[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613978":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":43,"responsibleParty":62,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":25,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University Hospital, Basel, Switzerland","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"1. Supine position 2. Prone Position","EXPERIMENTAL","First body position: randomized to supine position. Randomization of starting PEEP (0 or 15 mbar) in first body position and sequence of measurements.\n\nSecond body position: Prone Position. Randomization of starting PEEP (0 or 15 mbar) in second body position and sequence of measurements.",[13,14],"Diagnostic Test: application of PEEP: starting PEEP = 15 mbar","Diagnostic Test: application of PEEP: starting PEEP = 0 mbar",{"label":16,"type":10,"description":17,"interventionNames":18},"1. Prone Position 2. Supine Position","First body position: randomized to prone position. Randomization of starting PEEP (0 or 15 mbar) in first body position and sequence of measurements.\n\nSecond body position: Supine Position. Randomization of starting PEEP (0 or 15 mbar) in second body position and sequence of measurements.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","application of PEEP: starting PEEP = 15 mbar","The application of PEEP will be delivered by a intensive care respirator with dedicated NIV- mode (Hamilton C1, Hamilton Medical AG, Bonaduz Switzerland) via mask (VariFit, Sleepnet Corporation, New Hampshire, USA) available in four sizes (S, M, L, XL). Pressure support will be set at 5 mbar, and trigger will be adjusted according to participants' comfort. Fraction of inspired oxygen will be 0.21. If starting PEEP = 15 mbar:\n\n5 min stepwise increase of PEEP Measurements with decremental PEEP (15, 10, 5, 0 mbar)",[16,9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"application of PEEP: starting PEEP = 0 mbar","The application of PEEP will be delivered by a intensive care respirator with dedicated NIV- mode (Hamilton C1, Hamilton Medical AG, Bonaduz Switzerland) via mask (VariFit, Sleepnet Corporation, New Hampshire, USA) available in four sizes (S, M, L, XL). Pressure support will be set at 5 mbar, and trigger will be adjusted according to participants' comfort. Fraction of inspired oxygen will be 0.21. If starting PEEP = 0 mbar: Measurement with increasing PEEP (0, 5, 10, 15 mbar)",[16,9],[31],{"name":32,"affiliation":33,"role":34},"Gregor Loosen, Dr. med.","University Hospital Basel, Intensive Care Unit","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+41 61 328 40 90","gregormichael.loosen@usb.ch",{"name":41,"role":37,"phone":25,"phoneExt":25,"email":42},"Kaspar Bachmann, PD Dr. med.","kaspar.bachmann@usb.ch",[44],{"facility":33,"status":45,"city":46,"state":25,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Basel","4031","Switzerland","CH",{"type":51,"coordinates":52},"Point",[53,54],7.57327,47.55839,{"lat":54,"lon":53},[57,58,59],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},{"name":32,"role":34,"phone":25,"phoneExt":25,"email":25},{"name":60,"role":61,"phone":25,"phoneExt":25,"email":25},"Sebastian Berger, Dr. med.","SUB_INVESTIGATOR",{"type":63,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100613978","effects-of-positive-end-expiratory-pressure-peep-and-prone-positioning-in-healthy-volunteers-on-venous-hemodynamics-including-the-venous-excess-ultrasound-vexus-score-100613978",false,"NCT07273617","Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score","VeNIVPro","Inclusion Criteria:\n\n* Voluntary participants ≥ 18 years in good overall health with no relevant organ dysfunction in their medical history and signed informed consent form.\n\nExclusion Criteria:\n\n* Non-French or non-German speakers\n* Unable to provide informed consent\n* Body mass index \\> 40kg\u002Fm\n* Self-reported pregnancy\n* History of pneumothorax\n* Previously participated in the study",true,"ALL","18 Years",{"count":75,"type":76},40,"ESTIMATED","INTERVENTIONAL",[79],"NA","The hemodynamic effects of proning and PEEP may vary depending on pre- existing cardiac function, lung mechanics, and volume status, and the available evidence remains conflicting. The impact on the VExUS score of these manoeuvres is unclear. This study aims to assess the effects of PEEP in supine and prone position on the VExUS score as well as echocardiographic parameters in a cohort of healthy volunteers.",[82],"Venous Hemodynamics",[84,85,86,87],"Positive End-Expiratory Pressure (PEEP)","Venous Excess Ultrasound (VExUS) score","Venous congestion","Proning","2025-11-27",{"date":90,"type":91},"2025-12-09","ACTUAL",{"date":93,"type":91},"2025-09-25",{"date":95,"type":76},"2026-06",{"name":5,"class":6},1]