[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589888":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":40,"responsibleParty":55,"collaborators":26,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":26,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":26,"enrollmentInfo":67,"targetDuration":26,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":82,"overallStatus":85,"whyStopped":26,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"TsaoTun Psychiatric Center, Department of Health, Taiwan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Controlled","SHAM_COMPARATOR","The sham group will undergo a placebo procedure using the same rTMS parameters but with a figure-of-eight sham coil, following precedents set by studies on cocaine use disorder treatment (Terraneo et al., 2016).",[13],"Device: sham for repetitive Transcranial Magnetic Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"rTMS treatment group","EXPERIMENTAL","rTMS will be administered at a frequency of 15Hz, with each pulse at 100% rMT intensity. Sessions include 60 pulses per train, with a 26-second inter-train pause, across 40 trains, totaling 2400 pulses over a 20-minute session. Schedule: Participants will receive daily rTMS sessions for the first five days, followed by 5 more sessions for the second week, totaling 10 sessions",[19],"Device: repetitive Transcranial Magnetic Stimulation (rTMS)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","repetitive Transcranial Magnetic Stimulation (rTMS)","Targeting: The left dorsolateral prefrontal cortex (DLPFC) will be the target for treatment.\n\nEquipment: rTMS will be delivered using a Magstim super rapid magnetic stimulator with a 70-mm air-cooled figure-eight-shaped coil. Resting Motor Threshold (rMT) Measurement: rMT is determined through visual twitch responses in the contralateral hand, identifying the minimal intensity needed to elicit thumb movement in 50% of trials.\n\nrTMS will be administered at a frequency of 15Hz, with each pulse at 100% rMT intensity. Sessions include 60 pulses per train, with a 26-second inter-train pause, across 40 trains, totaling 2400 pulses over a 20-minute session.",[15],null,{"type":22,"name":28,"description":11,"armGroupLabels":29,"otherNames":26},"sham for repetitive Transcranial Magnetic Stimulation",[9],[31],{"name":32,"affiliation":33,"role":34},"Ching-Hua Julie Lee, MD., MPH","Tsaotun Psychiatric Center, Ministry of Health and Welfare","PRINCIPAL_INVESTIGATOR",[36],{"name":32,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+886921329989","juliechlee77@gmail.com",[41],{"facility":42,"status":26,"city":43,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"TsaoTun Psychiatric Center","Nantou City","Taiwan","TW",{"type":47,"coordinates":48},"Point",[49,50],120.66387,23.91566,{"lat":50,"lon":49},[53],{"name":32,"role":37,"phone":54,"phoneExt":26,"email":39},"+886-49-2550800",{"type":34,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ching-Hua Julie Lee","Attending Psychiatrist","100589888","effects-of-repetitive-transcranial-magnetic-stimulations-in-patients-with-amphetamine-use-disorders-100589888",false,"NCT06960265","Effects of Repetitive Transcranial Magnetic Stimulations in Patients With Amphetamine Use Disorders","A Pilot Study for the Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Amphetamine Use Disorders: Clinical Outcomes, Near InfraRed Spectroscopy, and Biomarkers","Inclusion Criteria:\n\n* Age ≥20 years.\n* Meeting DSM-5 criteria for substance use disorder made by a specialist in addiction psychiatry.\n* Fluency in Chinese.\n* Willingness and ability to comply with study requirements.\n* Good physical health determined by complete physical examination, and laboratory tests.\n* Patient or a reliable caregiver can be expected to ensure acceptable compliance and visit attendance for the duration of the study.\n* Trained psychiatrists will assess eligible patients using the structured clinical interview for the Mini-International Neuropsychiatric Interview (MINI) (Sheehan et al., 1998) to determine the presence of any psychotic disorder.\n\nExclusion Criteria:\n\n* Evidence of an uncontrolled and\u002For clinically significant medical condition, e.g., cardiac, hepatic and renal failure that would compromise patient safety or preclude study participation.\n* Premorbid mental retardation.\n* Other major Axis-I Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) diagnoses other than substance use disorder.\n* Pregnancy or nursing.\n* History of seizures or epilepsy.\n* History of neurological diseases or traumatic brain injury.\n* Suicidal attempts or risks during screening or study period.\n* Presence of prosthesis devices, e.g. pace-makers, cochlear prosthesis, neuro- stimulators, magnetic cochlear prosthesis, intraocular metallic fragments.","ALL","20 Years",{"count":68,"type":69},20,"ESTIMATED","INTERVENTIONAL",[72],"NA","Amphetamine Use Disorder (AUD) is a major public health issue in Taiwan, where it is the most commonly abused illegal drug. There are currently no effective approved medications to treat it, which makes finding new treatment options urgent. Repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive brain stimulation method, has shown promise in reducing cravings and drug use in people with addiction, but its effects on AUD are not well studied.\n\nTo explore this, the investigators plan to conduct a double-blind, sham-controlled study with 20 people diagnosed with AUD. Half will receive real rTMS treatment, and half will receive a placebo-like sham treatment. The treatment targets a specific brain area (the left dorsolateral prefrontal cortex) and will be given 10 times over two weeks.\n\nThe investigators will assess the effectiveness of rTMS by tracking drug cravings, urine test results, and side effects with follow-up over 12 weeks. The investigators also include brain imaging using near-infrared spectroscopy (NIRS) after the treatment.\n\nThe study aims to better understand how rTMS might help reduce amphetamine cravings and improve outcomes, potentially leading to new treatment options for AUD.",[75,76,77,78,79,80,81],"Amphetamine Use Disorders","Amphetamine Use Disorder","Amphetamine Dependence","Amphetamine Abuse","NIRS","rTMS","rTMS Stimulation",[83,84,79],"amphetamine","rtms","NOT_YET_RECRUITING","2025-04-28",{"date":88,"type":89},"2025-05-07","ACTUAL",{"date":91,"type":69},"2025-05-15",{"date":93,"type":69},"2025-12-31",{"name":5,"class":6},1]