[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643092":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":65,"collaborators":25,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":25,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Lahore University of Biological and Applied Sciences","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Blood Flow Restriction Exercises and Conventional Physical therapy","EXPERIMENTAL","Participants in the experimental group will receive progressive blood flow restriction (BFR) exercise combined with conventional physical therapy following total knee arthroplasty. BFR will be applied using a pneumatic cuff placed proximally on the operated thigh at 20-40% limb occlusion pressure. Low-load therapeutic exercises will be performed under cuff inflation, including quadriceps sets, straight leg raises, heel slides, ankle pumps, sit-to-stand training, gait training, and functional strengthening exercises. Sessions will be conducted three times per week for 6 weeks under physiotherapist supervision in addition to standard postoperative rehabilitation.",[13],"Other: Blood Flow Restriction Exercises and Conventional Physical Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional Physical Therapy Alone","ACTIVE_COMPARATOR","Participants in the control group will receive conventional physical therapy following total knee arthroplasty. The rehabilitation program will include early mobilization, pain and swelling management, range of motion exercises, strengthening exercises, gait training, and functional activities such as ankle pumps, heel slides, quadriceps sets, straight leg raises, sit-to-stand training, and walking practice. Sessions will be conducted three times per week for 6 weeks under physiotherapist supervision along with a home exercise program.",[19],"Other: Conventional Physical Therapy alone",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Blood Flow Restriction Exercises and Conventional Physical Therapy","Participants in the experimental group will receive progressive blood flow restriction (BFR) exercise combined with conventional physiotherapy following total knee arthroplasty. BFR will be applied using a pneumatic cuff placed proximally on the operated thigh at 20-40% limb occlusion pressure. Low-load therapeutic exercises will be performed under cuff inflation, including quadriceps sets, straight leg raises, heel slides, ankle pumps, sit-to-stand training, gait training, and functional strengthening exercises. Sessions will be conducted three times per week for 6 weeks under physiotherapist supervision in addition to standard postoperative rehabilitation.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Conventional Physical Therapy alone","Participants in the control group will receive conventional physiotherapy following total knee arthroplasty. The rehabilitation program will include early mobilization, pain and swelling management, range of motion exercises, strengthening exercises, gait training, and functional activities such as ankle pumps, heel slides, quadriceps sets, straight leg raises, sit-to-stand training, and walking practice. Sessions will be conducted three times per week for 6 weeks under physiotherapist supervision along with a home exercise program.",[15],[31],{"name":32,"affiliation":5,"role":33},"Shoaib Waqas","STUDY_CHAIR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Umber Nawaz","CONTACT","+92 333 4888279","Umber.nawaz@ubas.edu.pk",{"name":32,"role":37,"phone":41,"phoneExt":25,"email":42},"+92 302 4552109","Shoaib.waqas@ubas.edu.pk",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":25,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Saleem Memorial Trust Hospital","RECRUITING","Lahore","Punjab Province","Pakistan","PK",{"type":52,"coordinates":53},"Point",[54,55],74.35071,31.558,{"lat":55,"lon":54},[58,62],{"name":59,"role":37,"phone":60,"phoneExt":25,"email":61},"Ahmed Shoaib, Mbbs,FRCS","+923030007321","Ahmed.Shoaib@smth.pk",{"name":63,"role":64,"phone":25,"phoneExt":25,"email":25},"Muhammad Noman Zafar, Dpt,MSPT","PRINCIPAL_INVESTIGATOR",{"type":64,"investigatorFullName":36,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Assistant Professor","100643092","effects-of-progressive-restricted-blood-flow-exercises-in-post-total-knee-arthroplasty-100643092",false,"NCT07601906","Effects of Progressive Restricted Blood Flow Exercises in Post Total Knee Arthroplasty","Effects of Progressive Restricted Blood Flow Exercise on Pain, Range of Motion, Swelling, Proprioception and Kinesiophobia on Patients With Total Knee Arthoplasty","TKA PBFR","Inclusion Criteria:\n\n1. Patients of age 50-65 years.\n2. Primary unilateral TKA due to osteoarthritis.\n3. Individuals with mild to moderate postoperative pain (NPRS score 4-7).\n4. Minimum active knee flexion of 30° \\& an extension lag of no more than 15°.\n5. Patients should be medically stable, cognitively able to follow instructions in Urdu or english, and willing to provide written informed consent\n\nExclusion Criteria:\n\n1. History of deep vein thrombosis within the last six months.\n2. Peripheral vascular disease and active infection.\n3. Severe cardiovascular conditions\n4. Neurological disorders affecting lower limb function","ALL","50 Years","65 Years",{"count":79,"type":80},48,"ESTIMATED","INTERVENTIONAL",[83],"NA","Total knee arthroplasty (TKA) is a commonly performed procedure for advanced knee osteoarthritis. Despite successful surgery, many patients experience postoperative impairments including pain, reduced range of motion (ROM), swelling, impaired proprioception, and kinesiophobia, which may delay functional recovery.\n\nConventional physiotherapy is the standard rehabilitation approach following TKA; however, high-load strengthening exercises are often limited in the early postoperative phase due to pain and reduced tolerance.\n\nBlood flow restriction (BFR) exercise is an emerging rehabilitation technique that enables low-load exercise to produce strength adaptations similar to high-intensity training. While evidence supports its effectiveness for improving muscle strength, its effects on other outcomes such as pain, swelling, proprioception, and kinesiophobia are not well established.\n\nThis randomized controlled trial will compare progressive BFR exercise combined with conventional physiotherapy versus conventional physiotherapy alone in patients following unilateral TKA. A total of 48 participants will be randomly allocated to two groups. The intervention will be delivered over 6 weeks with supervised sessions conducted three times per week.\n\nOutcomes will include pain, knee ROM, swelling, proprioception, kinesiophobia, and functional performance. This study aims to determine whether BFR exercise provides additional benefits in postoperative rehabilitation following TKA.",[86],"Total Knee Arthroplasty Recovery",[88,89,90],"Blood Flow Restriction Exercises","Post-Total Knee Arthroplasty","Conventional Physical Therapy","2026-06-05",{"date":93,"type":94},"2026-06-09","ACTUAL",{"date":96,"type":94},"2026-05-25",{"date":98,"type":80},"2026-11-20",{"name":5,"class":6},1]