[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600993":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":38,"locations":44,"responsibleParty":61,"collaborators":65,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":26,"eligibilityCriteria":73,"healthyVolunteers":70,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":91,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Children's Hospital of Chongqing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention group","EXPERIMENTAL","The intervention group received systematic exercise training (the Child-Parent- Trainer exercise program) for 12 weeks (5 days\u002Fweek, 60 minutes\u002Fday).",[13],"Procedure: The Child-Parent- Trainer exercise program",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","ACTIVE_COMPARATOR","The control group received regular physical training courses for 12 weeks (5 days\u002Fweek, 60 minutes\u002Fday).",[19],"Procedure: The regular physical training",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","The Child-Parent- Trainer exercise program","The Child-Parent-Trainer exercise program is a 12-week exercise training program, which is based on the sensory and cognitive needs of children with ASD, multiple game forms are integrated to form a multi-sensory intervention model. The exercise program is developed according to the types of exercise recommended in the Exercise Guidelines for Preschool Children of China, including the development of basic motor skills, such as physical movement, posture control, object control; development of important physical qualities, such as agility, balance, coordination. The training program for different age group consists of physical movement items, object control items and limb coordination items. The exercise intensity is moderate.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"The regular physical training","The regular physical training courses will last for 12 weeks. It is training in motor skills and fine motor skills. The items include passing the ball, lifting small dumbbells, running, handicrafts, etc. There is no requirement for the intensity of the exercise.",[15],[32,35],{"name":33,"affiliation":5,"role":34},"Li Chen, doctor","STUDY_DIRECTOR",{"name":36,"affiliation":5,"role":37},"yu T Li, Doctor","STUDY_CHAIR",[39],{"name":33,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","136 7762 0103","+86","chenli2012@126.com",[45],{"facility":46,"status":26,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Growth, Development and Mental health of Children and Adolescence Center","Chongqing","Chongqing Municipality","400014","China","CN",{"type":53,"coordinates":54},"Point",[55,56],106.55771,29.56026,{"lat":56,"lon":55},[59],{"name":60,"role":40,"phone":41,"phoneExt":42,"email":43},"Li Chen, MD",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Chen Li","Professor, Director",[66],{"name":67,"class":6},"Gansu Provincial Maternal and Child Health Care Hospital","100600993","effects-of-systematic-exercise-training-on-core-symptoms-executive-function-and-brain-function-in-children-with-asd-100600993",false,"NCT07104708","Effects of Systematic Exercise Training on Core Symptoms, Executive Function and Brain Function in Children With ASD","Inclusion Criteria:\n\n* Age: 3-9 years old.\n* Meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria for ASD, And hold a certificate of ASD diagnosis issued by a Tertiary A hospital.\n* Borderline\u002Fnormal intelligence or mild intellectual disability.\n* No serious behavior or emotional problems.\n* Able to simply ask and answer questions.\n* Be able to proactively express the need to use the toilet.\n* There are no physical impairments that affected participation in physical activities, and participants are able to cooperate to complete the intervention.\n* Informed parental consent.\n\nExclusion Criteria:\n\n* Vision\u002F hearing disorders, schizophrenia, emotional disorders, mental retardation, Rett syndrome and other developmental disorders.\n* Medical conditions that limit the ability to be physically active, such as asthma, epilepsy, heart disease, and the acute phase after a fracture.\n* History of head trauma, physical disability, major organ disease, or severe musculoskeletal injury in the past two years.\n* Those who have participated in physical exercise regularly within the last 6 months.\n* Participants who changed treatment intervention midway after inclusion.\n* Unable to cooperate with persistent completion of intervention.","ALL","3 Years","9 Years",{"count":78,"type":79},70,"ESTIMATED","INTERVENTIONAL",[82],"NA","Studies have shown that children with ASD simultaneously have deficits in overall executive function and impairments in basic motor skills, which have a negative impact on cognitive and social all-round development. In recent years, intervention measures for the motor skills of children with ASD have gradually developed. However, based on the existing literature, there is still a lack of recommendations for sports training at present. The sustained effect of exercise intervention training on the core symptoms of ASD remains unclear. In terms of executive function, there are relatively few studies on the executive function of preschool children. The impact of motor training on working memory in school-aged children is still inconsistent. Furthermore, the connection characteristics of different brain regions in children with ASD after physical training remain unclear. This study will include 70 children with ASD aged 3 to 9 years for a multicenter randomized controlled trial (RCT). These children will be randomly assigned to the intervention group (Child-Parent-Trainer program) and the control group (regular physical education program) for 12 weeks, 5 days\u002Fweek, 60 minutes\u002Fday training. Children's core symptoms, executive function, child\u002Ffamily quality of life, and functional near-infrared spectroscopy (fNIRS) were assessed at baseline (training weeks 0) and endpoints (training weeks 13 and 17), respectively. To verify the improvement effect of this exercise program on the autism severity, core symptoms and executive functions of children with ASD, as well as its impact on family quality of life. Furthermore, through fNIRS for monitoring changes in brain function, the potential neural physiological mechanisms will be explored.",[85],"Autism Spectrum Disorder",[87,88,89,90],"executive function","brain function","exercise training","Autism spectrum disorder","NOT_YET_RECRUITING","2025-08-09",{"date":94,"type":95},"2025-08-14","ACTUAL",{"date":97,"type":79},"2025-08",{"date":99,"type":79},"2028-06",{"name":63,"class":6},1]