[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545023":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":35,"responsibleParty":50,"collaborators":25,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":25,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":25,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":25,"overallStatus":37,"whyStopped":25,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"The Hong Kong Polytechnic University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active-tDCS","EXPERIMENTAL","For active-tDCS condition, participants will receive stimulation on the dorsolateral prefrontal cortex with ramp up and ramp down mode for 10 seconds, eliciting a tingling sensation on the scalp that fades over seconds.",[13],"Device: tDCS with cognitive training programme",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham-tDCS","SHAM_COMPARATOR","For sham-tDCS condition, participants will receive initial stimulation with ramp up and ramp down mode for 30 seconds, eliciting a tingling sensation on the scalp then it will be discontinued.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","tDCS with cognitive training programme","Participants will complete tDCS over 10 sessions in 2 weeks (once per day, for 10 consecutive working days), while performing the executive function training tasks. The training session will last for 20 minutes and it is comprised of 5 exercises targeting at information processing speed and executive function capacities. Each exercise lasts for approximately 4 minutes, totaling approximately 20 minutes.",[9,15],null,[27],{"name":28,"affiliation":5,"role":29},"Yvonne Han, PhD","PRINCIPAL_INVESTIGATOR",[31],{"name":28,"role":32,"phone":33,"phoneExt":25,"email":34},"CONTACT","+852 2766 7578","yvonne.han@polyu.edu.hk",[36],{"facility":5,"status":37,"city":38,"state":39,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Hung Hom","Kowloon","Hong Kong","HK",{"type":43,"coordinates":44},"Point",[45,46],114.18532,22.30715,{"lat":46,"lon":45},[49],{"name":28,"role":32,"phone":33,"phoneExt":25,"email":25},{"type":29,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Dr Yvonne Han","Associate Professor","100545023","effects-of-tdcs-for-enhancing-cognitive-function-in-individuals-with-persistent-post-concussion-syndrome-100545023",false,"NCT06376500","Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome","Effects of Transcranial Direct Current Stimulation for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome: A Pilot fMRI\u002F1H-MRS Study","Inclusion Criteria:\n\n* being 18 years old or older;\n* having a history of a mild TBI (less than 30 minutes loss of consciousness) 1-6 years prior to the study;\n* able to communicate in Chinese.\n\nExclusion Criteria:\n\n* being without a confirmed diagnosis from the medical practitioner;\n* having a history of other neurological and psychiatric disorders, skull defect, recent medical instability (within 3 weeks);\n* being pregnant;\n* being medication for a psychiatric condition (e.g., major depression, anxiety, schizophrenia);\n* with any implanted devices or suffering from real claustrophobia or feel uncomfortable in small, enclosed spaces, like MRI tunnel","ALL","18 Years","65 Years",{"count":64,"type":65},40,"ESTIMATED","INTERVENTIONAL",[68],"NA","Globally, 10 million new traumatic brain injury (TBI) cases are estimated annually, with mild traumatic brain injury (mTBI) accounting for 75-90% of all TBI cases. It is estimated that 40-80% of individuals with mTBI may experience the post-concussion syndrome (PCS), which is characterized by a range of physical, cognitive, and emotional symptoms. Although the underlying basis of cognitive dysfunction of patients with persistent PCS remains to be clarified, converging evidence shows that the clinical symptoms is underpinned by abnormal neural information processing as a result of axonal injury due to mTBI. Recent studies have demonstrated abnormalities in both structural and functional cortical connectivity, and a loss of cortical excitability-inhibitory (E\u002FI) balance after TBI. Yet, there is no consensus for treating chronic symptoms of concussion, and PCS remains a chronic and highly disabling condition. One potential treatment option is transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique that has been shown to modify behavior by enhancing connectivity between targeted brain areas. However, research on the therapeutic effect of tDCS on PCS symptoms is limited, and the neurologic mechanisms underlying its effects are not well understood. The proposed study aims to address these knowledge gaps by examining the effects of tDCS on the central nervous system function in patients with PCS, with a specific focus on functional cortical connectivity and cognitive functions such as processing speed and executive function. The study also aims to add value to existing evidence by potentially opening new directions for designing intervention programs for the treatment of PCS after mTBI.",[71,72,73,74],"Transcranial Direct Current Stimulation","Post-Concussion Syndrome","Functional Magnetic Resonance Imaging","Magnetic Resonance Spectroscopy","2025-09-18",{"date":77,"type":78},"2025-09-19","ACTUAL",{"date":80,"type":78},"2025-09-01",{"date":82,"type":65},"2028-02",{"name":5,"class":6},1]