[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617991":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":41,"responsibleParty":58,"collaborators":35,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":35,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":35,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":83,"overallStatus":43,"whyStopped":35,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Periodic Alveolar Recruitment Maneuver Group","EXPERIMENTAL","Participants assigned to this arm will receive standardized general anesthesia and mechanical ventilation according to routine clinical practice. After prone positioning, all participants will undergo a baseline alveolar recruitment maneuver performed within established clinical safety limits.\n\nIn this experimental arm, additional alveolar recruitment maneuvers will be applied approximately once per hour throughout the intraoperative period to help maintain lung aeration. A final recruitment maneuver will also be performed before extubation as part of standard anesthetic care. Apart from the timing of recruitment maneuvers, intraoperative anesthetic and ventilatory management will be conducted according to routine clinical practice and individualized based on patient requirements.",[13],"Procedure: Alveolar Recruitment Maneuver",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Alveolar Recruitment Maneuver Group","ACTIVE_COMPARATOR","Participants assigned to this arm will receive standardized general anesthesia and mechanical ventilation according to routine clinical practice. After prone positioning, a baseline alveolar recruitment maneuver will be performed within established clinical safety limits.\n\nNo additional recruitment maneuvers will be applied during the intraoperative period apart from a final recruitment maneuver performed before extubation as part of standard anesthetic care. Intraoperative anesthetic and ventilatory management will otherwise follow routine clinical practice and will be guided by patient safety considerations.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Alveolar Recruitment Maneuver","Alveolar recruitment maneuvers will be performed under general anesthesia using standard mechanical ventilation techniques within routine clinical safety limits. After prone positioning, a baseline recruitment maneuver will be applied by stepwise increasing positive end-expiratory pressure (PEEP) from 8 cmH₂O to 10 cmH₂O and 15 cmH₂O while maintaining an upper airway pressure limit of ≤30 cmH₂O for approximately 10 seconds. Following the maneuver, mechanical ventilation will continue with a PEEP level of approximately 8 cmH₂O according to routine clinical practice.\n\nIn the periodic recruitment group, additional recruitment maneuvers will be repeated approximately once per hour during the intraoperative period. In the standard recruitment group, no additional intraoperative maneuvers will be applied apart from a final recruitment maneuver performed before extubation as part of routine anesthetic care.",[9,15],[26],"Lung Recruitment Maneuver",[28],{"name":29,"affiliation":5,"role":30},"Serap KARACALAR, MD (Doctor of Medicine)","PRINCIPAL_INVESTIGATOR",[32,37],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":36},"CONTACT","+90 532 395 93 03",null,"skaracalar@yahoo.com",{"name":38,"role":33,"phone":39,"phoneExt":35,"email":40},"Serencan OZER, MD (Doctor of Medicine)","+90 506 423 96 68","serencanozalp@gmail.com",[42],{"facility":5,"status":43,"city":44,"state":35,"zip":35,"country":45,"countryCode":35,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Istanbul","Turkey (Türkiye)",{"type":47,"coordinates":48},"Point",[49,50],28.94966,41.01384,{"lat":50,"lon":49},[53,54,55,56],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":36},{"name":38,"role":33,"phone":39,"phoneExt":35,"email":40},{"name":29,"role":30,"phone":35,"phoneExt":35,"email":35},{"name":38,"role":57,"phone":35,"phoneExt":35,"email":35},"SUB_INVESTIGATOR",{"type":30,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"SERAP KARACALAR","Professor of Anesthesiology and Reanimation","100617991","effects-of-periodic-recruitment-maneuvers-on-atelectasis-and-respiratory-mechanics-during-elective-spine-surgery-assessed-by-lung-ultrasonography-100617991",false,"NCT07325812","Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography","Evaluation of the Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics in Elective Spine Surgery Using Lung Ultrasonography","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* Scheduled for elective lumbar spine surgery under general anesthesia\n* Surgery planned to be performed in the prone position\n* Expected surgical duration of at least 2 hours\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) greater than 30 kg\u002Fm²\n* History of thoracic surgery\n* Known or suspected chronic pulmonary disease (e.g., chronic obstructive pulmonary disease, restrictive lung disease)\n* Clinically significant cardiac disease\n* Pregnancy or breastfeeding\n* Known airway anomalies\n\nIntraoperative surgical duration shorter than 2 hours\n\nRefusal or inability to provide informed consent","ALL","18 Years","65 Years",{"count":72,"type":73},60,"ESTIMATED","INTERVENTIONAL",[76],"NA","During general anesthesia, particularly in patients undergoing spine surgery in the prone (face-down) position, increased intrathoracic and abdominal pressure may reduce lung compliance and promote the development of atelectasis (partial lung collapse). Atelectasis can impair intraoperative oxygenation and may increase the risk of postoperative pulmonary complications. Alveolar recruitment maneuvers (ARM) are routinely used in anesthesia practice to reopen collapsed lung regions; however, it remains unclear whether periodic application of ARM throughout surgery provides additional benefit compared with standard single-time application.\n\nThis prospective, randomized controlled clinical study aims to evaluate whether periodic alveolar recruitment maneuvers applied during elective spine surgery in the prone position reduce intraoperative atelectasis and improve respiratory mechanics compared with the standard approach of performing ARM only after positioning and before extubation. Adult patients undergoing elective spine surgery under general anesthesia will be randomly assigned to either a periodic ARM group or a standard ARM group.\n\nLung aeration will be assessed using lung ultrasound, a non-invasive and radiation-free bedside imaging method. The primary outcome is the incidence of intraoperative atelectasis assessed before extubation. Secondary outcomes include lung ultrasound aeration scores, respiratory mechanics parameters (such as airway pressures and compliance), oxygenation indices, and the occurrence of transient intraoperative respiratory or hemodynamic events.\n\nThe findings of this study may help optimize intraoperative ventilation strategies in prone spine surgery and contribute to improved perioperative respiratory safety.",[79,80,81,82],"Atelectasis","Mechanical Ventilation","General Anesthesia","Prone Position",[79,22,84,82,85],"Lung Ultrasound","Respiratory Mechanics","2026-04-02",{"date":88,"type":89},"2026-04-08","ACTUAL",{"date":91,"type":73},"2026-04",{"date":93,"type":73},"2026-07",{"name":5,"class":6},1]