Constituents on Adults TCORS 3.0","Examining Appeal and Addiction Potential of Novel E-cigarette Constituents Among Adults","Inclusion Criteria:\n\n* 18 years or older\n* Able to read and write\n* Some current e-cigarette use\n* Urine cotinine ≥200ng\u002Fml\n* Willing to abstain from tobacco\u002Fnicotine use 2 hours prior to sessions\n\nExclusion Criteria:\n\n* Current use of non-prescription substances besides nicotine, marijuana, alcohol\n* Any significant current medical or psychiatric condition\n* Known hypersensitivity to propylene glycol\n* Pregnant or lactating females\n* Uncontrolled asthma\n* Nut\u002Fe-liquid flavorant allergy\n* Current marijuana (tetrahydrocannabinol) vaping + E-cigarette or vaping use Associated Lung Injury (EVALI) symptoms\n* Dislike of menthol flavor","ALL","18 Years",{"count":208,"type":209},66,"ESTIMATED","INTERVENTIONAL",[212],"NA","This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.",[215],"Nicotine Use Disorder",[217],"Menthol, cooling components, cigarette, e-cigarette, vaping","2026-06-12",{"date":220,"type":221},"2026-06-16","ACTUAL",{"date":223,"type":221},"2025-06-20",{"date":225,"type":209},"2026-08",{"name":5,"class":6},1]