[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504254":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":42,"responsibleParty":60,"collaborators":26,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":26,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":26,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"The First Hospital of Jilin University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"RIC group","ACTIVE_COMPARATOR","Patients are treated with remote ischemic conditioning (RIC).",[13],"Procedure: Remote ischemic conditioning",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham RIC group","PLACEBO_COMPARATOR","Patients are treated with sham remote ischemic conditioning (sham-RIC).",[19],"Procedure: Sham remote ischemic conditioning",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Remote ischemic conditioning","Remote ischemic conditioning (RIC) is induced by 4 cycles of 5 min of upper limb ischemia followed by 5 min reperfusion. Limb ischemia was induced by the inflation of an automated cuff to the pressure rising by 20 mmHg from baseline systolic pressure. RIC will be conducted twice daily for 7 days.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham remote ischemic conditioning","Sham-RIC is performed in the same way as the treatment group except that the blood pressure cuff is inflated to 60 mmHg, which produces mild pressure sensations but has no blocking impact on blood flow.",[15],[32,38],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Yi Yang, MD, PhD","CONTACT","13756661217","0086","doctor_yangyi@163.com",{"name":39,"role":34,"phone":40,"phoneExt":36,"email":41},"Zhen-Ni Guo, MD, PhD","18186872986","zhen1ni2@163.com",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"First Hospital of Jilin University","RECRUITING","Changchun","Jilin","130000","China","CN",{"type":52,"coordinates":53},"Point",[54,55],125.32278,43.88,{"lat":55,"lon":54},[58],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":59},"doctoryangyi@163.com",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Yi Yang","Vice President of First Hospital of Jilin University","100504254","effects-of-remote-ischemic-conditioning-on-blood-pressure-in-older-patients-with-hypertension-100504254",false,"NCT05845905","Effects of Remote Ischemic Conditioning on Blood Pressure in Older Patients With Hypertension","Inclusion Criteria:\n\n* 1\\) Age ≥65 years and ≤85 years, regardless of gender;\n* 2\\) History of essential hypertension and clinical systolic blood pressure ≥ 140 mmHg, regardless of whether they are receiving antihypertensive medication;\n* 3\\) Willing to participate and sign the informed consent.\n\nExclusion Criteria:\n\n* 1\\) Secondary hypertension;\n* 2\\) Clinical blood pressure ≥ 180\u002F110 mmHg or 24-hour mean arterial pressure ≥ 170\u002F100 mmHg;\n* 3\\) Severe organ dysfunction or failure;\n* 4\\) Severe hematologic disorders or significant coagulation abnormalities;\n* 5\\) History of atrial fibrillation or myocardial infarction within 6 months;\n* 6\\) Individuals who had contraindication of remote ischemic conditioning, such as severe soft tissue injury, fracture or vascular injury in the upper limb, acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc;\n* 7\\) Individuals who will or have received anticoagulant therapy with drugs such as dabigatran, rivaroxaban, warfarin, etc;\n* 8\\) Those who are participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to enrollment;\n* 9\\) Other conditions that the researchers think are not suitable for the project.","ALL","65 Years","85 Years",{"count":74,"type":75},158,"ESTIMATED","INTERVENTIONAL",[78],"NA","The purpose of this study is to learn about effects of remote ischemic conditioning on blood pressure in older patients with essential hypertension.",[81],"Essential Hypertension","2024-10-01",{"date":84,"type":85},"2024-10-02","ACTUAL",{"date":87,"type":85},"2023-05-10",{"date":89,"type":75},"2024-12-31",{"name":62,"class":6},1]