[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601850":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":71,"collaborators":74,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":24,"eligibilityCriteria":86,"healthyVolunteers":82,"sex":87,"minAge":88,"maxAge":24,"enrollmentInfo":89,"targetDuration":24,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":24,"overallStatus":60,"whyStopped":24,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"University of California, Los Angeles","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Participants in this arm will be consuming 237 ml of pomegranate juice for the first 8 weeks of the study and their habitual diet without pomegranate juice for the second 8 weeks",[13],"Other: pomegranate juice -> habitual diet",{"label":15,"type":10,"description":16,"interventionNames":17},"Delayed start","Participants in this arm will consume their habitual diet for the first 8 weeks of the study and drink 237 ml of pomegranate juice for the second 8 weeks",[18],"Other: habitual diet -> pomegranate juice",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"pomegranate juice -> habitual diet","237 ml of pomegranate juice for the first 8 weeks -\\> habitual diet for the second 8 weeks",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"habitual diet -> pomegranate juice","habitual diet for the first 8 weeks -\\> 237 ml of pomegranate juice for the second 8 weeks",[15],[30],{"name":31,"affiliation":5,"role":32},"Zhaoping Li, MD, PhD","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":24,"email":38},"Tatiana Diacova, PhD, MS, RDN","CONTACT","310-206-8292","tdiacova@mednet.ucla.edu",[40,58],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"West Los Angeles VA Medical Center","NOT_YET_RECRUITING","Los Angeles","California","90073","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-118.24368,34.05223,{"lat":52,"lon":51},[55,57],{"name":56,"role":36,"phone":37,"phoneExt":24,"email":38},"Tatiana Diacova, PhD, MS, RD",{"name":31,"role":32,"phone":24,"phoneExt":24,"email":24},{"facility":59,"status":60,"city":43,"state":44,"zip":61,"country":46,"countryCode":47,"cosmosGeoPoint":62,"geoPoint":64,"contacts":65},"UCLA Center for Human Nutrition","RECRUITING","90095",{"type":49,"coordinates":63},[51,52],{"lat":52,"lon":51},[66,67,68],{"name":56,"role":36,"phone":37,"phoneExt":24,"email":38},{"name":31,"role":32,"phone":24,"phoneExt":24,"email":24},{"name":69,"role":70,"phone":24,"phoneExt":24,"email":24},"Berkeley Limketkai, MD, PhD","SUB_INVESTIGATOR",{"type":32,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Zhaoping Li","Principal Investigator",[75,78],{"name":76,"class":77},"National Institutes of Health (NIH)","NIH",{"name":79,"class":77},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","100601850","effects-of-pomegranate-juice-on-ulcerative-colitis-100601850",false,"NCT07115862","Effects of Pomegranate Juice on Ulcerative Colitis","Effect of Pomegranate Juice on Gut Inflammation, Quality of Life and the Gut Microbiome in Patients With Ulcerative Colitis: A Pilot Study","Inclusion Criteria:\n\n* • Adults ≥ 18 yo\n\n  * Following a low-polyphenol and fiber diet (\\\u003C 3 servings of fruits\u002Fvegetables per day)\n  * Mild-to-moderate UC at the time of screening (2 ≤ partial Mayo scores ≤ 5)\n  * Supportive evidence of active inflammation (hsCRP \\>1 mg\u002FL, fecal calprotectin \\>50 µg\u002Fg stool, or abnormal lower endoscopy) in individuals with biopsy-proven UC\n  * Patients on 5-aminosalicylates must be on a stable dose for ≥ 4 weeks prior to screening\n  * Patients on treatment with immunosuppressive therapy (e.g., azathioprine\u002F6-mercaptopurine, methotrexate) must be on stable dose for 8 weeks prior to baseline visit\n  * At the time of baseline visit, patients may be on no more than 20 mg\u002Fday of prednisone and 9 mg\u002Fday of budesonide MMX\n  * Subjects must read and sign the Institutional Review Board-approved written informed consent prior to the initiation of any study specific procedures or enrollment. A subject will be excluded for any condition that might compromise the ability to give truly informed consent.\n\nExclusion Criteria:\n\n* • Non-English speaker\n\n  * Vegetarian\u002Fvegan\n  * Known pomegranate allergy\n  * Documented chronic disease besides UC, including diabetes, renal or liver diseases, metabolic syndrome, active cancer, MI or stroke, history of gastric bypass\n  * Patients with CD, indeterminate\u002Fsevere to fulminant colitis\n  * History of colectomy or colonic dysplasia\n  * Presence of ileal pouch or ostomy\n  * Evidence of active bacterial or viral gastroenteritis as indicated by positive stool studies for ova \\& parasites, Clostridium difficile, and stool culture\n  * Recent hospitalizations (within 2 weeks of screening) for UC requiring IV steroids\n  * Presence of the following labs indicative of severe colitis: a. Hemoglobin \\\u003C 8.0 g\u002Fdl b. Albumin \\\u003C 3.0 g\u002Fdl\n  * Recent systemic antibiotics use (within 3 months of screening) or active use of anti-diarrheal medications\n  * Taking supplements known to affect metabolism or gut microbiota composition (probiotics, fiber, etc.), unless willing to stop for the study duration\n  * Use of Total Parenteral Nutrition (TPN)\n  * Use of cyclosporine, tacrolimus, or thalidomide within 2 months prior to screening\n  * Taking exogenous hormones (e.g., hormone replacement therapy)\n  * Recent weight fluctuations (\\>10% in the last 6 months)\n  * Smoker or living with a smoker\n  * Use of \\>20 g of alcohol per day\n  * Unable or unwilling to comply with the study protocol (including unwillingness to avoid watermelon and other lycopene-rich foods for the whole duration of the study)\n  * Unable to provide consent","ALL","18 Years",{"count":90,"type":91},30,"ESTIMATED","INTERVENTIONAL",[94],"NA","The purpose of this study is to determine whether consumption of 237 ml of pomegranate juice daily for 8 weeks will:\n\n1. lower inflammation (in the gut as well as generally in the body) and improve your overall quality of life\n2. affect the microbes living in the gut (gut microbiota)",[97],"Ulcerative Colitis (Disorder)","2025-12-08",{"date":100,"type":101},"2025-12-09","ACTUAL",{"date":103,"type":101},"2025-10-15",{"date":105,"type":91},"2027-10-15",{"name":5,"class":6},2]