[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615048":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":37,"centralContacts":41,"locations":47,"responsibleParty":68,"collaborators":27,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":73,"sex":79,"minAge":80,"maxAge":27,"enrollmentInfo":81,"targetDuration":27,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":50,"whyStopped":27,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Uskudar University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Arm: Active Treatment","EXPERIMENTAL","Participants in this arm will receive active transcranial photobiomodulation delivered at gamma frequency while simultaneously participating in a structured cognitive rehabilitation session. The photobiomodulation device will be placed on the participant's head and will operate continuously for 20 minutes during each session. Cognitive rehabilitation tasks will be administered throughout the stimulation period to enhance cognitive engagement. This combined intervention will be applied across all scheduled treatment sessions.",[13,14],"Device: Active transcranial Photobiomodulation","Behavioral: Cognitive Rehabilitation",{"label":16,"type":17,"description":18,"interventionNames":19},"Control Arm: Sham\u002FPlacebo","SHAM_COMPARATOR","Participants in this arm will receive sham transcranial photobiomodulation while completing the same cognitive rehabilitation session provided to the experimental group. The device will be placed on the participant's head and will appear to operate normally; however, no active light output will be delivered. Each session lasts 20 minutes, during which participants complete standardized cognitive rehabilitation tasks. Session frequency, duration, and rehabilitation procedures are identical to the experimental arm to maintain blinding and ensure comparable conditions.",[20,14],"Device: sham transcranial Photobiomodulation",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DEVICE","Active transcranial Photobiomodulation","The active intervention consists of transcranial photobiomodulation (t-PBM) delivered while the device is placed on the participant's head and operating at gamma-frequency. The device provides active near-infrared light output throughout the 20-minute session. Active intervention is administered for a total of 8 sessions.",[9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"sham transcranial Photobiomodulation","The sham intervention uses the same transcranial photobiomodulation (t-PBM) device and head placement as the active intervention; however, no therapeutic near-infrared light output is delivered. The device's external indicators remain active to mimic real stimulation and maintain participant blinding. Each session lasts 20 minutes. The sham intervention is administered for a total of 8 sessions.",[16],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":27},"BEHAVIORAL","Cognitive Rehabilitation","The cognitive rehabilitation program consists of 8 sessions, each lasting 20 minutes, delivered simultaneously with either active or sham transcranial photobiomodulation (t-PBM). The program is a pen-and-paper-based cognitive exercise protocol targeting attention, memory, executive functions, and language. Each session includes structured tasks with predefined difficulty levels. Task difficulty increases progressively by 0.5 points from Session 1 onward, ensuring gradual cognitive challenge and adaptation across all eight sessions. The rehabilitation protocol is identical for both study arms.",[16,9],[38],{"name":39,"affiliation":5,"role":40},"Baris Metin, Prof. Dr.","PRINCIPAL_INVESTIGATOR",[42],{"name":43,"role":44,"phone":45,"phoneExt":27,"email":46},"Shams Farhad, PhD","CONTACT","+905528566917","shams.farhad@uskudar.edu.tr",[48,62],{"facility":49,"status":50,"city":51,"state":27,"zip":27,"country":52,"countryCode":27,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"NPIstanbul Brain Hospital","RECRUITING","Istanbul","Turkey (Türkiye)",{"type":54,"coordinates":55},"Point",[56,57],28.94966,41.01384,{"lat":57,"lon":56},[60],{"name":43,"role":44,"phone":61,"phoneExt":27,"email":46},"+90 5528566917",{"facility":63,"status":50,"city":64,"state":27,"zip":27,"country":52,"countryCode":27,"cosmosGeoPoint":27,"geoPoint":27,"contacts":65},"Uskudar University, Faculty of Medicine","Istnabul",[66],{"name":67,"role":44,"phone":45,"phoneExt":27,"email":46},"shams.farhad@uskudar.edu.tr Farhad, PhD candidate",{"type":40,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Baris Metin","Prof. Dr.","100615048","effects-of-photobiomodularion-on-brain-connectivity-and-cognitive-function-in-cognitive-impairment-100615048",false,"NCT07287527","Effects of Photobiomodularion on Brain Connectivity and Cognitive Function in Cognitive Impairment","The Effects of Transcranial Photobiomodulation (t-PBM) on Cognitive Performance and Functional Brain Connectivity in Patients With Mild Cognitive Impairment and the Role of Genetic Factors","PBM-CogConnect","Inclusion Criteria:\n\n* Age 55 years or older\n* Diagnosis of amnestic Mild Cognitive Impairment (aMCI)\n\nExclusion Criteria:\n\n* Presence of a neurological disorder\n* Presence of a severe psychiatric disorder\n* Having a pacemaker or other implanted medical device that is not MRI-compatible","ALL","55 Years",{"count":82,"type":83},60,"ESTIMATED","INTERVENTIONAL",[86],"NA","The goal of this clinical trial is to learn if transcranial photobiomodulation (t-PBM), a light-based brain therapy, can help improve memory and cognitive skills in older adults with amnestic mild cognitive impairment (aMCI). This condition involves memory problems that are greater than normal aging and may increase the chance of developing Alzheimer's disease.\n\nThe main questions this study aims to answer are:\n\n1. Does t-PBM, when used together with cognitive training, improve memory and cognitive skills?\n2. Does t-PBM change how certain brain areas communicate with each other, especially in the default mode network (DMN)?\n\nResearchers will compare:\n\nt-PBM plus cognitive training to sham (inactive) t-PBM plus the same cognitive training to see if the active light treatment leads to better cognitive improvement and healthier brain activity.\n\nParticipants will:\n\n* Provide a blood sample so the research team can create a genetic profile;\n* Complete cognitive tests before and after the 4-week program;\n* Meet with a dietitian before and after the program so the research team can make sure diet stays consistent and does not influence brain results;\n* Have a brain fMRI scan before and after treatment to measure brain connectivity changes;\n* Take part in eight sessions of cognitive training;\n* Receive either active t-PBM or sham t-PBM during these sessions.",[89],"AMCI - Amnestic Mild Cognitive Impairment",[91,92,93,34,94,95,96],"t-PBM","aMCI","fMRI","functional connectivity","APOE","COMT","2025-12-13",{"date":99,"type":100},"2025-12-17","ACTUAL",{"date":102,"type":100},"2024-03-30",{"date":104,"type":83},"2026-10",{"name":5,"class":6},2]