[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100540912":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":57,"collaborators":26,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":26,"overallStatus":42,"whyStopped":26,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University of Tartu","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","SHAM_COMPARATOR","SHAM procedure is done one hour before cemented hip arthroplasty and comprises of 4 cycles of 5min sham procedure. Everything apart from the pressure in the cuff is similar to the RIPC procedure.",[13],"Other: SHAM",{"label":15,"type":16,"description":17,"interventionNames":18},"Remote Ischemic preconditioning group","ACTIVE_COMPARATOR","RIPC procedure is done one hour before cemented hip arthroplasty and comprises of 4 ischemia (using brachial cuff with suprasystolic blood pressure for 5 min) and reperfusion (5 min) cycles.",[19],"Procedure: Remote Ischemic Preconditioning",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Remote Ischemic Preconditioning","4 cycles of 5 min pressure (produces an ischemia episode in subject's upper limb) with AutoRIC device (Starfish Medical, Canada)",[15],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"SHAM","4 cycles of 5min light pressure (no ischemia produced) with AutoRIC device (Starfish Medical, Canada) to imitate the RIPC procedure",[9],[32,37],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Kaspar Tootsi, PhD","CONTACT","+372 7318282","kaspar.tootsi@kliinikum.ee",{"name":38,"role":34,"phone":26,"phoneExt":26,"email":39},"Kaarel Ernits, MD","kaarel.ernits@kliinikum.ee",[41],{"facility":5,"status":42,"city":43,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Tartu","50406","Estonia","EE",{"type":48,"coordinates":49},"Point",[50,51],26.72509,58.38062,{"lat":51,"lon":50},[54],{"name":55,"role":34,"phone":56,"phoneExt":26,"email":36},"Kaspar Tootsi, MD, PhD","+3727318282",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Kaspar Tootsi","Principal Investigator","100540912","effects-of-remote-ischaemic-preconditioning-in-cemented-hip-arthroplasty-100540912",false,"NCT06323018","Effects of Remote Ischaemic Preconditioning in Cemented Hip Arthroplasty.","Effects of Remote Ischaemic Preconditioning in Cemented Total Hip Arthroplasty: Randomized Controlled Trial","PRINCIPAL","Inclusion Criteria:\n\n* age \\>65 years\n* undergoing total hip cemented hip arthroplasty\n\nExclusion Criteria:\n\n* previously diagnosed peripheral artery disease on both upper limb\n* RIPC is contraindicated","ALL","65 Years","90 Years",{"count":73,"type":74},200,"ESTIMATED","INTERVENTIONAL",[77],"NA","Total joint arthroplasty is one of the best treatment options for end-stage osteoarthritis. Cemented hip arthroplasty is mainly indicated for elderly patients with poor bone quality and multiple comorbidities. Bone cement implantation syndrome is associated with cemented hip arthroplasty and it has been shown to increase cardiovascular and renal complication and brain damage postoperatively. The aim of this project is to elucidate whether remote-ischemic preconditioning (RIPC) has multi-organ protective effect in cemented hip arthroplasty patients.",[80,81,82,83],"Osteoarthritis, Hip","Cardiovascular Diseases","Bone Cement Implantation Syndrome","Kidney Diseases","2024-04-03",{"date":86,"type":87},"2024-04-04","ACTUAL",{"date":89,"type":87},"2024-03-20",{"date":91,"type":74},"2027-03",{"name":5,"class":6},1]