[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100509853":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":41,"locations":47,"responsibleParty":62,"collaborators":64,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":45,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":45,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":49,"whyStopped":45,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"New York State Psychiatric Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High-frequency repetitive transcranial magnetic stimulation (HF-rTMS)","EXPERIMENTAL","Target: Region of right DLPFC with greatest resting-state functional connectivity to dorsal striatum (individualized functional target) Protocol: 10 pulses\u002Fsec, 4s trains, 120% MT, 3000 pulses\u002Fsession",[13],"Device: High-frequency repetitive transcranial magnetic stimulation (active rTMS)",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham repetitive transcranial magnetic stimulation (sham rTMS)","SHAM_COMPARATOR","Target: Region of right DLPFC with greatest resting-state functional connectivity to dorsal striatum (individualized functional target) Protocol: same as HF-rTMS, with sham coil",[19],"Device: Sham repetitive transcranial magnetic stimulation (sham rTMS)",[21,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","High-frequency repetitive transcranial magnetic stimulation (active rTMS)","HF-rTMS is applied with a figure-of-8 coil using the Magstim TMS System. Participants receive one administration of HF-rTMS, delivered to the region of the right dorsolateral prefrontal cortex (DLPFC) with greatest resting-state functional connectivity to the dorsal striatum (individualized per participant). HF-rTMS is delivered at a frequency of 10 Hz for approximately 37 minutes (3000 total pulses).",[9],[27,28,29],"Magstim TMS System active coil","High-frequency rTMS","Repetitive Transcranial Magnetic Stimulation",{"type":22,"name":15,"description":31,"armGroupLabels":32,"otherNames":33},"Sham rTMS is applied with a figure-of-8 sham coil using the Magstim TMS System, which is identical to the active coil, replicates the sounds of HF-rTMS, and is designed to mimic sensations of HF-rTMS. Participants receive one administration of sham rTMS, delivered to the region of the right dorsolateral prefrontal cortex (DLPFC) with greatest resting-state functional connectivity to the dorsal striatum (individualized per participant). Sham rTMS is delivered for approximately 37 minutes (3000 total pulses).",[15],[34,35],"Magstim TMS System sham coil","Sham rTMS",[37],{"name":38,"affiliation":39,"role":40},"Alexandra F Muratore, PhD","New York Sate Psychiatric Institute","PRINCIPAL_INVESTIGATOR",[42],{"name":38,"role":43,"phone":44,"phoneExt":45,"email":46},"CONTACT","646-774-8053",null,"afm2166@cumc.columbia.edu",[48],{"facility":5,"status":49,"city":50,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","New York","10032","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-74.00597,40.71427,{"lat":58,"lon":57},[61],{"name":38,"role":43,"phone":44,"phoneExt":45,"email":46},{"type":40,"investigatorFullName":38,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"Assistant Professor of Clinical Medical Psychology (in Psychiatry)",[65,68,70],{"name":66,"class":67},"National Institute of Mental Health (NIMH)","NIH",{"name":69,"class":6},"National Eating Disorders Association",{"name":71,"class":72},"Global Foundation for Eating Disorders","UNKNOWN","100509853","effects-of-rtms-on-food-choice-in-anorexia-nervosa-100509853",false,"NCT05918835","Effects of rTMS on Food Choice in Anorexia Nervosa","Deciphering the Neural Mechanisms of Restrictive Eating in Anorexia Nervosa Using Repetitive Transcranial Magnetic Stimulation","Inclusion Criteria:\n\n* DSM-5 Diagnosis of Anorexia Nervosa\n* Age 18-30 years\n* Female\n* Right-handed\n* Body Mass Index (BMI) ≥ 16.0\n* Voluntarily admitted to inpatient eating disorders unit at NYSPI\n* Competent to provide informed consent\n* English-speaking\n* Medically stable\n\nExclusion Criteria:\n\n* High risk of suicide\n* Current substance use disorder or other co- morbid psychiatric condition requiring specialized treatment (e.g., psychosis)\n* Diagnosis of major medical or neurological problem or taking medication that significantly increases risk for seizure or affects interpretation of findings (e.g., unstable hypertension, seizure disorder)\n* Food restrictions (e.g., allergies) which impact greater than 30% of food choice task's choice options\n* Indwelling ferromagnetic metallic object (e.g., pacemaker, pump), non- removable metal jewelry, medicinal patch or recent metallic ink tattoo\n* History of seizure\n* Diagnosis of epilepsy, stroke, multiple sclerosis, traumatic brain injury, Alzheimer's and other neurodegenerative diseases, meningoencephalitis or intracerebral abscess, or parenchymal or leptomeningeal cancers\n* Prior exposure to TMS\n* Pregnancy\n* Currently breast-feeding\n* Significant claustrophobia\n* Implanted devices or stimulators\n* Hearing loss (e.g., currently undergoing treatment with ototoxic medications or those with cochlear implants)","FEMALE","18 Years","35 Years",{"count":84,"type":85},72,"ESTIMATED","INTERVENTIONAL",[88],"NA","This study will examine the impact of high-frequency repetitive transcranial magnetic stimulation on food choice behavior and related neural activity.",[91],"Anorexia Nervosa",[29,91,93,94],"Restrictive Eating","Feeding and Eating Disorders","2026-02-20",{"date":97,"type":98},"2026-02-23","ACTUAL",{"date":100,"type":98},"2023-04-24",{"date":102,"type":85},"2028-06-30",{"name":5,"class":6},1]