[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604644":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":25,"locations":31,"responsibleParty":56,"collaborators":24,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":24,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":34,"whyStopped":24,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Universidad de La Frontera","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Charcot Marie Tooth (CMT Group)","EXPERIMENTAL","Participants with Charcot-Marie-Tooth (CMT) will perform an 8-week supervised lower limb Progressive Resistance Exercise Training (RET) program, 3 times per week. Assessments will be conducted pre- and post-intervention to evaluate muscle quality, functional capacity, and quality of life.",[13],"Other: Progressive Resistance Exercise Training",{"label":15,"type":16,"description":17,"interventionNames":18},"CONTROL Group","ACTIVE_COMPARATOR","Healthy participants (without Charcot Marie Tooth) will perform an 8-week supervised lower limb Progressive Resistance Exercise Training (RET) program, 3 times per week. Assessments will be conducted pre- and post-intervention to evaluate muscle quality, functional capacity, and quality of life.",[13],[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Progressive Resistance Exercise Training","Progressive Resistance Exercise Training Supervised (RET) focusing on lower limbs. Warm-up (5 min cycling), followed by 5 sets of leg press, leg extension, leg curl, and weighted dorsiflexion. Cool-down with flexibility exercises. Load progression from 60% to 80% of 1Repetition Maximum across 8 weeks. Participants must complete ≥80% of sessions. Evaluators of pre- and post-intervention outcomes will be blinded.",[15,9],null,[26],{"name":27,"role":28,"phone":29,"phoneExt":24,"email":30},"Fernando J Valenzuela, MSc","CONTACT","+56950166328","fernando.valenzuela@ufrontera.cl",[32,51],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Temuco, Chile","RECRUITING","Temuco","La Araucanía","4812790","Chile","CL",{"type":41,"coordinates":42},"Point",[43,44],-72.59738,-38.73628,{"lat":44,"lon":43},[47],{"name":48,"role":28,"phone":49,"phoneExt":24,"email":50},"FERNANDO EXEQUIEL VALENZUELA NAVARRO","950166328","f.valenzuelaaedo@gmail.com",{"facility":5,"status":52,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":53,"geoPoint":55,"contacts":24},"ACTIVE_NOT_RECRUITING",{"type":41,"coordinates":54},[43,44],{"lat":44,"lon":43},{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Fernando Javier Valenzuela Aedo","Clinical Professor","100604644","effects-of-resistance-exercises-in-hereditary-sensory-motor-neuropathy-charcot-marie-tooth-disease-100604644",false,"NCT07152197","Effects of Resistance Exercises in Hereditary Sensory-Motor Neuropathy (Charcot-Marie-Tooth Disease)","Effects of a Resistance Exercise Training Program on Skeletal Muscle Quality, Functional Capacity, and Quality of Life in Young Individuals With and Without Hereditary Sensorimotor Polyneuropathy","PNP","Inclusion Criteria:\n\n* Men or women between 15 and 29 years of age with a diagnosis of hereditary sensorimotor polyneuropathy (HSPN) in any of its subtypes, living in the community (for experimental group).\n* Healthy men or women between 15 and 29 years of age living in the community (for control group).\n* Having active ankle movement within a range from plantarflexion to at least 0° of ankle dorsiflexion, allowing for strength training.\n\nExclusion Criteria:\n\n* Osteoarticular or mobility impairments that prevent safe performance of resistance exercise training (e.g., ankle arthrodesis).\n* Use of nutritional supplements that may affect skeletal muscle regulation (leucine, glutamine, casein, whey protein, fatty acids, creatine, among others).\n* Untreated and\u002For uncontrolled chronic diseases or intellectual disability.\n* History of surgery\n* Participation in a resistance exercise training program within the past 6 months.",true,"ALL","15 Years","29 Years",{"count":73,"type":74},22,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this clinical trial is to compare the effects of an 8-week resistance exercise training program on skeletal muscle quality, functional capacity, and quality of life in young individuals aged 15 to 29 years, with and without Hereditary Sensorimotor Polyneuropathy (HSPN).\n\nThe main questions to answer are:\n\nWhat is the effect of an 8-week resistance exercise training program on skeletal muscle quality, functional capacity, and quality of life in young individuals with and without HSPN?\n\nWill the percentage of improvement after the program be greater in participants with HSPN compared to those without, due to greater baseline alterations?\n\nResearchers will compare the resistance exercise training program with baseline conditions to determine its effectiveness in improving skeletal muscle quality, functional capacity, and quality of life.\n\nParticipants will undergo a supervised lower-limb resistance exercise program (3x\u002Fweek) for 8 weeks. The intervention will include progressive loads from 60% to 80% of 1-Repetition Maximum (1RM), with exercises targeting the major lower limb muscle groups. All participants will complete pre- and post-intervention evaluations, including ultrasound assessment of muscle architecture, functional capacity tests, strength measurements, body composition analysis, and quality of life questionnaires.",[80,81],"Polyneuropathy","Charcot Marie Tooth Disease (CMT)",[81,83,84,85],"Resistance Training","Muscle Quality","Quality of Life","2025-09-21",{"date":88,"type":89},"2025-09-23","ACTUAL",{"date":91,"type":89},"2025-09-20",{"date":93,"type":74},"2026-09-20",{"name":5,"class":6},2]